Results 51 to 60 of about 10,590 (201)
Cell & Bioscience, 2022 Background Chemokine CXC motif receptor 7 (CXCR7) is an atypical G protein-coupled receptor (GPCR) that signals in a biased fashion. CXCL12/CXCR7 biased signal has been reported to play crucial roles in multiple stages of colorectal cancer (CRC). However,
Mahan Si +7 more
doaj +1 more source
Molecular insights into intrinsic transducer-coupling bias in the CXCR4-CXCR7 system
Nature Communications, 2023 Chemokine receptors constitute an important subfamily of G protein-coupled receptors (GPCRs), and they are critically involved in a broad range of immune response mechanisms.
Parishmita Sarma +16 more
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Drug-releasing mesenchymal cells strongly suppress B16 lung metastasis in a syngeneic murine model [PDF]
, 2015 Mesenchymal stromal cells (MSCs) are considered an important therapeutic tool in cancer therapy. They possess intrinsic therapeutic potential and can also be in vitro manipulated and engineered to produce therapeutic molecules that can be delivered to ...
Alessandri, Giulio +21 more
core +2 more sources
What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands [PDF]
, 2019 Dipeptidyl peptidase 4 (DPP4) is an exopeptidase found either on cell surfaces where it is highly regulated in terms of its expression and surface availability (CD26) or in a free/circulating soluble constitutively available and intrinsically active form.
Aguilar-Pérez, Alexandra +13 more
core +1 more source
Scientific Reports, 2017 The atypical C-X-C chemokine receptor 7 (CXCR7) has been implicated in supporting aggressive cancer phenotypes in several cancers including prostate cancer.
James J. Hoy +3 more
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Journal of Experimental & Clinical Cancer Research, 2010 Background In spite of recent advances in diagnostic and therapeutic measures, the prognosis of hepatocellular carcinoma (HCC) patients remains poor.
Li Fan +6 more
doaj +1 more source
Frontiers in Oncology, 2021 The chemokine receptor 4 (CXCR4) and 7 (CXCR7) are G-protein-coupled receptors (GPCRs) activated through their shared ligand CXCL12 in multiple human cancers.
Sara Santagata +6 more
doaj +1 more source
Chemokines in the balance: Maintenance of homeostasis and protection at CNS barriers [PDF]
, 2014 In the adult central nervous system (CNS), chemokines and their receptors are involved in developmental, physiological and pathological processes. Although most lines of investigation focus on their ability to induce the migration of cells, recent ...
Holman, David W +2 more
core +3 more sources
Cxcr7 Controls Neuronal Migration by Regulating Chemokine Responsiveness [PDF]
Neuron, 2011 The chemokine Cxcl12 binds Cxcr4 and Cxcr7 receptors to control cell migration in multiple biological contexts, including brain development, leukocyte trafficking, and tumorigenesis. Both receptors are expressed in the CNS, but how they cooperate during migration has not been elucidated.
Sánchez-Alcañiz, Juan Antonio +8 more
openaire +3 more sources
CENPF Promotes EMT in Non-small Cell Lung Cancer by Up-regulating ACKR3/CXCR7
Zhongliu Fangzhi Yanjiu, 2022 Objective To investigate the relationship between the expression of CENPF in NSCLC adenocarcinoma (LUAD) and the clinical prognosis of patients and its effect on the metastasis of lung adenocarcinoma cells. Methods The expression of CENPF in LUAD and its
GU Tong +6 more
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