Results 11 to 20 of about 10,559 (201)
Ubiquitination of CXCR7 controls receptor trafficking. [PDF]
PLoS ONE, 2012 The chemokine receptor CXCR7 binds CXCL11 and CXCL12 with high affinity, chemokines that were previously thought to bind exclusively to CXCR4 and CXCR3, respectively.
Meritxell Canals +5 more
doaj +5 more sources
CXCR7 Targeting and Its Major Disease Relevance [PDF]
Frontiers in Pharmacology, 2018 Chemokine receptors are the target of small peptide chemokines. They play various important roles in physiological and pathological processes. CXCR7, later renamed ACKR3, is a non-classical seven transmembrane-spanning receptor whose function as a ...
Chuan Wang, Weilin Chen, Jianzhong Shen
doaj +3 more sources
Advances in CXCR7 Modulators [PDF]
Pharmaceuticals, 2020 CXC chemokine receptor 7 (CXCR7) is a G-protein-coupled receptor that signals through the β-arrestin pathway. Its ligands include interferon-inducible T cell α chemoattractant (CXCL11) and stromal cell-derived factor-1 (CXCL12).
Nicole Lounsbury
doaj +3 more sources
Imaging Ligand-Dependent Activation of CXCR7
Neoplasia: An International Journal for Oncology Research, 2009 Chemokine CXCL12 is proposed to promote multiple steps in growth of primary tumors and progression to metastatic disease in more than 20 different cancers.
Kathryn E. Luker +4 more
doaj +3 more sources
CXCR7 Is Involved in Human Oligodendroglial Precursor Cell Maturation. [PDF]
PLoS ONE, 2016 Differentiation of oligodendroglial precursor cells (OPCs), a crucial prerequisite for central nervous system (CNS) remyelination in diseases such as Multiple Sclerosis (MS), is modulated by a multitude of extrinsic and intrinsic factors.
David Kremer +6 more
doaj +5 more sources
CXCR7 functions as a scavenger for CXCL12 and CXCL11. [PDF]
PLoS ONE, 2010 BackgroundCXCR7 (RDC1), the recently discovered second receptor for CXCL12, is phylogenetically closely related to chemokine receptors, but fails to couple to G-proteins and to induce typical chemokine receptor mediated cellular responses.
Ulrike Naumann +7 more
doaj +4 more sources
CXCR7 Antagonism Reduces Acute Lung Injury Pathogenesis [PDF]
Frontiers in Pharmacology, 2021 Loss of control in the trafficking of immune cells to the inflamed lung tissue contributes to the pathogenesis of life-threatening acute lung injury (ALI) and its more severe form, acute respiratory distress syndrome (ARDS). Targeting CXCR7 has been proposed as a potential therapeutic approach to reduce pulmonary inflammation; however, its role and its
Laetitia Pouzol +6 more
openaire +3 more sources
Decoy Receptors in Autoimmunity: Molecular Guardians and Pathogenic Players in Immune Dysregulation. [PDF]
Mediators InflammAutoimmune disorders encompass a varied range of diseases in which the immune system mistakenly targets and attacks the body’s own tissues. The causes of the conditions are unknown. It is presumed that various genetic, environmental, and immune factors all play a part.
Farahani H +4 more
europepmc +2 more sources
CXCR7 expression in esophageal cancer [PDF]
Journal of Translational Medicine, 2013 The chemokine CXCL12 and its receptor CXCR4 play a major role in tumor invasion, proliferation and metastasis in different malignant diseases, including esophageal carcinoma, amongst others. CXCR7 was recently identified as a novel alternate receptor for CXCL12.
Tachezy, Michael +6 more
openaire +2 more sources
Endothelial CXCR7 regulates breast cancer metastasis [PDF]
Oncogene, 2015 Atypical chemokine receptor CXCR7 (ACKR3) functions as a scavenger receptor for chemokine CXCL12, a molecule that promotes multiple steps in tumor growth and metastasis in breast cancer and multiple other malignancies. Although normal vascular endothelium expresses low levels of CXCR7, marked upregulation of CXCR7 occurs in tumor vasculature in breast ...
Stacer, Amanda C. +8 more
openaire +2 more sources