Decreased core-fucosylation contributes to malignancy in gastric cancer. [PDF]
PLoS ONE, 2014 The object of the study is to identify N-glycan profiling changes associated with gastric cancer and explore the impact of core-fucosylation on biological behaviors of human gastric cancer cells.
Yun-Peng Zhao +10 more
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Advances in the study of core fucosylation in mammals
浙江大学学报. 农业与生命科学版, 2021 Glycosylation is a major posttranslational modification, which involves in the regulation of important physiological functions. Among them, core fucosylation is an α1, 6-linked fucose to N-glycans, which catalyzes by only one glycosyltransferase.
TIAN Yinping, YI Wen
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Blocking core fucosylation of epidermal growth factor (EGF) receptor prevents peritoneal fibrosis progression [PDF]
Renal Failure, 2021 Objective Peritoneal fibrosis (PF) ultimately causes ultrafiltration failure and peritoneal dialysis (PD) termination, but there are few effective therapies for it.
Changqing Yu +6 more
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Fut8-Mediated Core Fucosylation of Toll-Like Receptor 4 Exacerbates Periodontitis Via Hyperactivation of NF-κB Signalling [PDF]
International Dental JournalBackground: Chronic inflammation in periodontitis is linked to aberrant glycosylation, yet the molecular mechanisms and therapeutic potential of the core fucosyltransferase Fut8 remain undefined.
Jiahao Lin +8 more
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Core Fucosylation of the T Cell Receptor Is Required for T Cell Activation [PDF]
Frontiers in Immunology, 2018 CD4+ T cell activation promotes the pathogenic process of systemic lupus erythematosus (SLE). T cell receptor (TCR) complex are highly core fucosylated glycoproteins, which play important roles in T cell activation.
Wei Liang +10 more
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EGFR core fucosylation, induced by hepatitis C virus, promotes TRIM40-mediated-RIG-I ubiquitination and suppresses interferon-I antiviral defenses [PDF]
Nature CommunicationsAberrant N-glycosylation has been implicated in viral diseases. Alpha-(1,6)-fucosyltransferase (FUT8) is the sole enzyme responsible for core fucosylation of N-glycans during glycoprotein biosynthesis.
Qiu Pan +6 more
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Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion [PDF]
Advanced ScienceGlycosylation, the covalent attachment of glycans to proteins, lipids, and RNAs, is fundamental in regulating diverse biological processes. Glycosylation patterns are aberrantly altered in the tumor microenvironment and closely associated with tumor ...
Yuting Cao +8 more
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Core fucosylation and its roles in gastrointestinal glycoimmunology. [PDF]
World J Gastrointest Oncol, 2023 Esophageal cancer (EC) is one of the most common digestive system malignancies in the world. The combined modality treatment of EC is usually surgery and radiation therapy, however, its clinical efficacy for advanced patients is relatively limited. Ferroptosis, a new type of iron-dependent programmed cell death, is different from apoptosis, necrosis ...
Zhang NZ +7 more
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FUT8 upregulates CD36 and its core fucosylation to accelerate pericyte-myofibroblast transition through the mitochondrial-dependent apoptosis pathway during AKI-CKD [PDF]
Molecular MedicineBackground Activation of pericytes leads to renal interstitial fibrosis, but the regulatory mechanism of pericytes in the progression from AKI to CKD remains poorly understood. CD36 activation plays a role in the progression of CKD.
Yaxi Shang +9 more
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FUT8 promotes breast cancer cell invasiveness by remodeling TGF-β receptor core fucosylation [PDF]
Breast Cancer Research, 2017 Background Core fucosylation (addition of fucose in α-1,6-linkage to core N-acetylglucosamine of N-glycans) catalyzed by fucosyltransferase 8 (FUT8) is critical for signaling receptors involved in many physiological and pathological processes such as ...
Cheng-Fen Tu +4 more
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