Results 201 to 210 of about 36,202 (265)

Expanded Functional Characterization and Optimization of Protein Expression in Treponema denticola Shuttle Plasmids

Molecular Oral Microbiology, Volume 41, Issue 2, Page 69-84, April 2026.
We report optimization of the Treponema denticola shuttle plasmid system by minimizing its size and by characterizing an array of promoter‐gene constructs for genetic complementation, including the first use in Treponema of a Tet‐inducible system for controlled expression of potentially toxic genes.
M. Paula Goetting‐Minesky, Valentina Godovikova, Prakaimuk Saraithong, Alexander H. Rickard, Brigette R. Crawley, Sara M. Agolli, Reagan L. Boyce, Trishna L. Appaji, J. Christopher Fenno   +8 more
wiley   +1 more source

Polylimonene Improves the In Vivo Wound Healing Performance of Sodium Alginate‐Based Hydrogels

Journal of Applied Polymer Science, Volume 143, Issue 12, March 20, 2026.
An oligomer derived from orange peel essential oil incorporated into an alginate hydrogel was shown to be biocompatible and to exhibit a high capacity for in vivo incisional wound healing, as confirmed by experimental assays and mathematical models fitted to the data describing wound area reduction as a function of the dressing‐tissue contact time ...
Roniérik Pioli Vieira, Guilherme Frey Schutz, Oana‐Maria Chirliu, Aurelian‐Sorin Pasca, Lenuta Profire, Sandra Van Vlierberghe   +5 more
wiley   +1 more source

Biochemical Engineering Perspective on cGAS: From Enzyme Discovery to Potential Industrial Application

ChemBioChem, Volume 27, Issue 5, 13 March 2026.
This review examines the structural and enzymatic properties of cyclic GMP‐AMP synthase, including substrate promiscuity, homologs, and engineered variants. In addition, it evaluates potential expression systems for large‐scale enzyme production and analyzes reaction and purification strategies for the synthesis of cyclic dinucleotides to connect ...
Makram Fataeri, Katrin Rosenthal
wiley   +1 more source

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Cyclic GMP transporters

Neurochemistry International, 2004
The biokinetics of guanosine 3',5'-cyclic monophosphate (cGMP) is characterized by three distinct processes: synthesis by guanylate cyclases (GCs), conversion of cGMP to GMP by cyclic nucleotide phosphodiesterases (PDEs) and the excretion of unchanged cGMP by transport proteins in the cell membrane.
openaire   +2 more sources

Cyclic GMP-Hydrolyzing Phosphodiesterases

2009
The cyclic nucleotides (cN), cAMP and cGMP, are key second messengers that mediate the intracellular effects of many signals known as “first messengers”, including environmental signals such as photons for vision and chemicals for taste, as well as hormones, paracrine factors, neurotransmitters, or autocrine factors.
Sharron H, Francis, Jackie D, Corbin, Erwin, Bischoff   +2 more
openaire   +2 more sources

Cyclic AMP and cyclic GMP in hyperresponsiveness

Life Sciences, 1988
Cyclic-AMP has been shown to cause a hyperresponse in blood pressure change in conjunction with norepinephrine in the anesthetized rat system. Recent experiments show that the antagonist to angiotensin II, Sar1-Thr8 angiotensin II, abolishes the hyperresponse produced by c-AMP.
H T, Miller, W, Yesus, T, Cooper, S, Harwell   +3 more
openaire   +2 more sources

Intracellular cyclic GMP receptor proteins

The FASEB Journal, 1993
Cyclic GMP is recognized as an important intracellular mediator of extracellular signals such as nitric oxide and natriuretic peptides. Cyclic GMP interacts with three types of intracellular receptor proteins: cGMP‐dependent protein kinases, cGMP‐regulated ion channels, and cGMP‐regulated cyclic nucleotide phosphodiesterases.
T M, Lincoln, T L, Cornwell
openaire   +2 more sources

Cyclic GMP and Cell Movement

Nature, 1973
THE movement of mammalian cells can be inhibited by agents which mimic or produce increases in the intracellular levels of cyclic 3′,5′-adenosine monophosphate (cyclic AMP)1,2. Goldberg and coworkers3,4 have proposed that in a number of cell types cyclic 3′,5′-guanosine monophosphate (cyclic GMP) promotes cellular events that are antagonistic to those ...
R D, Estensen, H R, Hill, P G, Quie, N, Gogan, N D, Goldberg   +4 more
openaire   +2 more sources

Cyclic GMP signaling in podocytes

Microscopy Research and Technique, 2002
AbstractNatriuretic peptides (NP), together with nitric oxide (NO) are powerful relaxing factors acting via a common second messenger, cyclic GMP (cGMP). Together with other vasoactive modulators, these vasorelaxing factors play an essential role in regulating the function of kidney glomeruli.
Barbara, Lewko, Jan, Stepinski
openaire   +2 more sources