Results 81 to 90 of about 10,559 (201)

Mechanisms of CXCR7 induction in malignant melanoma development

Oncology Letters, 2017
Malignant melanoma (MM) is a highly malignant skin tumor. The mechanism of MM pathogenesis and its signaling pathways are not well characterized. C-X-C chemokine receptor type 7 (CXCR7) has been reported to regulate cancer cell invasion. The present study sought to investigate the effects of CXCR7 on MM development.
Li, Xiao-Jing, Liu, Pai, Tian, Wei-Wei, Li, Zhi-Feng, Liu, Bao-Guo, Sun, Jian-Fang   +5 more
openaire   +3 more sources

CXCR7 stimulates MAPK signaling to regulate hepatocellular carcinoma progression [PDF]

Cell Death & Disease, 2014
AbstractThe CXCL12/CXCR4 axis has been posited widely to have significant roles in many primary tumors and metastases. It is known that CXCR7 can also be engaged by CXCL12, but the exact function of CXCR7 is controversial. This prompted us to investigate the expression, specific function and signal transduction of CXCR7 in hepatocellular carcinoma (HCC)
Lin, L, Han, M-M, Wang, F, Xu, L-L, Yu, H-X, Yang, P-Y   +5 more
openaire   +2 more sources

LPS-induced CXCR7 expression promotes gastric Cancer proliferation and migration via the TLR4/MD-2 pathway

Diagnostic Pathology, 2019
Background Lipopolysaccharide (LPS) from Helicobacter pylori (HP) plays an important role in gastric cancer occurrence and development. Toll-like receptor 4 (TLR4) and myeloid differential protein-2 (MD-2) are also reported to be involved in gastric ...
Nan Li, Huanbai Xu, Yurong Ou, Zhenzhong Feng, Qiong Zhang, Qing Zhu, Zhaogen Cai   +6 more
doaj   +1 more source

Overexpression of CXCR7 accelerates tumor growth and metastasis of lung cancer cells

Respiratory Research, 2020
Background Under physiological conditions, CXCL12 modulates cell proliferation, survival, angiogenesis, and migration mainly through CXCR4. Interestingly, the newly discovered receptor CXCR7 for CXCL12 is highly expressed in many tumor cells as well as ...
Huan Liu, Qian Cheng, Dong-sheng Xu, Wen Wang, Zheng Fang, Dong-dong Xue, Ya Zheng, Alex H. Chang, Yan-jun Lei   +8 more
doaj   +1 more source

Aberrant proliferation in CXCR7+ endothelial cells via degradation of the retinoblastoma protein. [PDF]

PLoS ONE, 2013
Angiogenesis is a critical factor in the growth and dissemination of solid tumors. Indeed, tumor vasculature is abnormal and contributes to the development and spread of malignancies by creating a hostile microenvironment.
Jennifer E Totonchy, Jessica M Osborn, Sara Botto, Lisa Clepper, Ashlee V Moses   +4 more
doaj   +1 more source

Structure and functional motifs of GCR1, the only plant protein with a GPCR fold? [PDF]

, 2013
Whether GPCRs exist in plants is a fundamental biological question. Interest in deorphanizing new G protein coupled receptors (GPCRs), arises because of their importance in signaling.
Abdalla, Nuradin Y, Bailey, Gregory R, Jordon, Sian R D, Reeves, Philip J, Reynolds, Christopher A, Taddese, Bruck, Upton, Graham J G   +6 more
core   +1 more source

Bevacizumab in ovarian cancer: Clinical data and predictive and prognostic biomarkers

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Evidence supporting bevacizumab in ovarian cancer and predictive biomarkers: highlighting opportunities to improve patient selection and advance personalised treatment strategies. Abstract Angiogenesis, driven by the vascular endothelial growth factor (VEGF)/VEGFR signalling axis under hypoxic conditions, is one of the hallmarks of ovarian cancer (OC),
Maria Rosaria Lamia, Erica Perri, Gustavo Baldassarre, Sandro Pignata, Chiara D'Alessio, Davide Limongello, Francesca Basso‐Valentina   +6 more
wiley   +1 more source

Endothelial CD276 (B7-H3) expression is increased in human malignancies and distinguishes between normal and tumour-derived circulating endothelial cells [PDF]

, 2014
Background:Mature circulating endothelial cells (CEC) are surrogate markers of endothelial damage. CEC measured in patients with advanced cancer are thought not only to derive from damaged normal vasculature (n-CEC ...
A Ouhtit, AI Chapoval, AW Griffioen, B Croix St, C Verhoef, D J Grunhagen, D Lemke, DM McDonald, F Bertolini, F Dignat-George, GN Naumov, HR Lijnen, I Yamato, J Hagendoorn, J Kraan, J Kraan, J Kraan, J W Gratama, JA Nagy, JL Rowand, K Broll, K Hida, KH Plate, L Zimmerlin, M Crisan, MH Strijbos, N Maishi, P Carmeliet, P Steinberger, P van den Broek, PK Goon, PL Crispen, R Minhajat, R Wurth, S Seaman, S Sleijfer, SE Duff, TJ Roth, W Taal, X Qin, X Zang, Y Sun, YQ Xiong   +42 more
core   +4 more sources

CXCR7 contributes to the aggressive phenotype of cholangiocarcinoma cells [PDF]

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2019
Development of cholangiocarcinoma (CCA) is dependent on a cross-talk with stromal cells, which release different chemokines including CXCL12, that interacts with two different receptors, CXCR4 and CXCR7. The aim of the present study was to investigate the role of CXCR7 in CCA cells.
Alessandra Gentilini, Alessandra Caligiuri, Chiara Raggi, Krista Rombouts, Massimo Pinzani, Giulia Lori, Margherita Correnti, Pietro Invernizzi, Elisabetta Rovida, Nadia Navari, Sabina Di Matteo, Domenico Alvaro, Jesus M. Banales, Pedro Rodrigues, Carlotta Raschioni, Matteo Donadon, Luca Di Tommaso, Fabio Marra   +17 more
openaire   +7 more sources

Niche inheritance: a cooperative pathway to enhance cancer cell fitness though ecosystem engineering [PDF]

, 2014
Cancer cells can be described as an invasive species that is able to establish itself in a new environment. The concept of niche construction can be utilized to describe the process by which cancer cells terraform their environment, thereby engineering ...
Barar J, Elton CS, Faraji F, Fidler IJ, Folkman J, Gatenby RA, Healy M, Hutchinson GE, Odling‐Smee FJ, Odling‐Smee FJ, Paget S, Pienta KJ, Weiss L, Wey JS   +13 more
core   +2 more sources