Results 51 to 60 of about 7,727 (171)

Biomimetic Copper‐Doped Nano‐Aluminum Adjuvant Potentiates Therapy in Chemoresistant Acute Myeloid Leukemia

Advanced Healthcare Materials, EarlyView.
We developed a novel copper‐doped aluminum nano‐adjuvant (CuNA) to overcome cytarabine resistance in acute myeloid leukemia (AML). CuNA effectively sensitizes drug‐resistant AML cells to cytarabine by inducing mitochondrial dysfunction and inhibiting HMGCR/GPX4 to amplify ferroptosis.
Chao He, Lingxiao Zhang, Yue Xiong, Yu Wang, Yuqing Zeng, Dandan Su, Ran Wang, Ying Li, Hongbo Chen, Fang Cheng, Zhi Ping Xu   +10 more
wiley   +1 more source

Role of cuproptosis-related gene in lung adenocarcinoma

Frontiers in Oncology, 2022
BackgroundsLung adenocarcinoma (LUAD) is the most common subtype of lung cancer, which is the leading cause of cancer death. Dysregulation of cell proliferation and death plays a crucial role in the development of LUAD.
Yuan Liu, Wei Lin, Ying Yang, JingJing Shao, Hongyu Zhao, Gaoren Wang, Aiguo Shen   +6 more
doaj   +1 more source

Identification and immunological characterization of cuproptosis-related molecular clusters in Alzheimer's disease [PDF]

, 2022
IntroductionAlzheimer's disease is the most common dementia with clinical and pathological heterogeneity. Cuproptosis is a recently reported form of cell death, which appears to result in the progression of various diseases. Therefore, our study aimed to
Chunjin Lin, Chunjin Lin, Fan Lin, Fan Lin, Lijuan Wu, Lijuan Wu, Xing Lin, Xing Lin, Yinan Zhao, Yinan Zhao, Yongxing Lai, Yongxing Lai   +11 more
core   +1 more source

Nanotherapies for Atherosclerosis: Targeting, Catalysis, and Energy Transduction

Advanced Healthcare Materials, EarlyView.
Atherosclerosis management is hindered by poor drug targeting and plaque heterogeneity. Nanotechnology overcomes these barriers via three core strategies: (1) target‐engineered nanocarriers that achieve lesion‐specific precision via ligand modification, biomimetic camouflage, stimuli‐responsive release, and self‐propelling nanomotors; (2) catalytic ...
Yuqi Yang, Jingguo Qu, Tonghuan Xiao, Xinyang Han, Michael Tin‐Cheung Ying   +4 more
wiley   +1 more source

Comprehensive analysis of cuproptosis-related genes and tumor microenvironment infiltration characterization in breast cancer

Frontiers in Immunology, 2022
BackgroundCuproptosis is a newly discovered programmed cell death dependent on overload copper-induced mitochondrial respiration dysregulation. The positive response to immunotherapy, one of the most important treatments for invasive breast cancer ...
Shaoran Song, Shaoran Song, Miao Zhang, Miao Zhang, Peiling Xie, Shuhong Wang, Yaochun Wang, Yaochun Wang   +7 more
doaj   +1 more source

Emerging role of immunogenic cell death in cancer immunotherapy. [PDF]

Cancer immunotherapy, such as immune checkpoint blockade (ICB), has emerged as a groundbreaking approach for effective cancer treatment. Despite its considerable potential, clinical studies have indicated that the current response rate to cancer ...
Arimoto, Kei-Ichiro, Liu, Mengdan, Miyauchi, Sayuri, Zhang, Dong-Er   +3 more
core   +1 more source

Cuproptosis and Disulfidptosis Converge to Empower PD‐L1 Checkpoint Therapy via Cadict‐Induced PD‐L1 Translation

Advanced Science, EarlyView.
This study introduces Cadict, an EGFR‐targeted nanodrug that co‐delivers cuproptosis and disulfidptosis inducers to overcome immune resistance. Cadict synergistically enhances tumor cytotoxicity and sensitizes cancers to ICIs by upregulating PD‐L1 via an Eif5b‐dependent translation mechanism, fostering a potent antitumor immune response and ...
Shaoqing Huang, Shiyao Song, Xinhua Zhang, Jialing Gao, Ruihan Pu, Jiatong Dai, Xiaoxue Wu, Lulu Chen, Qinghai Li, Xiaoting Liu, Qi Zhou, Mei Song, Weiling He   +12 more
wiley   +1 more source

Ultra-efficient label-free cell death detection based on multifunctional colorimetric fluorescent in-situ silver nanocluster/graphene nanohybridzyme and its application in environmental biological samples and cellular imaging [PDF]

AgNCs/graphene NHZs) was designed and employed for dual-modal naked-eye colorimetric and fluorometric detection of cell death biomarkers involved in ferroptosis, cuproptosis, and apoptosis.
Agheli, Arash, Gholami, Reza, Hajipour-Verdom, Behnam, Kefayat, Amirhosein, Mahdavian, Reza, Mohseni, Nasim, Molaabasi, Fatemeh, Moosavi-Movahedi, Ali Akbar, Naderi-Manesh, Hossein, Roshanfekr, Afsaneh, Sarrami‐Forooshani, Ramin, Shamsipur, Mojtaba, Yousefi, Vahid   +12 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source

Cuproptosis‐related molecular patterns and gene (ATP7A) in hepatocellular carcinoma and their relationships with tumor immune microenvironment and clinical features

Cancer Reports, 2023
Background Cuproptosis has been studied in various aspects as a new form of cell death. Aims We hope to explore the molecular patterns and genes related to cuproptosis in evaluating and predicting the prognosis of hepatocellular carcinoma (HCC), as well ...
Shanbao Li, Junyong Weng, Chao Xiao, Jing Lu, Wanyue Cao, Fangbin Song, Zeping He, Peng Zhang, Zhonglin Zhu, Junming Xu   +9 more
doaj   +1 more source