Results 81 to 90 of about 10,590 (201)

Screening the Active Phytochemicals From Eclipta prostrata and Unraveling Their Molecular Insight Into Human Malignancies

Cancer Innovation, Volume 4, Issue 6, December 2025.
This review comprehensively analyses the phytochemicals from Eclipta prostrata, identifying 25 active compounds with chemotherapeutic potential against 15 different human malignancies. These compounds modulate diverse and complex mechanisms, including targeting critical signaling pathways (e.g., PI3K/AKT/mTOR), inducing regulated cell death (e.g., FAS,
Md. Sakhawat Hossain, Sanzida Khatun, Md Mojnu Mia, Fatematuz Zohora, Md. Rifat Sarker, K. M. Tanjida Islam, Md. Abu Sayeed, Moushumi Afroza Mou, Sherif Hamidu, Fatima Hamidu, A. M. Wasaf Hasan, Sanjida Mumtaj, Md Khaled Hossain, Md Sohel   +13 more
wiley   +1 more source

Mechanisms of CXCR7 induction in malignant melanoma development

Oncology Letters, 2017
Malignant melanoma (MM) is a highly malignant skin tumor. The mechanism of MM pathogenesis and its signaling pathways are not well characterized. C-X-C chemokine receptor type 7 (CXCR7) has been reported to regulate cancer cell invasion. The present study sought to investigate the effects of CXCR7 on MM development.
Li, Xiao-Jing, Liu, Pai, Tian, Wei-Wei, Li, Zhi-Feng, Liu, Bao-Guo, Sun, Jian-Fang   +5 more
openaire   +3 more sources

CXCR7 stimulates MAPK signaling to regulate hepatocellular carcinoma progression [PDF]

Cell Death & Disease, 2014
AbstractThe CXCL12/CXCR4 axis has been posited widely to have significant roles in many primary tumors and metastases. It is known that CXCR7 can also be engaged by CXCL12, but the exact function of CXCR7 is controversial. This prompted us to investigate the expression, specific function and signal transduction of CXCR7 in hepatocellular carcinoma (HCC)
Lin, L, Han, M-M, Wang, F, Xu, L-L, Yu, H-X, Yang, P-Y   +5 more
openaire   +2 more sources

LPS-induced CXCR7 expression promotes gastric Cancer proliferation and migration via the TLR4/MD-2 pathway

Diagnostic Pathology, 2019
Background Lipopolysaccharide (LPS) from Helicobacter pylori (HP) plays an important role in gastric cancer occurrence and development. Toll-like receptor 4 (TLR4) and myeloid differential protein-2 (MD-2) are also reported to be involved in gastric ...
Nan Li, Huanbai Xu, Yurong Ou, Zhenzhong Feng, Qiong Zhang, Qing Zhu, Zhaogen Cai   +6 more
doaj   +1 more source

Overexpression of CXCR7 accelerates tumor growth and metastasis of lung cancer cells

Respiratory Research, 2020
Background Under physiological conditions, CXCL12 modulates cell proliferation, survival, angiogenesis, and migration mainly through CXCR4. Interestingly, the newly discovered receptor CXCR7 for CXCL12 is highly expressed in many tumor cells as well as ...
Huan Liu, Qian Cheng, Dong-sheng Xu, Wen Wang, Zheng Fang, Dong-dong Xue, Ya Zheng, Alex H. Chang, Yan-jun Lei   +8 more
doaj   +1 more source

Aberrant proliferation in CXCR7+ endothelial cells via degradation of the retinoblastoma protein. [PDF]

PLoS ONE, 2013
Angiogenesis is a critical factor in the growth and dissemination of solid tumors. Indeed, tumor vasculature is abnormal and contributes to the development and spread of malignancies by creating a hostile microenvironment.
Jennifer E Totonchy, Jessica M Osborn, Sara Botto, Lisa Clepper, Ashlee V Moses   +4 more
doaj   +1 more source

Hypoxic Culture Conditions as a Solution for Mesenchymal Stem Cell Based Regenerative Therapy [PDF]

, 2014
Cell-based regenerative therapies, based on in vitro propagation of stem cells, offer tremendous hope to many individuals suffering from degenerative diseases that were previously deemed untreatable.
Abu Kasim, N. H., Alabsi, A. M., Haque, N., Rahman, M. T.   +3 more
core   +1 more source

Activation and Long‐Term Maintenance of Adaptive Immunity in the Central Nervous System: A Double‐Edged Sword?

CNS Neuroscience &Therapeutics, Volume 31, Issue 12, December 2025.
A wide spectrum of cells in the brain can engage in antigen presentation, which activates adaptive immunity in the central nervous system (CNS). Tissue‐resident memory T cells (TRM) develop in adaptive immunity in the CNS and provide long‐term immune surveillance, including the clearance of pathogens and tumor cells.
Luojinyun Wang, Feng Zhang, Jiehong Wu, Sibo Yang, Daqiang Zhou, Xiaodi Sun, Bohao Chang, Bo Hu, Yifan Zhou   +8 more
wiley   +1 more source

Rhabdomyosarcoma: Advances in Molecular and Cellular Biology. [PDF]

, 2015
Rhabdomyosarcoma (RMS) is the most common soft tissue malignancy in childhood and adolescence. The two major histological subtypes of RMS are alveolar RMS, driven by the fusion protein PAX3-FKHR or PAX7-FKHR, and embryonic RMS, which is usually ...
Duan, Zhenfeng, Guo, Wei, Hornicek, Francis J, Mankin, Henry J, Shen, Jacson K, Sun, Xin   +5 more
core   +3 more sources

Stromal cell‐derived factor‐1 regulates expression of vascular endothelial growth factor and osteopontin after tooth extraction

Journal of Periodontology, Volume 96, Issue 12, Page 1391-1399, December 2025.
Abstract Background The present study aimed to investigate the expression of stromal cell‐derived factor‐1 (SDF‐1) after tooth extraction in rats and its regulatory effect on the expression of osteopontin (OPN) and vascular endothelial growth factor (VEGF).
Jingjing Kong, Lei Li, Fei Gao, Kaiqi Zhang, Jianli Xie, Jun Cui   +5 more
wiley   +1 more source