Frontiers in Immunology, 2023 BackgroundCuproptosis, the most recently identified and regulated cell death, depends on copper ions in vivo. Copper regulates the pathogenesis of Idiopathic pulmonary fibrosis (IPF), but the mechanism of action underlying cuproptosis in IPF remains ...
Chuanqing Jing +6 more
doaj +1 more source
Screening and validating genes associated with cuproptosis in systemic lupus erythematosus by expression profiling combined with machine learning [PDF]
Cell death has long been a focal point in life sciences research, and recently, scientists have discovered a novel form of cell death induced by copper, termed cuproptosis.
Cheng, Ruoying +4 more
core +2 more sources
A novel cuproptosis-related lncRNAs signature predicts prognostic and immune of bladder urothelial carcinoma [PDF]
, 2023 Bladder Urothelial Carcinoma (BLCA) remains the most common urinary system tumor, and its prognosis is poor. Cuproptosis is a recently discovered novel cell death involved in the development of tumor cells.
Jing Dai +3 more
core +1 more source
Role of cuproptosis-related gene in lung adenocarcinoma
Frontiers in Oncology, 2022 BackgroundsLung adenocarcinoma (LUAD) is the most common subtype of lung cancer, which is the leading cause of cancer death. Dysregulation of cell proliferation and death plays a crucial role in the development of LUAD.
Yuan Liu +6 more
doaj +1 more source
Mitochondria-Targeted Multifunctional Nanoparticles Combine Cuproptosis and Programmed Cell Death-1 Downregulation for Cancer Immunotherapy [PDF]
The combination of cuproptosis and immune checkpoint inhibition has shown promise in treating malignant tumors. However, it remains a challenge to deliver copper ions and immune checkpoint inhibitors efficiently and simultaneously to tumors.
Li, Youyou +3 more
core +1 more source
Advanced Science, EarlyView.Copper‐paeonol nanozymes target tumor‐specific reactive oxygen species generation and disrupt fascin‐mediated actin bundling, effectively suppressing tumor growth and metastatic colonization. Abstract Fascin, an actin‐bundling protein universally upregulated in metastatic tumors, drives tumor migration and invasion by promoting filopodia and ...
Peiying Zhang +8 more
wiley +1 more source
Cancer Reports, 2023 Background Cuproptosis has been studied in various aspects as a new form of cell death. Aims We hope to explore the molecular patterns and genes related to cuproptosis in evaluating and predicting the prognosis of hepatocellular carcinoma (HCC), as well ...
Shanbao Li +9 more
doaj +1 more source
A novel cuproptosis-related prognostic signature and potential value in HCC immunotherapy
Frontiers in Molecular Biosciences, 2022 Background: Copper metabolism plays an important role in the tumor microenvironment, and cuproptosis is the last discovered programmed cell death process.
Xiang-Xu Wang +8 more
doaj +1 more source
Tumor cuproptosis and immune infiltration improve survival of patients with hepatocellular carcinoma with a high expression of ferredoxin 1 [PDF]
, 2023 BackgroundCuproptosis is a novel cell death pathway dependent on cellular copper ions and ferredoxin 1 (FDX1). Hepatocellular carcinoma (HCC) is derived from healthy liver as a central organ for copper metabolism.
Heng Xu +5 more
core +1 more source
Immunogenic cuproptosis in cancer immunotherapy via an in situ cuproptosis-inducing system
BiomaterialsCell death-based therapies combined with immunotherapy have great potential in cancer therapy. To further explore and apply the combined therapies, the immunogenicity of different cell death modes in colorectal cancer (CRC) was evaluated by a cause-and-effect framework encompassing 12 cell death modes. Results show robust correlations among cuproptosis,
Jiehan Li +11 more
openaire +2 more sources