Results 31 to 40 of about 42,965 (221)

CXCR4, CXCL12 and the relative CXCL12-CXCR4 expression as prognostic factors in colon cancer

Tumor Biology, 2015
The CXCL12-CXCR4 axis is proposed to mediate metastasis formation. In this study, we examined CXCL12, CXCR4 and the relative CXCL12-CXCR4 expression as prognostic factors in two cohorts of colon cancer patients. Immunohistochemistry (IHC) and in situ hybridization (ISH) were used to study CXCR4, CXCL12 and relative CXCL12-CXCR4 expression in tissue ...
Luka, Stanisavljević, Jörg, Aßmus, Kristian Eeg, Storli, Sabine Maria, Leh, Olav, Dahl, Mette Pernille, Myklebust   +5 more
openaire   +2 more sources

CXCL12 (SDF-1)/CXCR4 Pathway in Cancer [PDF]

Clinical Cancer Research, 2010
Abstract Chemokines, small proinflammatory chemoattractant cytokines that bind to specific G-protein-coupled seven-span transmembrane receptors, are major regulators of cell trafficking and adhesion. The chemokine CXCL12 [stromal cell-derived factor-1 (SDF-1)] binds primarily to CXC receptor 4 (CXCR4; CD184).
Beverly A, Teicher, Simon P, Fricker
openaire   +2 more sources

NLRP3 Regulated CXCL12 Expression in Acute Neutrophilic Lung Injury

Journal of Inflammation Research, 2020
Yanwen Peng,1 Qiongli Wu,2 Hao Tang,3 Jingrou Chen,1 Qili Wu,1 Xiaofeng Yuan,4 Shiqiu Xiong,5 Yujin Ye,6 Haijin Lv7 1The Biotherapy Center, The Third Affiliated Hospital, Sun Yat-sen University, Guangzhou 510630, People’s Republic of China ...
Peng Y, Wu Q, Tang H, Chen J, Wu Q, Yuan X, Xiong S, Ye Y, Lv H   +8 more
doaj  

Peroxynitrite Exposure of CXCL12 Impairs Monocyte, Lymphocyte and Endothelial Cell Chemotaxis, Lymphocyte Extravasation in vivo and Anti-HIV-1 Activity

Frontiers in Immunology, 2018
CXCL12 is a chemotactic cytokine that attracts many different cell types for homeostasis and during inflammation. Under stress conditions, macrophages and granulocytes produce factors such as peroxynitrite as a consequence of their oxidative response ...
Rik Janssens, Rik Janssens, Daiane Boff, Daiane Boff, Pieter Ruytinx, Anneleen Mortier, Vincent Vanheule, Olav Larsen, Olav Larsen, Viktorija Daugvilaite, Mette M. Rosenkilde, Sam Noppen, Sandra Liekens, Dominique Schols, Ingrid De Meester, Ghislain Opdenakker, Sofie Struyf, Mauro M. Teixeira, Flávio A. Amaral, Paul Proost   +19 more
doaj   +1 more source

Function of chemokine (CXC motif) ligand 12 in periodontal ligament fibroblasts. [PDF]

PLoS ONE, 2014
The periodontal ligament (PDL) is one of the connective tissues located between the tooth and bone. It is characterized by rapid turnover. Periodontal ligament fibroblasts (PDLFs) play major roles in the rapid turnover of the PDL.
Yuichi Yashiro, Yoshiaki Nomura, Mikimoto Kanazashi, Koji Noda, Nobuhiro Hanada, Yoshiki Nakamura   +5 more
doaj   +1 more source

Upregulation of C-X-C motif chemokine 12 in the spinal cord alleviated the symptoms of experimental autoimmune encephalomyelitis in Lewis rats

Frontiers in Neuroscience, 2023
BackgroundC-X-C motif chemokine 12 (CXCL12) is a chemokine that performs many functions. Studies have shown that CXCL12 can aggravate inflammatory symptoms in the central nervous system (CNS). Evidence also indicates that CXCL12 can promote the repair of
Dahe Lin, Dahe Lin, Dahe Lin, Hongjuan Liu, Hongjuan Liu, Honglu Song, Honglu Song, Biyue Chen, Junxia Fu, Mingming Sun, Huanfen Zhou, Wenhao Bai, Shihui Wei, Hongen Li   +13 more
doaj   +1 more source

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

CXCL12 promotes endometrial repair through MSC homing in a mouse model of intrauterine adhesions: Multimechanistic study based on angiogenesis, cell proliferation and Sirt1 upregulation

陆军军医大学学报
Objective To investigate CXCL12 therapeutic potential in endometrial repair post intrauterine adhesion (IUA) surgery. Methods A murine model of IUA was established using mechanical curettage.
SHAO Kangning, WANG Yaqin
doaj   +1 more source

PARP-1 and YY1 are important novel regulators of CXCL12 gene transcription in rat pancreatic beta cells. [PDF]

PLoS ONE, 2013
Despite significant progress, the molecular mechanisms responsible for pancreatic beta cell depletion and development of diabetes remain poorly defined. At present, there is no preventive measure against diabetes. The positive impact of CXCL12 expression
Jelena Marković, Nevena Grdović, Svetlana Dinić, Teodora Karan-Djurašević, Aleksandra Uskoković, Jelena Arambašić, Mirjana Mihailović, Sonja Pavlović, Goran Poznanović, Melita Vidaković   +9 more
doaj   +1 more source

CXCL12, CXCR4 and CXCR7 expression in brain metastases [PDF]

Cancer Biology & Therapy, 2009
Brain metastases occur in about 25% of patients who die of cancer. The most common sources of brain metastases in adults are lung, breast, kidney, colorectal cancer and melanoma. The chemokine/receptor system CXCL12/CXCR4 plays a key role in multiple biological functions; among these, homing of neoplastic cells from the primary site to the target and ...
Salmaggi, Andrea, Maderna, Emanuela, Calatozzolo, Chiara, Gaviani, Paola, Canazza, Alessandra, Milanesi, Ida, Silvani, Antonio, Di Meco, Francesco, Carbone, Antonino, Pollo, Bianca   +9 more
openaire   +4 more sources