Results 61 to 70 of about 7,425 (214)

Ferroptosis‐Mediated Hippocampal Neuronal Loss Post‐mTBI: Chromatin Accessibility Profiling and Single‐Nucleus Transcriptomics

Advanced Science, EarlyView.
Hippocampal single ‐nucleus transcriptomes and chromatin accessibility after mild traumatic brain injury reveal dentate granule neuron vulnerability driven by ferroptosis. The c‐Jun–Tmsb4x–Slc2a2 axis modulates lipid peroxidation and iron dysregulation.
Manrui Li, Qiuyun Yang, Shengqiu Qu, Yang Chen, Yang Shen, Yang Xu, Xilong Lin, Yihan Sun, Ying Chen, Meili Lv, Lin Zhang, Zengqiang Yuan, Weibo Liang, Xiameng Chen   +13 more
wiley   +1 more source

Comprehensive analysis of cuproptosis-related genes and tumor microenvironment infiltration characterization in breast cancer

Frontiers in Immunology, 2022
BackgroundCuproptosis is a newly discovered programmed cell death dependent on overload copper-induced mitochondrial respiration dysregulation. The positive response to immunotherapy, one of the most important treatments for invasive breast cancer ...
Shaoran Song, Shaoran Song, Miao Zhang, Miao Zhang, Peiling Xie, Shuhong Wang, Yaochun Wang, Yaochun Wang   +7 more
doaj   +1 more source

Emerging role of immunogenic cell death in cancer immunotherapy. [PDF]

Cancer immunotherapy, such as immune checkpoint blockade (ICB), has emerged as a groundbreaking approach for effective cancer treatment. Despite its considerable potential, clinical studies have indicated that the current response rate to cancer ...
Arimoto, Kei-Ichiro, Liu, Mengdan, Miyauchi, Sayuri, Zhang, Dong-Er   +3 more
core   +1 more source

Bimetallic Peroxide Nanocomposites‐Driven Redox Dyshomeostasis to Activate Sequential Cuproptosis and Pyroptosis for Amplified Tumor Immunotherapy

Advanced Science, EarlyView.
Hyaluronic acid‐modified bimetallic peroxide nanocomposites (MgO2‐CuO2@HA) are designed for synergistic tumor therapy. The nanocomposites release Mg2+, H2O2, and Cu2+ in tumor cells, induce cuproptosis via Cu+‐mediated protein aggregation, and activate pyroptosis through caspase‐1/gasdermin D pathways for inducing immunogenic cell death, collectively ...
Guanting He, Haixia Zhu, Peipei Kang, Lili Feng, Chenghao Yu, Yanlin Zhu, Bin Liu, Zhengxiao Guo, Piaoping Yang   +8 more
wiley   +1 more source

Comprehensive analysis of cuproptosis-related genes in immune infiltration and diagnosis in ulcerative colitis

Frontiers in Immunology, 2022
ObjectivesCuproptosis is a recently discovered form of programmed cell death; however, its role in ulcerative colitis (UC) remains a void.MethodsThree gene expression profiles were acquired from the GEO database.
Jinke Huang, Jiaqi Zhang, Fengyun Wang, Beihua Zhang, Xudong Tang   +4 more
doaj   +1 more source

Ultra-efficient label-free cell death detection based on multifunctional colorimetric fluorescent in-situ silver nanocluster/graphene nanohybridzyme and its application in environmental biological samples and cellular imaging [PDF]

AgNCs/graphene NHZs) was designed and employed for dual-modal naked-eye colorimetric and fluorometric detection of cell death biomarkers involved in ferroptosis, cuproptosis, and apoptosis.
Agheli, Arash, Gholami, Reza, Hajipour-Verdom, Behnam, Kefayat, Amirhosein, Mahdavian, Reza, Mohseni, Nasim, Molaabasi, Fatemeh, Moosavi-Movahedi, Ali Akbar, Naderi-Manesh, Hossein, Roshanfekr, Afsaneh, Sarrami‐Forooshani, Ramin, Shamsipur, Mojtaba, Yousefi, Vahid   +12 more
core   +1 more source

A cuproptosis random forest cox score model-based evaluation of prognosis, mutation characterization, immune infiltration, and drug sensitivity in hepatocellular carcinoma [PDF]

, 2023
BackgroundHepatocellular carcinoma is the third most deadly malignant tumor in the world with a poor prognosis. Although immunotherapy represents a promising therapeutic approach for HCC, the overall response rate of HCC patients to immunotherapy is less
Fengyue Zhang, Jinrui Wei, Lichuan Wu, Ruiqi Liu, Yingyi Liu   +4 more
core   +1 more source

ERM Inhibition Confers Ferroptosis Resistance through ROS‐Induced NRF2 Signaling

Advanced Science, EarlyView.
ERM inhibition disrupts ERM‐actin interactions, elevating ROS and triggering KEAP1 degradation, which stabilizes and activates NRF2. Nuclear NRF2 induces cytoprotective genes, notably HMOX1, enhancing redox buffering and suppressing lipid peroxidation to resist erastin‐induced ferroptosis.
Menghao Qiao, Liqun Zhou, Minhua Zhou, Yu Fang, Haiying Mai, Lingbo Cao, Kun Xu, Yuan Sang, Minyi Chen, Jiewei Huang, Peiyi Huang, Zhipeng Yan, Chao Wang, Zhangshuai Dai, Dichun Huang, Ronghan He, Lijuan Pang, Yunmiao Guo, Ting Gang Chew, Junqi Huang   +19 more
wiley   +1 more source

Identification and immunological characterization of cuproptosis-related molecular clusters in Alzheimer's disease [PDF]

, 2022
IntroductionAlzheimer's disease is the most common dementia with clinical and pathological heterogeneity. Cuproptosis is a recently reported form of cell death, which appears to result in the progression of various diseases. Therefore, our study aimed to
Chunjin Lin, Chunjin Lin, Fan Lin, Fan Lin, Lijuan Wu, Lijuan Wu, Xing Lin, Xing Lin, Yinan Zhao, Yinan Zhao, Yongxing Lai, Yongxing Lai   +11 more
core   +1 more source

Targeting Lactate and Lactylation in Cancer Metabolism and Immunotherapy

Advanced Science, EarlyView.
Lactate, once deemed a metabolic waste, emerges as a central regulator of cancer progression. This review elucidates how lactate and its epigenetic derivative, protein lactylation, orchestrate tumor metabolism, immune suppression, and therapeutic resistance.
Jiajing Gong, Yuhang Xie, Zhijie Weng, Yongzhi Wu, Longjiang Li, Bo Li   +5 more
wiley   +1 more source