Results 141 to 150 of about 42,965 (221)

Spatially defined danger zone shapes gastric cancer progression through CCDC80⁺ fibroblast-induced CD8⁺ T cell dysfunction. [PDF]

Apoptosis
Mo S, Wang Y, Xiong R, Ma L, Xu M, Wang L, Gu W.   +6 more
europepmc   +1 more source

Effect of Red Blood Cell Transfusion on Inflammatory and Angiogenic Pathways in Patients With Sickle Cell Disease

American Journal of Hematology, Volume 101, Issue 4, Page 718-727, April 2026.
ABSTRACT Sickle cell disease (SCD) is a chronic inflammatory state, characterized by increased plasma values of inflammatory and angiogenic proteins. Although red blood cell (RBC) transfusion is known to have immunomodulatory effects in other conditions, its potential effects on the inflammatory state in SCD remain largely unknown.
Lydian A. de Ligt, Sanjay R. Thakoerdin, Maud Zwolsman, Gaby Stegemann, Hanke Matlung, Taco W. Kuijpers, Bart J. Biemond, Karin Fijnvandraat, Robin van Bruggen, Erfan Nur   +9 more
wiley   +1 more source

Dual blockade of DPP-4 and CXCL12/CXCR4 axes synergistically protects podocytes in lupus nephritis. [PDF]

Front Pharmacol
Hu HM, Li YC, Zhang YM, Zhu TY, Yong WJ, Gan YH, Liu C, Duan RY, Xu HD, Zhao ZZ, Qi YY.   +10 more
europepmc   +1 more source

Deciphering the Impact of EPHA1‐AS1 Gene Polymorphism on Social Cognition Deficits in Parkinson's Disease

CNS Neuroscience &Therapeutics, Volume 32, Issue 4, April 2026.
Patients with Parkinson's disease showed poorer social cognition overall regardless of gene. There is an interplay between PD, rs2966700, and positive emotion recognition. PD patients carrying the C allele on rs2966700 performed poorer, suspected due to decreased EPHA1‐AS1 activity and increased inflammation.
Yu‐Chen Lin, Chun‐Hsiang Tan, Wei‐Pin Hong, Rwei‐Ling Yu   +3 more
wiley   +1 more source

Peritumoural adipose tissue drives immune evasion in colorectal cancer via adipose-mesenchymal transformation. [PDF]

Nat Cell Biol
Wang JH, Zheng YQ, Qian ZY, Pan YQ, Tian T, Duan XT, Wang RB, Wang LY, Peng JH, Mo HY, Zhang YY, Han Y, Liao K, Li T, Yang W, Shi GJ, Wu J, Liu ZX, Lin JZ, Xu RH, Ju HQ.   +20 more
europepmc   +1 more source

Adventitial Niches, Complement and Inflammation in Pulmonary Vascular Disease: Current Status and Future Directions

Comprehensive Physiology, Volume 16, Issue 2, April 2026.
Local complement production by pulmonary artery adventitial fibroblasts, activated intracellularly by CFD and CFB and extracellularly by GZMK+ CD8 T cells, and its secretion in soluble form and within EVs promotes macrophage and T cell chemotaxis and activation.
Hui Zhang, Ram Raj Prasad, Sushil Kumar, Min Li, Dallas Jones, Cheng‐Jun Hu, Claudia Mickael, Yen‐Rei Yu, Rubin M. Tuder, Kurt R. Stenmark   +9 more
wiley   +1 more source

Integrated multi-omics profiling to dissect the development of second primary lung cancer in laryngeal cancer: An observational study. [PDF]

Medicine (Baltimore)
Xu F, Huang T, Xu Q, Zhang M, Chen S.
europepmc   +1 more source

The Homeobox Genes: Classification, Regulation, Biological Functions, and Diseases

MedComm, Volume 7, Issue 4, April 2026.
Overview of the homeobox gene superfamily and its pathophysiological roles. The homeobox superfamily comprises several major classes, including ANTP, PRD, TALE, LIM, POU, and others. Among these, the HOX clusters (A–D) play critical roles in embryonic development specifically in conferring cellular identity, regulating morphogenesis, and guiding axial ...
Maedeh Dadzadi, Shahin Ramazi, Mona Darvazi, Sepideh Yoosefi, Melika Abbasi, Shirin Farsad   +5 more
wiley   +1 more source

CXCR4-modification enhances CAR-T efficacy by improving tumor tracking and bone marrow homing in B-cell malignancies. [PDF]

Signal Transduct Target Ther
Shu P, Guo F, Qin D, Zou L, Ma Q, Zhang B, Gao G, Chen Y, He X, Jiang M, Liu N, Zhou K, Zhao J, Lei Y, Gao Y, Zhang Y, Zeng Y, Feng M, Li X, Li D, Wang Y.   +20 more
europepmc   +1 more source

Senescence‐Driven IL‐17A Inflammatory Circuit Promotes Epithelial–Mesenchymal Transition (EMT) and Progression in Age‐Related Posterior Subcapsular Cataracts

Aging Cell, Volume 25, Issue 4, April 2026.
Using multi‐region human PSC samples, we identified EMT as a consistent pathological feature. Mechanistically, senescent LECs secrete IL‐17A, a representative SASP factor, which activates NF‐κB signaling. NF‐κB further amplifies SASP production, thereby establishing a senescence–inflammation feedback loop that drives EMT, sustains pathological ...
Yan Ni, Yu Ma, Zewen Ren, Yi Zhu, Liangping Liu, Runping Duan, Lu Qin, Yang Chen, Rong Ju, Yingyan Qin, Mingxing Wu   +10 more
wiley   +1 more source