Results 91 to 100 of about 10,590 (201)

CXCR7 contributes to the aggressive phenotype of cholangiocarcinoma cells [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2019
Development of cholangiocarcinoma (CCA) is dependent on a cross-talk with stromal cells, which release different chemokines including CXCL12, that interacts with two different receptors, CXCR4 and CXCR7. The aim of the present study was to investigate the role of CXCR7 in CCA cells.
Alessandra Gentilini, Alessandra Caligiuri, Chiara Raggi, Krista Rombouts, Massimo Pinzani, Giulia Lori, Margherita Correnti, Pietro Invernizzi, Elisabetta Rovida, Nadia Navari, Sabina Di Matteo, Domenico Alvaro, Jesus M. Banales, Pedro Rodrigues, Carlotta Raschioni, Matteo Donadon, Luca Di Tommaso, Fabio Marra   +17 more
openaire   +7 more sources

The early stages of heart development: insights from chicken embryos [PDF]

, 2016
The heart is the first functioning organ in the developing embryo and the detailed understanding of the molecular and cellular mechanisms involved in its formation provides insights into congenital malformations affecting its function and therefore the ...
Alsan, Arguello, de la Cruz, de La Cruz, de la Cruz, DeHaan, Hatada, Kitajima, Le Lievre, Needham, Plein, Psychoyos, Rosenquist, Schultheiss, Stern, Tam, Vincent, Waldo, Yatskievych, Zhang   +19 more
core   +2 more sources

Applications of Lysosome‐Targeting Receptors (LTRs) in Targeted Protein Degradation

MedComm – Biomaterials and Applications, Volume 4, Issue 4, December 2025.
Targeted protein degradation based on LYTAC technology has recently emerged as a research hotspot in various diseases. The membrane receptors recently utilized in LYTAC design are summarized in this article, with insights into current strategies, challenges, and prospects for LYTAC‐based technologies.
Lijian Shen, Ziyi Liang, Ying Zhang, Jing Wen, Jie Gao   +4 more
wiley   +1 more source

CXC chemokine receptor 7 ameliorates renal fibrosis by inhibiting β-catenin signaling and epithelial-to-mesenchymal transition in tubular epithelial cells

Renal Failure
Renal fibrosis is a common feature of various chronic kidney diseases. However, the underlying mechanism remains poorly understood. The CXC chemokine receptor (CXCR) family plays a role in renal fibrosis; however, the detailed mechanisms have not been ...
Ping Meng, Chunli Liu, Jingchun Li, Ping Fang, Bo Yang, Wei Sun, Yunfang Zhang   +6 more
doaj   +1 more source

The Aging Landscape by scRNAseq of Mesenchymal Lineage Cells in Mouse Bone

Aging Cell, Volume 24, Issue 12, December 2025.
scRNA‐seq analysis reveals age‐related changes in bone mesenchymal cells in male and female mice. Moreover, the comparison of aging and autophagy deficiency in bone mesenchymal cells shows overlap and suggests that age‐related decline in autophagy contributes to skeletal aging.
Melda Onal, Intawat Nookaew, Ana Resende‐Coelho, Olivia Reyes‐Castro, Adriana Marques‐Carvalho, Landon Gatrell, Alongkorn Kurilung, Alicen James, Aaron Warren, Ha‐Neui Kim, Jinhu Xiong, Charles A. O'Brien, Maria Almeida   +12 more
wiley   +1 more source

グリオブラストーマ細胞の増殖に対するヒト間葉系幹細胞の作用機構解明 [PDF]

, 2013
筑波大学University of Tsukuba博士（医学）Doctor of Philosophy in Medical Sciences2012【要旨 ...
106106, 秋本, 恵子
core   +1 more source

CXCL12/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axonterminals [PDF]

, 2017
The neuromuscular junction has retained through evolution the capacity to regenerate after damage, but little is known on the inter-cellular signals involved in its functional recovery from trauma, autoimmune attacks, or neurotoxins.
Aram Megighian, Bagri A, Cesare Montecucco, Chiara M Mazzanti, Egle Radice, Elisa Duregotti, Elisanna Bergamin, Francesca Lessi, Guyon A, Marco La Ferla, Marco Pirazzini, Marcus Thelen, Michela Rigoni, Michele Menicagli, Paolo Aretini, Samuele Negro, Sara Franceschi, Shellard A   +17 more
core   +1 more source

Targeting RAGE with Nanobodies for Molecular Imaging of Cancers and Alzheimer's Disease

Advanced Biology, Volume 9, Issue 10, October 2025.
RAGE‐specific nanobodies were isolated via phage display and characterized by ELISA, cell ELISA, and SPR. In vivo imaging in renal carcinoma and Alzheimer's disease mouse models demonstrated that NbF8, the highest‐affinity clone, selectively targeted RAGE‐overexpressing tumors and brain tissues, highlighting its potential as a molecular imaging agent ...
Guangfeng Liang, Fujing Wang, Wei Xiong, Guangwei Shi, Junling Yuan, Yang Li, Hongyan Zhang, Yanmei Xing, Shan Jin, Kongjun Yang, Zhongliang Dai, Jichao Sun, Zhijie Li, Jianhong Wang   +13 more
wiley   +1 more source

Alteration of CXCR7 expression mediated by TLR4 promotes tumor cell proliferation and migration in human colorectal carcinoma. [PDF]

PLoS ONE, 2011
The link between inflammation and colorectal carcinoma has been acknowledged. However, the impact of bacterial lipopolysaccharide (LPS) binding to Toll-like receptor 4 (TLR4) on chemokine receptors in human colorectal carcinoma cells still remains to be ...
Huanbai Xu, Qiong Wu, Shipeng Dang, Min Jin, Jingwei Xu, Yiji Cheng, Minglin Pan, Yugang Wu, Chunhui Zhang, Yanyun Zhang   +9 more
doaj   +1 more source

The molecular and phenotypic basis of the glioma invasive perivascular niche [PDF]

, 2017
Gliomas are devastating brain cancers that have poor prognostic outcomes for their patients. Short overall patient survival is due to a lack of durable, efficacious treatment options.
Diksin, Mohammed, Rahman, Ruman, Smith, Stuart J.   +2 more
core   +1 more source