Results 11 to 20 of about 10,590 (201)
Ubiquitination of CXCR7 controls receptor trafficking. [PDF]
PLoS ONE, 2012 The chemokine receptor CXCR7 binds CXCL11 and CXCL12 with high affinity, chemokines that were previously thought to bind exclusively to CXCR4 and CXCR3, respectively.
Meritxell Canals +5 more
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CXCR7 Targeting and Its Major Disease Relevance [PDF]
Frontiers in Pharmacology, 2018 Chemokine receptors are the target of small peptide chemokines. They play various important roles in physiological and pathological processes. CXCR7, later renamed ACKR3, is a non-classical seven transmembrane-spanning receptor whose function as a ...
Chuan Wang, Weilin Chen, Jianzhong Shen
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Advances in CXCR7 Modulators [PDF]
Pharmaceuticals, 2020 CXC chemokine receptor 7 (CXCR7) is a G-protein-coupled receptor that signals through the β-arrestin pathway. Its ligands include interferon-inducible T cell α chemoattractant (CXCL11) and stromal cell-derived factor-1 (CXCL12).
Nicole Lounsbury
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Imaging Ligand-Dependent Activation of CXCR7
Neoplasia: An International Journal for Oncology Research, 2009 Chemokine CXCL12 is proposed to promote multiple steps in growth of primary tumors and progression to metastatic disease in more than 20 different cancers.
Kathryn E. Luker +4 more
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CXCR7 functions as a scavenger for CXCL12 and CXCL11. [PDF]
PLoS ONE, 2010 BackgroundCXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses.
Ulrike Naumann +7 more
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CXCR7 Antagonism Reduces Acute Lung Injury Pathogenesis [PDF]
Frontiers in Pharmacology, 2021 Loss of control in the trafficking of immune cells to the inflamed lung tissue contributes to the pathogenesis of life-threatening acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS). Targeting CXCR7 has been proposed as a potential therapeutic approach to reduce pulmonary inflammation; however, its role and its
Laetitia Pouzol +6 more
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CXCR7 expression in esophageal cancer [PDF]
Journal of Translational Medicine, 2013 The chemokine CXCL12 and its receptor CXCR4 play a major role in tumor invasion, proliferation and metastasis in different malignant diseases, including esophageal carcinoma, amongst others. CXCR7 was recently identified as a novel alternate receptor for CXCL12.
Tachezy, Michael +6 more
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Endothelial CXCR7 regulates breast cancer metastasis [PDF]
Oncogene, 2015 Atypical chemokine receptor CXCR7 (ACKR3) functions as a scavenger receptor for chemokine CXCL12, a molecule that promotes multiple steps in tumor growth and metastasis in breast cancer and multiple other malignancies. Although normal vascular endothelium expresses low levels of CXCR7, marked upregulation of CXCR7 occurs in tumor vasculature in breast ...
Stacer, Amanda C. +8 more
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Stem Cell Research & Therapy, 2021 Background Endothelial progenitor cell (EPC) dysfunction contributes to vascular disease in diabetes mellitus. However, the molecular mechanism underlying EPC dysfunction and its contribution to delayed reendothelialization in diabetes mellitus remain ...
Chunyu Jiang +8 more
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Chemokine receptor CXCR7 is a functional receptor for CXCL12 in brain endothelial cells. [PDF]
PLoS ONE, 2014 The chemokine CXCL12 regulates multiple cell functions through its receptor, CXCR4. However, recent studies have shown that CXCL12 also binds a second receptor, CXCR7, to potentiate signal transduction and cell activity.
Yang Liu +2 more
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