Results 81 to 90 of about 7,727 (171)

A versatile nano-transformer for efficient localization-specific imaging and synergistic therapy of bladder cancer [PDF]

A stepwise morphologic transformation is highly desirable but rarely reported for promoting drug penetration at tumor sites via reducing transport barriers.
Guo, Chang, James, Tony D., Li, Xindi, Li, Yumin, Liu, Fanqi, Wang, Leyu, Xu, Suying   +6 more
core   +1 more source

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

Stimulus‐Responsive Copper Complex Nanoparticles Induce Cuproptosis for Augmented Cancer Immunotherapy

Advanced Science
Cuproptosis, an emerging form of programmed cell death, has received tremendous attention in cancer therapy. However, the efficacy of cuproptosis remains limited by the poor delivery efficiency of copper ion carriers. Herein, copper complex nanoparticles
Fuzhen Hu, Jia Huang, Tiejun Bing, Wenlong Mou, Duo Li, Hanchen Zhang, Yang Chen, Qionghua Jin, Yingjie Yu, Zhiying Yang   +9 more
doaj   +1 more source

Copper(II), a Peculiar Metal Ion for Complexation with Monensin A Ionophore

Chemistry – A European Journal, EarlyView.
Copper(II) forms three chiral and EPR‐active complexes with monensinate A in methanol. Beside the bis [CuL2] and mono [CuL]+ species, the new dinuclear construct [Cu2L]3+ exhibits an [ML]+‐type and a metal salt‐type copper(II) centers weakly bound to each other through counter ion(s) and thus, being magnetically independent.
Máté Levente Kis, Bálint Hajdu, Tamás Jakusch, Zoltán Kele, Petar Dorkov, Rositsa Kukeva, Ivayla Pantcheva, Béla Gyurcsik   +7 more
wiley   +1 more source

Structural and Biological Insights Into Copper(I) Phosphane Complexes With Boron‐Phenylated Poly(3‐(CF3)Pyrazolyl)‐ and Poly(6‐(CF3)‐2‐pyridyl)‐Borates

Chemistry – A European Journal, EarlyView.
This study reports six new copper(I) complexes with unusual coordination and strong anticancer activity against a panel of human cancer cell lines derived from different solid tumors. The most active compounds outperform cisplatin, even in resistant cells, by inhibiting protein disulfide isomerase and inducing redox stress that triggers non‐apoptotic ...
Vo Quang Huy Phan, Jo’ Del Gobbo, Mukundam Vanga, Deepika V. Karade, Cristina Marzano, Valentina Gandin, Laura Rigon, Carlo Santini, Maura Pellei, H. V. Rasika Dias   +9 more
wiley   +1 more source

Cuproptosis‐Related Genes in Immune Infiltration and Diagnosis in Hepatitis B Virus‐Related Acute Liver Failure

Exploration, EarlyView.
The role of cuproptosis in HBV‐ALF was explored via bioinformatics and liver biopsy tissues. There are some crosstalks among cuproptosis, immune infiltration, and ferroptosis (The figure was created by Bio Render). ABSTRACT Hepatitis B virus (HBV) infection poses a significant challenge to global health, particularly in developing countries such as ...
Jingwen Deng, Tao Zhu, Yueyang Wang, Sitong Zhang, Hong Deng, Guilan Quan, Tingting Peng, Chuanbin Wu, Huiqiang Cai, Chao Lu, Xiaopeng Cai   +10 more
wiley   +1 more source

The molecular mechanism and therapeutic landscape of copper and cuproptosis in cancer

Signal Transduction and Targeted Therapy
Copper, an essential micronutrient, plays significant roles in numerous biological functions. Recent studies have identified imbalances in copper homeostasis across various cancers, along with the emergence of cuproptosis, a novel copper-dependent form ...
Ziyu Guo, Danyao Chen, Lei Yao, Yuming Sun, Daishi Li, Jiayuan Le, Yating Dian, Furong Zeng, Xiang Chen, Guangtong Deng   +9 more
doaj   +1 more source

Metabolic Cell Death in Cancer: Ferroptosis, Cuproptosis, Disulfidptosis, and Beyond [PDF]

Cell death resistance represents a hallmark of cancer. Recent studies have identified metabolic cell death as unique forms of regulated cell death resulting from an imbalance in the cellular metabolism.
Gan, Boyi, Mao, Chao, Wang, Min, Zhuang, Li   +3 more
core   +1 more source

Spojevi bis(amino acidato)bakra(II) u krvnoj plazmi – pregled računalno predviđenih strukturnih svojstva i afiniteta vezanja aminokiselina s Cu2+ radi moguće primjene u farmakološkim istraživanjima [PDF]

Neutral bis(amino acidato)copper(II) [Cu(aa)2] coordination compounds are the physiological species of copper(II) amino acid compounds in blood plasma taking the form of bis(l-histidinato)copper(II) and mixed ternary copper(II)-l-histidine complexes ...
Sabolović, Jasmina
core   +2 more sources

Bacterial Biohybrids With Dual Magnet and Hypoxia Tropism for Ferroptosis Activation in Deep Tumor Regions

Exploration, EarlyView.
This study introduces a bacterial biohybrid (Ec@ZFOY) designed to target deep tumor regions using a combination of magnetic and hypoxia‐driven mechanisms for enhanced therapeutic delivery. By incorporating hypoxia‐targeted Escherichia coli and magnetic nanoparticles loaded with a HIF‐1α inhibitor, the biohybrid activates ferroptosis through reactive ...
Sijie Shao, Huilan Zhuang, Tingjie Bai, Xuemei Zeng, Angelo Homayoun All, Shuangqian Yan   +5 more
wiley   +1 more source