Results 31 to 40 of about 35,250 (189)
Geographic variation of individual venom profile of Crotalus durissus snakes [PDF]
Journal of Venomous Animals and Toxins including Tropical Diseases, 2020 Background: South American rattlesnakes are represented in Brazil by a single species, Crotalus durissus, which has public health importance due to the severity of its envenomation and to its wide geographical distribution.
Leandro Norberto da Silva-Júnior +13 more
doaj +1 more source
Cell Penetrating Peptides: Classification, Mechanisms, Methods of Study, and Applications
ChemMedChem, Volume 18, Issue 17, September 1, 2023., 2023 Cell penetrating peptides constitute a heterogeneous class of peptides with peculiar features that make them particularly well‐suited for the delivery of almost every type of molecule. Due to their versatility, they are becoming increasingly important in various biomedical applications.
Alessandro Gori +4 more
wiley +1 more source
Anti‐Metalloprotease P‐I Single‐Domain Antibodies: Tools for Next‐Generation Snakebite Antivenoms
BioMed Research International, Volume 2022, Issue 1, 2022., 2022 In order to address the global antivenom crisis, novel antivenoms need to present high therapeutic efficacy, broad neutralization ability against systemic and local damage, sufficient safety, and cost‐effectiveness. Due to biological characteristics of camelid single‐domain antibodies (VHH) such as high affinity, their ability to penetrate dense ...
Marcela C. S. Silva +15 more
wiley +1 more source
New generation of cell‐penetrating peptides: Functionality and potential clinical application
Journal of Peptide Science, Volume 27, Issue 5, May 2021., 2021 New generation of CPPs achieves high uptake efficiency, cell‐ and tissue‐selective internalization, escape from endosomes, stability against proteases, and low toxicity against healthy cells. Certain members are derived from natural sources, and some of them exhibit innate tumor selectivity.
Siegmund Reissmann +1 more
wiley +1 more source
BioMed Research International, Volume 2021, Issue 1, 2021., 2021 Dengue remains one of the most serious and widespread mosquito‐borne viral infections in human beings, with serious health problems or even death. About 50 to 100 million people are newly infected annually, with almost 2.5 billion people living at risk and resulting in 20,000 deaths.
Muhammad Torequl Islam +16 more
wiley +1 more source
Envenomations by Bothrops and Crotalus snakes induce the release of mitochondrial alarmins. [PDF]
PLoS Neglected Tropical Diseases, 2012 Skeletal muscle necrosis is a common manifestation of viperid snakebite envenomations. Venoms from snakes of the genus Bothrops, such as that of B. asper, induce muscle tissue damage at the site of venom injection, provoking severe local pathology which ...
Irene Zornetta +5 more
doaj +1 more source
Toxins, 2021 Systemic envenomation by Crotalus durissus terrificus (South American rattlesnake) can cause coagulopathy, rabdomyolysis, acute kidney injury, and peripheral neuromuscular blockade, the latter resulting in flaccid paralysis.
Isadora Caruso Fontana Oliveira +7 more
doaj +1 more source
Mediators of Inflammation, 1996 The injection of Crotalus durissus terrificus venom into the foot pad of mice did not induce a significant inflammatory response as evaluated by oedema formation, increased vascular permeability and cell migration. The subcutaneous injection of the venom,
Maria C. C. de Sousa e Silva +2 more
doaj +1 more source
Biomolecules, 2020 Respiratory compromise in Crotalus durissus terrificus (C.d.t.) snakebite is an important pathological condition. Considering that crotoxin (CTX), a phospholipase A2 from C.d.t. venom, is the main component of the venom, the present work investigated the
Marco Aurelio Sartim +11 more
doaj +1 more source
Fast venomic analysis of Crotalus durissus terrificus from northeastern Argentina
Toxicon: X, 2020 The complete knowledge of the toxins that make up venoms is the base for the treatment of snake accidents victims and the selection of specimens for the preparation of venom pools for antivenom production. In this work, we used a fast and direct venomics approach to identify the toxin families in the C.d.
Fusco, Luciano S. +6 more
openaire +5 more sources