Results 71 to 80 of about 4,249 (178)
Genetic alterations to Cx26 causing palmoplantar keratoderma and hearing loss modify Cx43 channel behavior [PDF]
, 2015 Junctional-mediated intercellular communication in vertebrates is primarily achieved by clusters of connexin proteins which form gap junctions at the plasma membrane.
Shuja, Zunaira
core +1 more source
Neurobiology of Disease, 2010 Dominant mutations in GJB2, the gene encoding the human gap junction protein connexin26 (Cx26), cause hearing loss. We investigated whether dominant Cx26 mutants interact directly with Cx30.
Sabrina W. Yum +2 more
doaj +1 more source
Rational design of new NO and redox sensitivity into connexin26 hemichannels [PDF]
Open Biology, 2015 CO2 directly opens hemichannels of connexin26 (Cx26) by carbamylating K125, thereby allowing salt bridge formation with R104 of the neighbouring subunit in the connexin hexamer.
Louise Meigh +3 more
doaj +1 more source
Advanced Sensor Research, Volume 5, Issue 4, April 2026.Sensorineural hearing loss (SNHL) occurs in 1.5 billion globally, primary driven by damage of cochlear hair cells and spiral ganglion neurons. This review systematically examines current therapeutic strategies for sensorineural hearing loss, including traditional drug and physical therapies as well as emerging stem cell and gene therapies, providing a ...
Ruirui Chen +3 more
wiley +1 more source
Connexin 30 deletion exacerbates cochlear senescence and age-related hearing loss
Frontiers in Cell and Developmental Biology, 2022 Pathogenic mutations in the Gjb2 and Gjb6 genes, encoding connexin 26 (Cx26) and connexin 30 (Cx30), respectively, have been linked to the most frequent monogenic hearing impairment, nonsyndromic hearing loss, and deafness DFNB1.
Fabiola Paciello +10 more
doaj +1 more source
A simple and reliable method for the detection of the 30delG mutation of the CX26 gene
Molecular and Cellular Probes, 2000 Mutations in the CX26 gene (GJB2), encoding the gap-junction protein Connexin-26, have been shown to be the major cause of non-syndromic recessive deafness. Among these mutations, the deletion of a guanine within the stretch of six G between nucleotide positions +30 and +35 of the CX26 cDNA (30delG) accounts for the majority of this kind of deafness ...
Casademont, Isabelle +4 more
openaire +2 more sources
Gating by Voltage and Ca2+ in Human Connexin (cx26) Hemichannels [PDF]
Biophysical Journal, 2010 Opening of connexin hemichannels permits the release of small metabolites, such as ATP and glutamate, which play an important autocrine/paracrine signaling in a variety of cell types. The recently solved crystal structure of the Cx26 gap junction channel allows us to explore in greater detail the relationship between the structure and function of both,
Contreras, Jorge E. +2 more
openaire +1 more source
Noise-induced threshold shift in Cx26 cKO mice.
, 2016 Click ABR thresholds were measured in wild-type (WT, white, N = 7) and Cx26 conditional knockout (Cx26 cKO, gray, N = 8) mice before (baseline) and 1, 3, 7, and 18 days (PED1-18) after exposure to 1 hr of 8–16 kHz octave-band noise at 106 dB SPL.
Dylan K. Chan (3396527) +1 more
core +1 more source
Developmental Neurobiology, Volume 86, Issue 1, January 2026.ABSTRACT The expression patterns of key membrane pumps and ion channels involved in endolymph cycling have been studied in the rodent inner ear and the developing and adult human cochlea. However, little is known about their expression during the development of the human vestibular system.
Edward S. A. van Beelen +4 more
wiley +1 more source
Aging Cell, Volume 25, Issue 1, January 2026.Chronic low‐concentration lead exposure accelerates the development of ARHL. Lead exposure mediates damage to cochlear sensory cells via the mitochondrial protease LONP1, leading to irreversible hearing loss. ABSTRACT Heavy metal ion exposure has become a global public health concern.
Xue Bai +10 more
wiley +1 more source