Results 21 to 30 of about 4,249 (178)

Critical role of the first transmembrane domain of Cx26 in regulating oligomerization and function

Molecular Biology of the Cell, 2012
To identify motifs involved in oligomerization of the gap junction protein Cx26, we studied individual transmembrane (TM) domains and the full-length protein.
Maripillán, Jaime, Jara, Oscar, Pérez Acle, Tomás, Sáez, Juan C., Beyer, Eric C., Figueroa, Vania, Lagos, Carlos F., Berthoud, Viviana M., Martínez, Agustín D., Acuña, Rodrigo, García, Isaac E., Araya Secchi, Raúl   +11 more
core   +6 more sources

De Novo Gene Transcription of Connexin Mediates Cytoplasmic Fluid Exchange and Flocking Transitions in Physiological and Cancerous Epithelial Systems. [PDF]

Adv Sci (Weinh)
EGF‐induced de novo transcription of connexins Cx26 and Cx31 promotes flocking behavior that fluidizes epithelia and enables coordinated collective migration. Connexin‐driven cytoplasmic exchange mechanistically links growth‐factor signaling to invasive dynamics.
Abdo H, Barzaghi L, Shen Y, Bellini E, Martini E, Magni S, Barozzi S, Orsenigo F, Parazzoli D, Beznoussenko GV, Franco JD, Krautgasser F, Kaivola J, Cinquanta M, Lazzarin A, Sigismund S, Ivaska J, Cerbino R, Scita G.   +18 more
europepmc   +2 more sources

Repression of Connexin26 hemichannel activity protects the barrier function of respiratory airway epithelial cells against LPS-induced alteration [PDF]

Cell Communication and Signaling
In respiratory airway epithelial cells, lipopolysaccharide (LPS) treatment induced an enhancement of connexin 26 (Cx26) hemichannel activity shown by dye uptake experiments after siRNA-mediated knock-down of Cx26.
Tina Lehrich, Anne Dierks, Masina Plenge, Helena Obernolte, Klaudia Grieger, Katherina Sewald, Frederic Rodriguez, Lucie Malet, Peter Braubach, Florence Bedos-Belval, Anaclet Ngezahayo   +10 more
doaj   +2 more sources

Molecular dynamics simulations of the Cx26 hemichannel: Evaluation of structural models with Brownian dynamics [PDF]

Journal of General Physiology, 2011
The recently published crystal structure of the Cx26 gap junction channel provides a unique opportunity for elucidation of the structure of the conductive connexin pore and the molecular determinants of its ion permeation properties (conductance, current–
Thaddeus A. Bargiello, Taekyung Kwon, Andrew L. Harris, Angelo Rossi   +3 more
core   +3 more sources

Aberrant Cx26 Hemichannels and Keratitis-Ichthyosis-Deafness Syndrome: Insights into Syndromic Hearing Loss [PDF]

Frontiers in Cellular Neuroscience, 2014
Mutation of the GJB2 gene, which encodes the connexin Cx26 gap junction (GJ) protein, is the most common cause of hereditary, sensorineural hearing loss.
Helmuth Alberto Sanchez, Vytas K Verselis   +1 more
doaj   +2 more sources

An Ala/Glu difference in E1 of Cx26 and Cx30 contributes to their differential anionic permeabilities / [PDF]

Journal of General Physiology
Two closely related connexins, Cx26 and Cx30, share widespread expression in the cochlear cellular networks. Gap junction channels formed by these connexins have been shown to have different permeability profiles, with Cx30 showing a strongly reduced ...
Kraujalis, Tadas,, Kraujaliene, Lina,, Šnipas, Mindaugas,, Verselis, Vytas K.,   +3 more
core   +4 more sources

Lack of canonical activities of connexins in highly aggressive human prostate cancer cells [PDF]

Biological Research
Connexins (Cxs) have the ability to form channels that allow the exchange of ions/metabolites between adjacent cells (gap junction channels, GJC) or between the intra- and extra-cellular compartments (hemichannels, HC).
Catalina Asencio, Loreto Véliz, Emilia Flores-Faúndez, Lorena Azócar, Carolina E. Echeverría, Verónica Torres-Estay, Viviana Orellana, Catalina Ramírez-Santelices, Paula Sotomayor, Jorge Cancino, Bredford Kerr, Ainoa Fernandez-Olivares, Mauricio A. Retamal, Juan C. Sáez, Alejandro S. Godoy   +14 more
doaj   +2 more sources

Connexin26 Modulates the Radiosensitivity of Cutaneous Squamous Cell Carcinoma by Regulating the Activation of the MAPK/NF-κB Signaling Pathway

Frontiers in Cell and Developmental Biology, 2021
Previous studies have confirmed that the gap junction protein Connexin26 (Cx26) is specifically expressed in human skin tissue. Cx26 can transmit radiation-induced damage signals.
Minqiong Sun, Yuan Li, Jing Qian, Siwei Ding, Mingyu Sun, Mingyu Sun, Bowen Tan, Ye Zhao   +7 more
doaj   +1 more source

Subcellular Localization of Connexin 26 in Cardiomyocytes and in Cardiomyocyte-Derived Extracellular Vesicles

Molecules, 2021
Connexins (Cxs) are a family of membrane-spanning proteins, expressed in vertebrates and named according to their molecular weight. They are involved in tissue homeostasis, and they function by acting at several communication levels.
Alessandra Falleni, Stefania Moscato, Antonietta R. M. Sabbatini, Margherita Bernardeschi, Francesco Bianchi, Antonella Cecchettini, Letizia Mattii   +6 more
doaj   +1 more source

GJB2 Mutations Linked to Hearing Loss Exhibit Differential Trafficking and Functional Defects as Revealed in Cochlear-Relevant Cells

Frontiers in Cell and Developmental Biology, 2020
GJB2 gene (that encodes Cx26) mutations are causal of hearing loss highlighting the importance of Cx26-based channel signaling amongst the supporting cells in the organ of Corti.
Rianne Beach, Julia M. Abitbol, Brian L. Allman, Jessica L. Esseltine, Qing Shao, Dale W. Laird   +5 more
doaj   +1 more source