British Journal of Clinical Pharmacology, EarlyView.People accessing aged care services are increasingly older and often experience multimorbidity and polypharmacy, which puts them at risk of medication‐related harm. Quality indicators (QIs) can assist with monitoring, benchmarking and informing initiatives to reduce medication‐related harm.
Daria S. Gutteridge +20 more
wiley +1 more source
Cyclic GMP modulating drugs in cardiovascular diseases: mechanism-based network pharmacology. [PDF]
Cardiovasc Res, 2022 Petraina A +9 more
europepmc +1 more source
Ca2+-independent cyclic GMP phosphodiesterases from rat liver and HTC hepatoma cells [PDF]
, 1983 Gordon J Strewler +3 more
openalex +1 more source
Dinucleoside Polyphosphates in Cellular Signaling: Function and Evolution Across Life
BioEssays, EarlyView.Although discovered more than 50 years ago, the cellular functions of Ap4A and related dinucleotides remain largely enigmatic. To address this knowledge gap, we organized a conference showcasing recent research that highlights the critical role of Ap4A as a global regulator across all domains of life.
Gert Bange +5 more
wiley +1 more source
High-Intensity Interval Training Ameliorates High-Fat Diet-Induced Metabolic Disorders via the Cyclic GMP-AMP Synthase-Stimulator of Interferon Gene Signaling Pathway. [PDF]
Int J Mol Sci, 2023 Hu Z, Li X, Yang Y, Zhang Z, Ding S.
europepmc +1 more source
Influence of blood pressure, heart rate, age, and sex on concentrations of atrial natriuretic factor and cyclic GMP in 124 volunteers. [PDF]
, 1989 Marion Wencker +3 more
openalex +1 more source
From Genome to Geroscience: How DNA Damage Shapes Systemic Decline
BioEssays, EarlyView.Persistent DNA damage triggers systemic secretory responses including damage‐associated molecular patterns (DAMPs), the senescence‐associated secretory phenotype (SASP), and extracellular vesicles (EVs). This non‐cell‐autonomous signaling disrupts intercellular communication, driving organism‐wide dysfunction and aging, and offering new therapeutic ...
Athanasios Siametis, George A. Garinis
wiley +1 more source
Receptor Guanylyl Cyclase C and Cyclic GMP in Health and Disease: Perspectives and Therapeutic Opportunities. [PDF]
Front Endocrinol (Lausanne), 2022 Prasad H, Mathew JKK, Visweswariah SS.
europepmc +1 more source
BMEMat, EarlyView.This review highlights the complex roles of cellular senescence in cancer progression and suppression, discusses the mechanisms and regulatory pathways involved, and evaluates the efficacy of the “One‐Two punch” sequential treatment approach while addressing emerging challenges in this novel therapeutic strategy.
Qiuming Pan +12 more
wiley +1 more source
The Porcine Cyclic GMP-AMP Synthase-STING Pathway Exerts an Unusual Antiviral Function Independent of Interferon and Autophagy. [PDF]
J Virol, 2022 Jiang S +12 more
europepmc +1 more source