Results 61 to 70 of about 4,249 (178)

Gene therapy for hereditary deafness: Progress, challenges and translational implications from OTOF to GJB2

Clinical and Translational Discovery, Volume 6, Issue 5, October 2026.
Current Management & Limitations: Traditional auditory devices lack genetic curative potential and yield variable, non‐physiological hearing outcomes. OTOF gene therapy has shown promising clinical outcomes with dual‐AAV therapy. GJB2 gene therapy remains an emerging approach with significant translational challenges. Advances in vector design and cell‐
Jiahui Zhao, Mengzhao Xun, Yu Sun
wiley   +1 more source

Clock Genes Regulate the Circadian Expression of Piezo1, TRPV4, Connexin26, and VNUT in an Ex Vivo Mouse Bladder Mucosa. [PDF]

PLoS ONE, 2017
ClockΔ19/Δ19 mice is an experimental model mouse for nocturia (NOC). Using the bladder mucosa obtained from ClockΔ19/Δ19 mice, we investigated the gene expression rhythms of mechanosensory cation channels such as transient receptor potential cation ...
Tatsuya Ihara, Takahiko Mitsui, Yuki Nakamura, Satoru Kira, Hiroshi Nakagomi, Norifumi Sawada, Yuri Hirayama, Keisuke Shibata, Eiji Shigetomi, Yoichi Shinozaki, Mitsuharu Yoshiyama, Karl-Erik Andersson, Atsuhito Nakao, Masayuki Takeda, Schuichi Koizumi   +14 more
doaj   +1 more source

A Novel Striated Membrane Contact Site in Vestibular Hair Cells

Biology of the Cell, Volume 118, Issue 10, October 2026.
The mammalian vestibular system features type I and II hair cells (HCs) with distinct neurotransmission: type I uses both ribbon synapses and rapid non‐quantal transmission (NQT). We reveal a novel striated membrane contact between type I HCs and calyceal afferents, linked to atypical mitochondria.
Nicolas Brouilly, Nathalie Pujol, Fabrice Richard, Chantal Cazevieille, Jennifer Stone, Ruth Anne Eatock, Rémy Pujol   +6 more
wiley   +1 more source

Extracellular Divalent Cations Regulation of Cx26 and Cx30 Hemichannels [PDF]

Biophysical Journal, 2013
Due to the large size and modest selectivity of the aqueous pore, exacerbated opening of connexin hemichannels leads to loss of electrochemical gradients and of small cytoplasmic metabolites, causing cell death. Control of hemichannel opening is indispensable, and is achieved by extracellular divalent concentrations, which drastically reduces ...
Lopez, William, Liu, Yu, Harris, Andrew L., Contreras, Jorge E.   +3 more
openaire   +1 more source

Circadian‐Related Serotonin/Melatonin Level Modulates Cisplatin Ototoxicity Susceptibility Depended on NOS3–NO Pathway

Journal of Pineal Research, Volume 78, Issue 4, July 2026.
ABSTRACT Hearing impairment is attributed to factors such as age, genetic predisposition, and environmental influences, among which environmental factors are considered modifiable. Among various environmental factors, the role of poor lifestyle habits is particularly critical, yet the specific mechanisms by which they contribute to hearing damage ...
Siyu Qiu, Shiyi Cai, Rong Xie, Chang Liu, Yingzi He   +4 more
wiley   +1 more source

Spontaneous synaptic activation of SGNs persists in the absence of supporting cell Cx26.

, 2023
(a) Schematic of calcium imaging in SGNs in Snap25-T2A-GCaMP6s mice. (b) Temporally pseudocolored 50 s projection of coordinated spontaneous calcium transients in SGNs from isolated prehearing cochlea in control (Gjb2fl/fl;Snap25-T2A-GCaMP6s, top) and ...
Calvin J. Kersbergen (16455643), Patrick O. Kanold (3190650), Travis A. Babola (16455646), Dwight E. Bergles (10583489)   +3 more
core   +1 more source

Mechanisms of Cx43 and Cx26 transport to the plasma membrane and gap junction regeneration [PDF]

Journal of Cell Science, 2005
Previous reports have suggested that Cx26 exhibits unique intracellular transport pathways en route to the cell surface compared with other members of the connexin family. To directly examine and compare nascent and steady-state delivery of Cx43 and Cx26 to the plasma membrane and gap junction biogenesis we expressed fluorescent-protein-tagged Cx43 and
Tamsin, Thomas, Karen, Jordan, Jamie, Simek, Qing, Shao, Chris, Jedeszko, Paul, Walton, Dale W, Laird   +6 more
openaire   +2 more sources

Macrophage‐Fibroblast Crosstalk Shapes Wound Repair Signaling In Vitro

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Intercellular communication between macrophages and fibroblasts is critical for wound healing. Macrophages promoted fibroblast scratch closure through contact‐dependent mechanisms independent of connexins. In contrast, fibroblasts regulated macrophage cytokine secretion via connexin‐43–mediated contact signaling that increased IL10 and paracrine ...
Daniela Enriquez‐Ochoa, Raji R. Nagalla, Yingzi Liu, Christian F. Guerrero‐Juarez, Hamza Atcha, Gordon Chang, Nancy A. Morales, Hannah J. Hooper, Arian D. Cano, Huy Eng Lim, Michael D. Cahalan, Maksim V. Plikus, Wendy F. Liu   +12 more
wiley   +1 more source

Residues Involved in Cx26 Hemichannels Voltage Dependent Gating [PDF]

Biophysical Journal, 2015
The most well-known role of Connexins (Cxs) is to communicate the cytoplasm of two adjacent cells forming a gap junction channel in the apposition zone. On the other hand, Cxs form the so called “hemichannels”, a fully functional voltage-gated non-selective ion channel, which present two gating mechanism called “slow” and “fast” gating.
Pinto, Bernardo I., Baez-Nieto, David, Pupo, Amaury, Martinez, Agustin, Latorre, Ramon, Gonzalez, Carlos   +5 more
openaire   +1 more source

Role des androgenes dans la régulation de l'expression de Cx26 et Cx32 dans l'épididyme [PDF]

, 2016
Les Connexines (Cxs) composent les jonctions lacunaires permettant aux cellules de communiquer. Lors de la différenciation post-natale de l’épididyme, on assiste à une baisse de l’expression de Cx26 et une augmentation de Cx32.
Adam, Cécile, Cyr, Daniel G.
core   +2 more sources