Results 131 to 140 of about 72,449 (334)

Cell-cycle-related changes of 3':5'-cyclic GMP levels in Novikoff hepatoma cells. [PDF]

, 1977
Charles E. Zeilig, N D Goldberg
openalex   +1 more source

Targeting HDAC and PARP Enhances STING‐Dependent Antitumor Immunity in STING‐Deficient Tumor

Advanced Science, EarlyView.
Dual HDAC and PARP inhibition restores STING signaling, enhances interferon response, and boosts antitumor immunity in STING‐deficient tumors. . Abstract The stimulator of interferon genes (STING)‐mediated innate immune pathway plays an important role in tumor immunosurveillance.
Chengzhou Mao, Weiwen Fan, Jiaqi Liu, Fangzhou Yang, Wenkai Li, Lulu Li, Zhichao Shi, Qinyuan Li, Zigao Yuan, Yuyang Jiang, Bizhu Chu   +10 more
wiley   +1 more source

Structure-based virtual screening and in vitro validation of inhibitors of cyclic dinucleotide phosphodiesterases ENPP1 and CdnP

Microbiology Spectrum
Cyclic GMP-AMP synthase (cGAS) and stimulator of interferon genes (STING) are intracellular mediators of innate immune responses to cytosolic pathogen-derived and host DNA.
Akshay Rohilla, Alok Kumar Singh, Benjamin Koleske, Geetha Srikrishna, William R. Bishai   +4 more
doaj   +1 more source

Novel Mechanism by Which Extracellular Cyclic GMP Induces Natriuresis. [PDF]

Circ Res, 2023
Bulger DA, Griendling KK.
europepmc   +1 more source

Centimeter‐Scale Self‐Assembling Tendon Organoids Drive Tissue Regeneration

Advanced Science, EarlyView.
Centimeter‐scale tendon organoids are engineered by mimicking the extracellular matrix and optimizing chemical cues to guide tendon stem/progenitor cells. These large, self‐assembling constructs overcome conventional size limitations and exhibit enhanced tenogenic differentiation, extracellular matrix production, and mechanical resilience. Their tissue‐
Tianshun Fang, Hong Zhang, Yuanhao Xie, Xiongfeng Li, Xi Liu, Zichen Wang, Yiwen Xue, Xiaohui Xia, Zetao Wang, Tingyun Lei, Ruifu Lin, Weiliang Shen, Bingbing Wu, Yishan Chen, Yanan Du, Xiao Chen, Zi Yin   +16 more
wiley   +1 more source

The global regulation of c‐di‐GMP and cAMP in bacteria

mLife
Nucleotide second messengers are highly versatile signaling molecules that regulate a variety of key biological processes in bacteria. The best‐studied examples are cyclic AMP (cAMP) and bis‐(3′–5′)‐cyclic dimeric guanosine monophosphate (c‐di‐GMP ...
Cong Liu, Rui Shi, Marcus S. Jensen, Jingrong Zhu, Jiawen Liu, Xiaobo Liu, Di Sun, Weijie Liu   +7 more
doaj   +1 more source

Concentration-dependent vascular effects of divalent manganese [PDF]

, 2015
Oral Presentation: no. OP9OBJECTIVES: Divalent manganese is a cofactor for soluble guanylyl cyclase (sGC), the enzyme producing cyclic GMP in vascular smooth muscle cells that causes relaxation. Manganese competes with magnesium to activate sGC.
Detremmerie, CMS, Leung, SWS, Vanhoutte, PM   +2 more
core  

Emerging cGAS‐STING Agonist‐Based Nanotherapeutics: Mechanistic Insights and Applications in Cancer Combination Therapy

Advanced Science, EarlyView.
This review summarizes recent advances in cGAS‐STING agonist‐based nanotherapeutics for cancer combination therapy. It explores nanoparticle‐mediated delivery strategies, underlying molecular mechanisms, and combinatorial applications with chemotherapy, radiotherapy, targeted therapy, phototherapy, sonodynamic therapy, and immunotherapy.
Zhaomeng Wang, Yongjun Wang, Zhonggui He, Caigang Liu   +3 more
wiley   +1 more source

Hypoxic erythrocytes mediate cardioprotection through activation of soluble guanylate cyclase and release of cyclic GMP. [PDF]

J Clin Invest, 2023
Yang J, Sundqvist ML, Zheng X, Jiao T, Collado A, Tratsiakovich Y, Mahdi A, Tengbom J, Mergia E, Catrina SB, Zhou Z, Carlström M, Akaike T, Cortese-Krott MM, Weitzberg E, Lundberg JO, Pernow J.   +16 more
europepmc   +1 more source

Illuminating the Unseen and Targeting the Untreatable: Aggregation‐Induced Emission Nanoparticles as Intelligent, Immune‐Compatible Tools for Precision Cancer Theranostics

Aggregate, EarlyView.
Rationally engineered AIE nanoparticles can unite deep‐tissue imaging, photodynamic therapy, photothermal therapy, and immune microenvironment reprogramming. Through precise photophysical tuning and targeted delivery, these intelligent nanoplatforms enable real‐time monitoring, potent tumor eradication, and immune activation, offering a versatile and ...
Quazi T. H. Shubhra, Robert Musiol, Huachun Pan, Qiang Cai, Xiaosong He, Xiaojun Cai   +5 more
wiley   +1 more source