Exosomes in Intervertebral Disc Regeneration: Roles, Opportunities, and Challenges
Advanced NanoBiomed Research, Volume 5, Issue 10, October 2025.Factors of Intervertebral Disc Degeneration Extracellular Matrix (ECM) Exosomes and Intervertebral Disc Degeneration (IVDD) Exosome‐Mediated Therapy for IVDD of Different Cell Sources Application of Engineered Exosomes in IVDD Clinical Application of Exosomes in IVDD Treatment Conclusion and Future Perspectives. Intervertebral disc degeneration (IVDD),
Xianglong Zhou +7 more
wiley +1 more source
CXCL12 enhances angiogenesis through CXCR7 activation in human umbilical vein endothelial cells
Scientific Reports, 2017 Angiogenesis is the process by which new vessels form from existing vascular networks. Human umbilical vein endothelial cells (HUVECs) may contribute to the study of vascular repair and angiogenesis. The chemokine CXCL12 regulates multiple cell functions,
Min Zhang +5 more
doaj +1 more source
High expression of CXCR4, CXCR7 and SDF-1 predicts poor survival in renal cell carcinoma
World Journal of Surgical Oncology, 2012 Background Chemokines and their receptors are known to play important roles in the tumorigenesis of many malignancies. The aim of this study was to evaluate the prognostic impact of the expression of the chemokine SDF-1 and its receptors CXCR4 and CXCR7 ...
Wang Linhui +7 more
doaj +1 more source
Evaluation of the role of downregulation of SNF5/INI1 core subunit of SWI/SNF complex in clear cell renal cell carcinoma development [PDF]
, 2017 Clear cell renal cell carcinoma (ccRCC) is characterized by stabilization of hypoxia-inducible factor (HIF1), and mutations in von Hippel-Lindau (VHL) gene.
Chrzan, A. +16 more
core
The role of circular RNAs in regulating cytokine signaling in cancer
FEBS Open Bio, Volume 15, Issue 9, Page 1436-1458, September 2025.Cytokines present in the tumor microenvironment fuel cancer development. Aberrant expression of circRNAs contributes to cancer progression. Cytokines are involved in regulating circRNA biogenesis. Furthermore, aberrantly expressed circRNAs regulate the expression of ligands, receptors, and downstream effectors involved in cytokine signaling to promote ...
Vandana Joshi +4 more
wiley +1 more source
The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells
Molecular Cancer, 2011 Background Migration of metastatic tumor cells from the bloodstream into lymph nodes is thought to be facilitated by expression of the chemokine receptors CCR7, CXCR4 and, for B cell-derived tumors, CXCR5. Expression of their respective chemokine ligands
Jaén Juan C +4 more
doaj +1 more source
Progress of anti-angiogenic therapy for brain tumors: new modality and resolution of the resistance [PDF]
, 2012 科学研究費助成事業(科学研究費補助金)研究成果報告書：基盤研究(B)2009-2011課題番号 ...
TAKANO SHINGO, 高野 晋吾
core
Chemokine receptor trio: CXCR3, CXCR4 and CXCR7 crosstalk via CXCL11 and CXCL12. [PDF]
, 2013 Although chemokines are well established to function in immunity and endothelial cell activation and proliferation, a rapidly growing literature suggests that CXC Chemokine receptors CXCR3, CXCR4 and CXCR7 are critical in the development and progression ...
Arya, R.K. +7 more
core +1 more source
Advanced Healthcare Materials, Volume 14, Issue 25, September 26, 2025.Most in vitro cancer models lack cellular diversity, functional complexity, and clinical relevance. This work highlights the generation of an innovative dynamic tetraculture with autologous patient‐derived cells within a vascularized tumor‐on‐chip, as well as the recapitulation of endothelial anergy features induced by the tumor microenvironment ...
Christine Lansche +16 more
wiley +1 more source
CXCR7 mediates angiogenesis in human glioma
, 2013 64. Jahrestagung der Deutschen Gesellschaft für Neurochirurgie (DGNC)
Guentchev, M +3 more
openaire +1 more source