Results 51 to 60 of about 76,809 (334)
Homeostatic and Tissue Reparation Defaults in Mice Carrying Selective Genetic Invalidation of CXCL12/Proteoglycan Interactions. [PDF]
, 2012 International audienceBACKGROUND: Interaction with heparan sulfate proteoglycans is supposed to provide chemokines with the capacity to immobilize on cell surface and extracellular matrix for accomplishing both tissue homing and signaling of attracted ...
Arenzana-Seisdedos, Fernando +11 more
core +4 more sources
Clinical and Experimental Hypertension, 2017 Objective: We investigated whether the CXCL12-801G/A polymorphism was associated with preeclampsia (PE) susceptibility in a Chinese Han population. Methods: We examined 912 PE women and 1025 controls for the CXCL12-801G/A polymorphism by polymerase chain
Jine Xu +6 more
doaj +1 more source
CXCL12 is expressed by skeletal muscle cells in tongue oral squamous cell carcinoma
Cancer Medicine, 2023 Background The CXCL12/CXCR4 axis plays a pivotal role in the progression of various malignancies, including oral squamous cell carcinoma (OSCC).
Akira Yorozu +19 more
doaj +1 more source
A guide to chemokines and their receptors [PDF]
, 2018 The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G‐protein coupled heptahelical chemokine receptors.
Braun A +11 more
core +1 more source
CXCL12, CXCR4 and CXCR7 expression in brain metastases [PDF]
Cancer Biology & Therapy, 2009 Brain metastases occur in about 25% of patients who die of cancer. The most common sources of brain metastases in adults are lung, breast, kidney, colorectal cancer and melanoma. The chemokine/receptor system CXCL12/CXCR4 plays a key role in multiple biological functions; among these, homing of neoplastic cells from the primary site to the target and ...
Salmaggi, Andrea +9 more
openaire +4 more sources
Molecular Oncology, EarlyView.A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He +8 more
wiley +1 more source
Neuropsychiatric Disease and Treatment, 2023 Miaomiao Han,1,2 Bo Ma,3 Ruifang She,4 Yan Xing,5 Xiaohong Li1 1Department of Neurology, Jinan Central Hospital, Shandong University, Jinan City, People’s Republic of China; 2Encephalopathy Department, Zibo Hospital of Integrated Traditional Chinese and ...
Han M, Ma B, She R, Xing Y, Li X
doaj
Hyaluronic acid alters vessel behavior in CXCL12-treated HUVECs [PDF]
, 2018 Hyaluronic acid (HA) is a key component of the extracellular matrix known for absorbing water, swelling, and altering solid stress of tumors. HA’s anionic behavior may provide important biochemical effects toward tumor progression as well.
Seibel, Alex J.
core
Targeting platelet-derived CXCL12 impedes arterial thrombosis
Blood, 2022 Abstract The prevention and treatment of arterial thrombosis continue to be clinically challenging, and understanding the relevant molecular mechanisms in detail may facilitate the quest to identify novel targets and therapeutic approaches that improve protection from ischemic and bleeding events.
Julian Leberzammer +20 more
openaire +5 more sources
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source