Results 81 to 90 of about 7,425 (214)

Radiotherapy promotes cuproptosis and synergizes with cuproptosis inducers to overcome tumor radioresistance

Cancer Cell
Cuproptosis is a recently identified form of copper-dependent cell death. Here, we reveal that radiotherapy (RT) induces cuproptosis in cancer cells, independent of apoptosis and ferroptosis, and depletes lipoylated proteins and iron-sulfur (Fe-S) cluster proteins-both hallmarks of cuproptosis-in patient tumors.
Guang Lei, Mingchuang Sun, Jun Cheng, Rui Ye, Zhengze Lu, Amber Horbath, David Huo, Shengrong Wu, Anagha Alapati, Sadhna Aggarwal, Zhihao Xu, Chao Mao, Yuelong Yan, Jun Yao, Qidong Li, Xiong Chen, Hyemin Lee, Li Zhuang, Dadi Jiang, Apar Pataer, Jack A. Roth, Nicholas Navin, Albert C. Koong, Mingjian James You, Steven H. Lin, Boyi Gan   +25 more
openaire   +2 more sources

Focus on cuproptosis: Exploring new mechanisms and therapeutic application prospects of cuproptosis regulation

Biomedicine & Pharmacotherapy
Cuproptosis is a novel form of regulated cell death, which plays an important role in the physiological and pathological processes of the human body. Despite the increasing research on cuproptosis-related genes (CRGs) and their correlation with diseases, the pathogenesis of cuproptosis-related diseases remains unclear.
Donglin, Hao, Wei, Luo, Yongmin, Yan, Jing, Zhou   +3 more
openaire   +2 more sources

Novel cuproptosis-related prognostic gene profiles in preeclampsia

BMC Pregnancy and Childbirth, 2023
Abstract Background Preeclampsia (PE) is a pregnancy-specific disorder with complex pathogenesis. Cuproptosis is a novel identified form of programmed cell death, however, the link between cuproptosis and clinical outcomes in PE is still not fully understood.
Xiaotong Tang, Yi Liu, Yuanyuan Zhang
openaire   +3 more sources

Nanomaterials‐mediated glycolysis rewriting to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes cutting‐edge advances in glycolysis‐rewiring nanomedicines, emphasizing their mechanisms in reversing immunosuppression and reinvigorating antitumor immune responses. Challenges in clinical translation and future directions for designing multifunctional metabolic‐immune modulators are also critically discussed ...
Zilin Ma, Songyan Li, Jie Yan, Xuechun Wang, Wen Zhao, Yunxuan Song, Dongdong Liu, Jianwei Jiao, Xiuying Duan, Guiqiang Zhang   +9 more
wiley   +1 more source

Copper in colorectal cancer patients: a systematic review and meta-analysis. [PDF]

Several clinical studies have evaluated the relationship between copper on colorectal cancer (CRC), but the results are contradictory. This study aimed to conduct a systematic review and meta-analysis to investigate copper measured in two biological ...
González-Herrera, Lucas, González-Palacios Torres, Carla, Jiménez-Moleón, José Juan, Lozano-Lorca, Macarena, Marín-Burdallo, Inés, Muñoz-Bravo, Carlos, Olmedo-Requena, Rocío   +6 more
core   +1 more source

Copper(II), a Peculiar Metal Ion for Complexation with Monensin A Ionophore

Chemistry – A European Journal, EarlyView.
Copper(II) forms three chiral and EPR‐active complexes with monensinate A in methanol. Beside the bis [CuL2] and mono [CuL]+ species, the new dinuclear construct [Cu2L]3+ exhibits an [ML]+‐type and a metal salt‐type copper(II) centers weakly bound to each other through counter ion(s) and thus, being magnetically independent.
Máté Levente Kis, Bálint Hajdu, Tamás Jakusch, Zoltán Kele, Petar Dorkov, Rositsa Kukeva, Ivayla Pantcheva, Béla Gyurcsik   +7 more
wiley   +1 more source

Recent Progress in the Development of Metal‐Based Radiosensitizations for Cancer Therapy: A Review

Rare Metals, EarlyView.
ABSTRACT Radiotherapy (RT) remains an indispensable means in cancer treatment; however, its therapeutic efficacy is often limited by tumor radioresistance and side effect of damage to healthy tissue. The advances in nanotechnology have propelled metal radiosensitizers to forefront of precision medicine.
Xiao‐Xia Wu, Ding‐Hu Zhang, Chuan Hu, Yi‐Nan Ding, Kun Chen, Yi Jiang, Jun Luo, Fei Cao, Wei‐Yuan Hao, Bin‐Yan Zhong, Jie Lin, Dong Xu, Jia‐Ping Zheng   +12 more
wiley   +1 more source

Is the voltage-gated sodium channel β3 subunit (SCN3B) a biomarker for glioma? [PDF]

Recent studies suggest a need for reliable biomarkers enhancing prognosis prediction and treatment strategies in cancer. Here, we performed a data analysis bearing on the expression of SCN3B, voltage-gated sodium channel (VGSC) β3 subunit, as a possible ...

core   +2 more sources

Identification of copper death-associated molecular clusters and immunological profiles in rheumatoid arthritis [PDF]

, 2023
Objective: An analysis of the relationship between rheumatoid arthritis (RA) and copper death-related genes (CRG) was explored based on the GEO dataset.
Guo, Wentao, Hu, Jinhua, Li, Xin, Liu, Chaozong, Ng, Liqi, Su, Songchuan, Su, Wenlong, Zhao, Qing, Zhong, Jinghong, Zhou, Yu   +9 more
core  

Cuproptosis-related gene ACAD8 inhibits the metastatic ability of colorectal cancer by inducing cuproptosis

Frontiers in Immunology
BackgroundDistant metastasis of colorectal cancer (CRC) significantly impacts patient prognosis. Cuproptosis is a new form of copper ion-dependent cell death. However, whether cuproptosis-related genes (CRGs) play a role in the metastatic potential of CRC remains unclear.
HuiE Zhuang, Yizhen Chen, Yizhen Chen, Sifu Huang   +3 more
openaire   +3 more sources