Results 31 to 40 of about 4,249 (178)

Cytoplasmic localization of connexin 26 suppresses transition of β‐catenin into the nucleus in intestinal‐ and mix‐type gastric cancer

Annals of Gastroenterological Surgery, 2022
Background Connexin is a basic molecule that forms gap junctions and undergoes localization changes to the cytoplasm in association with carcinogenesis. We aimed to investigate and clarify the significance of cytoplasmic Cx26 expression in gastric cancer.
Nobuhiro Nakazawa, Makoto Sohda, Takehiko Yokobori, Navchaa Gombodorj, Akihiko Sano, Makoto Sakai, Tetsunari Oyama, Hiroyuki Kuwano, Ken Shirabe, Hiroshi Saeki   +9 more
doaj   +1 more source

F-Actin Dysplasia Involved in Organ of Corti Deformity in Gjb2 Knockdown Mouse Model

Frontiers in Molecular Neuroscience, 2022
Mutations in the GJB2 gene encoding connexin26 (Cx26) protein are one of the most common causes of hereditary deafness. Previous studies have found that different Cx26-null mouse models have severe hearing loss and deformity of the organ of Corti (OC) as
Xiao-zhou Liu, Yuan Jin, Sen Chen, Kai Xu, Le Xie, Yue Qiu, Xiao-hui Wang, Yu Sun, Yu Sun, Wei-jia Kong, Wei-jia Kong   +10 more
doaj   +1 more source

A deafness mechanism of digenic Cx26 (GJB2) and Cx30 (GJB6) mutations: Reduction of endocochlear potential by impairment of heterogeneous gap junctional function in the cochlear lateral wall

Neurobiology of Disease, 2017
Digenic Connexin26 (Cx26, GJB2) and Cx30 (GJB6) heterozygous mutations are the second most frequent cause of recessive deafness in humans. However, the underlying deafness mechanism remains unclear.
Ling Mei, Jin Chen, Liang Zong, Yan Zhu, Chun Liang, Raleigh O. Jones, Hong-Bo Zhao   +6 more
doaj   +1 more source

ISCs coordinate excitation of IHCs despite absence of Cx26.

, 2023
(a) Schematic of whole cell patch clamp recordings from IHCs. (b) Representative whole cell voltage clamp trace of spontaneous activity from a control (Gjb2fl/fl) IHC.
Calvin J. Kersbergen (16455643), Patrick O. Kanold (3190650), Travis A. Babola (16455646), Dwight E. Bergles (10583489)   +3 more
core   +1 more source

Local Macrophage-Related Immune Response Is Involved in Cochlear Epithelial Damage in Distinct Gjb2-Related Hereditary Deafness Models

Frontiers in Cell and Developmental Biology, 2021
The macrophage-related immune response is an important component of the cochlear response to different exogenous stresses, including noise, ototoxic antibiotics, toxins, or viral infection.
Kai Xu, Sen Chen, Le Xie, Yue Qiu, Xue Bai, Xiao-Zhou Liu, Hui-Min Zhang, Xiao-Hui Wang, Yuan Jin, Yu Sun, Wei-Jia Kong, Wei-Jia Kong   +11 more
doaj   +1 more source

Pathogenetic role of the deafness-related M34T mutation of Cx26 [PDF]

Human Molecular Genetics, 2006
Mutations in the GJB2 gene, which encodes the gap junction protein connexin26 (Cx26), are the major cause of genetic non-syndromic hearing loss. The role of the allelic variant M34T in causing hereditary deafness remains controversial. By combining genetic, clinical, biochemical, electrophysiological and structural modeling studies, we have re-assessed
BICEGO M, BELTRAMELLO M, CARELLA M, PIAZZA V, ZELANTE L, BUKAUSKAS FF, ARSLAN, EDOARDO, CAMA, ELONA, PANTANO S, BRUZZONE R, D'ANDREA P, D'ANDREA P, MAMMANO, FABIO   +12 more
openaire   +6 more sources

Connexin26 hemichannels with a mutation that causes KID syndrome in humans lack sensitivity to CO2

eLife, 2014
Mutations in connexin26 (Cx26) underlie a range of serious human pathologies. Previously we have shown that Cx26 hemichannels are directly opened by CO2 (Meigh et al., 2013).
Louise Meigh, Naveed Hussain, Daniel K Mulkey, Nicholas Dale   +3 more
doaj   +1 more source

The Functional Role of CONNEXIN 26 Mutation in Nonsyndromic Hearing Loss, Demonstrated by Zebrafish Connexin 30.3 Homologue Model

Cells, 2020
Nonsyndromic hearing loss (NSHL) is of great clinical importance, and mutations in the GJB2 gene and the encoded human CONNEXIN 26 (CX26) protein play important roles in the genetic pathogenesis.
Hsuan-An Su, Ting-Wei Lai, Shuan-Yow Li, Tzu-Rong Su, Jiann-Jou Yang, Ching-Chyuan Su   +5 more
doaj   +1 more source

Clinical significance of the expression of connexin26 in colorectal cancer

Journal of Experimental & Clinical Cancer Research, 2010
Background Connexin26 (Cx26) is one of the connexins (Cxs) family members which form gap junction channels. Cx26 is considered to be a tumor suppressor gene.
Nagahara Hisashi, Fukunaga Shinya, Inoue Toru, Noda Eiji, Maeda Kiyoshi, Nomura Shinya, Hirakawa Kosei   +6 more
doaj   +1 more source

Failure Of Hearing Acquisition in Mice With Reduced Expression of Connexin 26 Correlates With the Abnormal Phasing of Apoptosis Relative to Autophagy and Defective ATP-Dependent Ca2+ Signaling in Kölliker’s Organ

Frontiers in Cellular Neuroscience, 2022
Mutations in the GJB2 gene that encodes connexin 26 (Cx26) are the predominant cause of prelingual hereditary deafness, and the most frequently encountered variants cause complete loss of protein function.
Lianhua Sun, Lianhua Sun, Lianhua Sun, Dekun Gao, Dekun Gao, Dekun Gao, Junmin Chen, Junmin Chen, Junmin Chen, Shule Hou, Shule Hou, Shule Hou, Yue Li, Yue Li, Yue Li, Yuyu Huang, Yuyu Huang, Yuyu Huang, Fabio Mammano, Fabio Mammano, Jianyong Chen, Jianyong Chen, Jianyong Chen, Jun Yang, Jun Yang, Jun Yang   +25 more
doaj   +1 more source