Results 51 to 60 of about 4,249 (178)
Molecular Mechanisms Regulating the Epithelial Barrier: Key Roles for Cx26 and ADAM17 during Bacterial Infection. [PDF]
, 2015 PhDThis study investigated how gastrointestinal and skin bacterial infections were affected by differential expression of connexin (Cx) 26 and a disintegrin and metalloprotease (ADAM) 17 in vitro. Cx26 is a component of gap junctions, which facilitate
Simpson, Charlotte Louise
core +4 more sources
Comparative functional characterization of novel non-syndromic GJB2 gene variant p.Gly45Arg and lethal syndromic variant p.Gly45Glu [PDF]
PeerJ, 2016 We characterized a novel GJB2 missense variant, c.133G>A, p.Gly45Arg, and compared it with the only other variant at the same amino acid position of the connexin 26 protein (Cx26) reported to date: c.134G>A, p.Gly45Glu.
Juan Rodriguez-Paris +4 more
doaj +2 more sources
Cell Death and Disease, 2022 Mutations in the GJB2 gene (encoding Connexin26(Cx26)) are the most common cause of hereditary deafness, accounting for about a quarter of all cases. Sensory epithelial damage is considered to be one of the main causes of deafness caused by GJB2 gene ...
Kai Xu +8 more
doaj +1 more source
Design of Cx26-H and Cx26-Wt groups.
, 2014 Note: Cx26-Wt (IVS1+1G>A non-carriers) is shown in blue, Cx26-H (IVS1+1G>A carriers) is shown in red; bilateral arrows show the compared subgroups; ♀ – female, ♂ – male.
Adyum M. Rafailo (588341) +20 more
core +1 more source
BLG-Cre; Cx26fl/fl mice exhibit a dramatic reduction in Cx26.
, 2014 (A) Real-time PCR analysis of wild-type mice revealed that Cx26, Cx32 and Cx30 are upregulated at parturition and lactation. (B, C) Real-time PCR and Western blot analysis of mammary glands from control (open columns) and Cre-treated (solid columns) mice
John F. Bechberger (302031) +4 more
core +1 more source
Spontaneous activity persists in the developing auditory system of Cx26 cKO mice.
, 2023 (a) Schematic of in vivo widefield epi-fluorescent imaging paradigm to visualize prehearing neural activity in the IC. (b) Representative single calcium events in P7 IC from control (Gjb2fl/fl;Snap25-T2A-GCaMP6s, top) and Cx26 cKO (Tecta-Cre;Gjb2fl/fl ...
Calvin J. Kersbergen (16455643) +3 more
core +1 more source
American Journal of Physiology-Cell Physiology, 2013 Mutations in the human gene encoding connexin 26 (Cx26 or GJB2) cause either nonsyndromic deafness or syndromic deafness associated with skin diseases. That distinct clinical disorders can be caused by different mutations within the same gene suggests that different channel activities influence the ear and skin.
Pallavi V, Mhaske +7 more
openaire +3 more sources
Reduced acoustic sensitivity but retained midbrain tonotopic organization in Cx26 cKO mice.
, 2023 (a) In vivo widefield imaging of tone-evoked IC neural activity in unanesthetized mice after hearing onset. (b) Suprathreshold tone-evoked neural calcium transients in IC from P14 control (Gjb2fl/fl;Snap25-T2A-GCaMP6s, left) and P14 Cx26 cKO (Tecta-Cre ...
Calvin J. Kersbergen (16455643) +3 more
core +1 more source
Compartmentalized and signal-selective gap junctional coupling in the hearing cochlea [PDF]
, 2006 Gap junctional intercellular communication (GJIC) plays a major role in cochlear function. Recent evidence suggests that connexin 26 (Cx26) and Cx30 are the major constituent proteins of cochlear gap junction channels, possibly in a unique heteromeric ...
Jagger, DJ, Forge, A
core
Molecular Genetics & Genomic Medicine, 2021 Background Variants in the GJB2 gene encoding the gap junction protein connexin‐26 (Cx26) can cause autosomal recessive nonsyndromic hearing loss or a variety of phenotypically variable autosomal dominant disorders that effect skin and hearing, such as ...
Emma C. Bedoukian +6 more
doaj +1 more source