Results 11 to 20 of about 904 (174)

Acute hepatotoxicity of Crotalus durissus terrificus (South American rattlesnake) venom in rats

Journal of Venomous Animals and Toxins Including Tropical Diseases, 2009
Venom of the South American rattlesnake, Crotalus durissus terrificus (Cdt), presents myotoxic and neurotoxic outcomes, but reports on its effects on the liver are scarce.
Hyslop S
exaly   +3 more sources

Biochemical and biological evaluation of gyroxin isolated from Crotalus durissus terrificus venom

Journal of Venomous Animals and Toxins Including Tropical Diseases, 2011
Gyroxin, a thrombin-like enzyme isolated from Crotalus durissus terrificus venom and capable of converting fibrinogen into fibrin, presents coagulant and neurotoxic activities.
Luciana Barros, Benedito Barraviera, Barraviera B   +2 more
exaly   +3 more sources

Crotalus durissus terrificus venom interferes with morphological, functional, and biochemical changes in murine macrophage. [PDF]

Mediators Inflamm, 2005
Crotalus durissus terrificus venom (Cdt) is toxic for a variety of eukaryotic cells, especially at high concentrations. However its effects on host immune cells are not well known. The purpose of this study was to determine the effect of Cdt on functional status and the mediators production in peritoneal macrophages. The effects of Cdt were analyzed in
Cruz AH, Mendonça RZ, Petricevich VL.
europepmc   +5 more sources

Crotoxin Isolated from Crotalus durissus terrificus Venom Modulates the Functional Activity of Dendritic Cells via Formyl Peptide Receptors. [PDF]

J Immunol Res, 2018
The Crotalus durissus terrificus rattlesnake venom, its main toxin, crotoxin (CTX), and its crotapotin (CA) and phospholipase A2 (CB) subunits modulate the immune system. Formyl peptide receptors (FPRs) and lipoxin A4 (LXA4) are involved in CTX’s effect on macrophages and neutrophils. Dendritic cells (DCs) are plasticity cells involved in the induction
Freitas AP, Favoretto BC, Clissa PB, Sampaio SC, Faquim-Mauro EL.   +4 more
europepmc   +2 more sources

In vivo and in vitro prospection of the anti-ophidic properties exercised by the extracts of Jacaranda decurrens L.

Acta Scientiarum: Biological Sciences, 2021
The research and development of alternative treatments for snakebites (e.g., medicinal plants) is necessary due to the high costs of the existing ones.
Marcus Vinícius Cardoso Trento, Mateus Santos Carapiá, Pedro Henrique Souza César, Mariana Aparecida Braga, Andreimar Martins Soares, Silvana Marcussi   +5 more
doaj   +1 more source

The origin of the diversity of crotoxin isoforms in the venom of Crotalus durissus terrificus [PDF]

European Journal of Biochemistry, 1994
Crotoxin, the main toxin from the venom of the South American rattlesnake Crotalus durissus terrificus, is a β‐neurotoxin which consists of the non‐covalent association of two subunits: a phospholipase A2 subunit B (CB), and a non‐enzymic subunit A (CA).
G, Faure, V, Choumet, C, Bouchier, L, Camoin, J L, Guillaume, B, Monegier, M, Vuilhorgne, C, Bon   +7 more
openaire   +2 more sources

Geographic variation of individual venom profile of Crotalus durissus snakes [PDF]

Journal of Venomous Animals and Toxins including Tropical Diseases, 2020
Background: South American rattlesnakes are represented in Brazil by a single species, Crotalus durissus, which has public health importance due to the severity of its envenomation and to its wide geographical distribution.
Leandro Norberto da Silva-Júnior, Lara de Souza Abreu, Caroline Fabri Bittencourt Rodrigues, Nathália da Costa Galizio, Weslei da Silva Aguiar, Caroline Serino-Silva, Valdomiro Souza dos Santos, Isabella Alves Costa, Luis Vicente Franco Oliveira, Sávio Stefanini Sant’Anna, Kathleen Fernandes Grego, Anita Mitico Tanaka-Azevedo, Leandro Nascimento da Silva Rodrigues, Karen de Morais-Zani   +13 more
doaj   +1 more source

Cell Penetrating Peptides: Classification, Mechanisms, Methods of Study, and Applications

ChemMedChem, Volume 18, Issue 17, September 1, 2023., 2023
Cell penetrating peptides constitute a heterogeneous class of peptides with peculiar features that make them particularly well‐suited for the delivery of almost every type of molecule. Due to their versatility, they are becoming increasingly important in various biomedical applications.
Alessandro Gori, Giulia Lodigiani, Stella G. Colombarolli, Greta Bergamaschi, Alberto Vitali   +4 more
wiley   +1 more source

Anti‐Metalloprotease P‐I Single‐Domain Antibodies: Tools for Next‐Generation Snakebite Antivenoms

BioMed Research International, Volume 2022, Issue 1, 2022., 2022
In order to address the global antivenom crisis, novel antivenoms need to present high therapeutic efficacy, broad neutralization ability against systemic and local damage, sufficient safety, and cost‐effectiveness. Due to biological characteristics of camelid single‐domain antibodies (VHH) such as high affinity, their ability to penetrate dense ...
Marcela C. S. Silva, Soraya S. Pereira, Marilia P. Gouveia, Marcos B. Luiz, Rosa M. O. Sousa, Anderson M. Kayano, Aleff F. Francisco, Nidiane D. R. Prado, Leandro S. M. Dill, Marcos R. M. Fontes, Fernando B. Zanchi, Rodrigo G. Stabeli, Andreimar M. Soares, Juliana P. Zuliani, Carla F. C. Fernandes, Carla F. C. Fernandes   +15 more
wiley   +1 more source

New generation of cell‐penetrating peptides: Functionality and potential clinical application

Journal of Peptide Science, Volume 27, Issue 5, May 2021., 2021
New generation of CPPs achieves high uptake efficiency, cell‐ and tissue‐selective internalization, escape from endosomes, stability against proteases, and low toxicity against healthy cells. Certain members are derived from natural sources, and some of them exhibit innate tumor selectivity.
Siegmund Reissmann, Margarita P. Filatova   +1 more
wiley   +1 more source