Results 191 to 200 of about 42,965 (221)

CXCL12-CXCL4 heterodimerization prevents CXCL12-driven breast cancer cell migration

Cellular Signalling, 2020
Despite improvements in cancer early detection and treatment, metastatic breast cancer remains deadly. Current therapeutic approaches have very limited efficacy in patients with triple negative breast cancer. Among the many mechanisms associated that contribute to cancer progression, signaling through the CXCL12-CXCR4 is an essential step in cancer ...
Khanh T.P. Nguyen, Lawrence J. Druhan, Belinda R. Avalos, Li Zhai, Lubica Rauova, Irina V. Nesmelova, Didier Dréau   +6 more
openaire   +2 more sources

CXCL12: Role in neuroinflammation

The International Journal of Biochemistry & Cell Biology, 2012
CXCL12, also known as SDF-1 (stromal cell derived factor-1) is a small protein that belongs to the chemokine family, whose members have a crucial role in directing cell migration. CXCL12 has an essential role in neural and vascular development, hematopoiesis and in immunity. It acts through two receptors, CXCR4 and CXCR7.
Timotijević, Gordana S, Mostarica-Stojković, Marija B, Miljković, Đorđe   +2 more
openaire   +4 more sources

CXCL12 Signaling in the Tumor Microenvironment

2021
Tumor microenvironment (TME) is the local environment of tumor, composed of tumor cells and blood vessels, extracellular matrix (ECM), immune cells, and metabolic and signaling molecules. Chemokines and their receptors play a fundamental role in the crosstalk between tumor cells and TME, regulating tumor-related angiogenesis, specific leukocyte ...
Luigi, Portella, Anna Maria, Bello, Stefania, Scala   +2 more
openaire   +2 more sources

CXCL12 in control of neuroinflammation

Immunologic Research, 2012
Inflammation within the central nervous system (CNS) is strictly controlled and if possible prevented. Such a tight control is necessary due to high sensitivity of nervous tissue to mechanical and biochemical consequences of inflammation. Still, neuroinflammation is a typical feature of a chronic, inflammatory, demyelinating disease multiple sclerosis (
Momčilović, Miljana, Mostarica-Stojković, Marija B, Miljković, Đorđe   +2 more
openaire   +3 more sources

The CXCR4/CXCL12 axis in endometrial cancer

Clinical & Experimental Metastasis, 2009
Chemokines and their receptors seem to act as important regulators of the metastatic cascade. CXCL12 and its receptor CXCR4 were shown to be involved in human cancer progression. There is increasing evidences suggesting that the expression of CXCR4 in human cancers is correlated with poor patient prognosis and that CXCR4 neutralization can prevent ...
GELMINI, STEFANIA, MANGONI, MONICA, CASTIGLIONE, FRANCESCA, Beltrami C, Pieralli A, Andersson KL, FAMBRINI, MASSIMILIANO, TADDEI, GIAN LUIGI, SERIO, MARIO, ORLANDO, CLAUDIO   +9 more
openaire   +3 more sources

The role of CXCL12 in tumor microenvironment

Gene, 2018
The chemokine ligand C-X-C motif chemokine ligand 12 (CXCL12) is a kind of small molecules of cytokines that widely expressed in diversified tissues. Recent evidence suggests that CXCL12 plays an important role in the communication of tumor cells with their surrounding microenvironment.
Wenfang Meng, Shihang Xue, Ye Chen
openaire   +2 more sources

Tumors block pain with CXCL12

Science Signaling, 2017
The chemokine CXCL12 released from early stage pancreatic cancer recruits Schwann cells and suppresses pain signaling.
openaire   +2 more sources