Results 11 to 20 of about 1,721,329 (334)

Cyclic peptide structure prediction and design using AlphaFold

bioRxiv, 2023
Deep learning networks offer considerable opportunities for accurate structure prediction and design of biomolecules. While cyclic peptides have gained significant traction as a therapeutic modality, developing deep learning methods for designing such ...
Stephen A. Rettie, Katelyn V. Campbell, A. Bera, A. Kang, Simon Kozlov, Joshmyn De La Cruz, V. Adebomi, Guangfeng Zhou, F. DiMaio, S. Ovchinnikov, G. Bhardwaj   +10 more
semanticscholar   +1 more source

The cyclic peptide G4CP2 enables the modulation of galactose metabolism in yeast by interfering with GAL4 transcriptional activity

Frontiers in Molecular Biosciences, 2023
Genetically-encoded combinatorial peptide libraries are convenient tools to identify peptides to be used as therapeutics, antimicrobials and functional synthetic biology modules. Here, we report the identification and characterization of a cyclic peptide,
Stefano Rosa, Andrea Tagliani, Chiara Bertaso, Luca Tadini, Cristina Visentin, Louise Jane Gourlay, Sabrina Pricl, Sabrina Pricl, Lucia Feni, Sara Pellegrino, Paolo Pesaresi, Simona Masiero   +11 more
doaj   +1 more source

Cyclic peptide drugs approved in the last two decades (2001–2021)

RSC Chemical Biology, 2021
In contrast to the major families of small molecules and antibodies, cyclic peptides, as a family of synthesizable macromolecules, have distinct biochemical and therapeutic properties for pharmaceutical applications.
Huiya Zhang, Shiyu Chen
semanticscholar   +1 more source

Cyclic Opioid Peptides [PDF]

Current Medicinal Chemistry, 2016
For decades the opioid receptors have been an attractive therapeutic target for the treatment of pain. Since the first discovery of enkephalin, approximately a dozen endogenous opioid peptides have been known to produce opioid activity and analgesia, but their therapeutics have been limited mainly due to low blood brain barrier penetration and poor ...
Michael, Remesic, Yeon Sun, Lee, Victor J, Hruby   +2 more
openaire   +2 more sources

Cyclization and Docking Protocol for Cyclic Peptide–Protein Modeling Using HADDOCK2.4

Journal of Chemical Theory and Computation, 2022
An emerging class of therapeutic molecules are cyclic peptides with over 40 cyclic peptide drugs currently in clinical use. Their mode of action is, however, not fully understood, impeding rational drug design.
Vicky Charitou, Siri C. van Keulen, A. Bonvin   +2 more
semanticscholar   +1 more source

Efficient 3D conformer generation of cyclic peptides formed by a disulfide bond

Journal of Cheminformatics, 2022
Cyclic peptides formed by disulfide bonds have been one large group of common drug candidates in drug development. Structural information of a peptide is essential to understand its interaction with its target.
Huanyu Tao, Qilong Wu, Xuejun Zhao, Peicong Lin, Sheng-You Huang   +4 more
doaj   +1 more source

Improvement on Permeability of Cyclic Peptide/Peptidomimetic: Backbone N-Methylation as A Useful Tool

Marine Drugs, 2021
Peptides have a three-dimensional configuration that can adopt particular conformations for binding to proteins, which are well suited to interact with larger contact surface areas on target proteins.
Yang Li, Wang Li, Zhengshuang Xu
semanticscholar   +1 more source

Screening technology of cyclic peptide library based on gene encoding

Medicine in Drug Discovery, 2022
As a powerful tool for the discovery of peptide compounds, high-throughput library screening technology can also perform multitarget screening with high chemical diversity as a condition, which accelerates the process of exploring high-affinity peptide ...
Yangqiang Chen, Chonggang Duan, Kai Chen, Shumeng Sun, Daizhou Zhang, Xiangjing Meng   +5 more
doaj   +1 more source

Identification and functional analysis of novel precursor genes in cyclic peptide biosynthesis in Pseudostellaria heterophylla. [PDF]

BMC Plant Biol
Xu J, Zheng W, Ou X, He H, Yang C, Guo L, Xiao C, Jiang W, Shu G, Zhou T.   +9 more
europepmc   +3 more sources

A Rapid and Efficient Building Block Approach for Click Cyclization of Peptoids

Frontiers in Chemistry, 2020
Cyclic peptide-peptoid hybrids possess improved stability and selectivity over linear peptides and are thus better drug candidates. However, their synthesis is far from trivial and is usually difficult to automate.
Mamidi Samarasimhareddy, Mai Shamir, Deborah E. Shalev, Deborah E. Shalev, Mattan Hurevich, Assaf Friedler   +5 more
doaj   +1 more source