Results 11 to 20 of about 157,149 (239)
Efficient 3D conformer generation of cyclic peptides formed by a disulfide bond
Journal of Cheminformatics, 2022 Cyclic peptides formed by disulfide bonds have been one large group of common drug candidates in drug development. Structural information of a peptide is essential to understand its interaction with its target.
Huanyu Tao +4 more
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Rapid in silico Design of Potential Cyclic Peptide Binders Targeting Protein-Protein Interfaces
Frontiers in Chemistry, 2020 Rational design of specific inhibitors of protein-protein interactions is desirable for drug design to control cellular signal transduction but also for studying protein-protein interaction networks.
Brianda L. Santini, Martin Zacharias
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Screening technology of cyclic peptide library based on gene encoding
Medicine in Drug Discovery, 2022 As a powerful tool for the discovery of peptide compounds, high-throughput library screening technology can also perform multitarget screening with high chemical diversity as a condition, which accelerates the process of exploring high-affinity peptide ...
Yangqiang Chen +5 more
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A Rapid and Efficient Building Block Approach for Click Cyclization of Peptoids
Frontiers in Chemistry, 2020 Cyclic peptide-peptoid hybrids possess improved stability and selectivity over linear peptides and are thus better drug candidates. However, their synthesis is far from trivial and is usually difficult to automate.
Mamidi Samarasimhareddy +5 more
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Molecules, 2021 Through a simple 1,3-cycloaddition reaction, three BODIPY-peptide conjugates that target the extracellular domain of the epidermal growth factor receptor (EGFR) were prepared and their ability for binding to EGFR was investigated.
Tyrslai M. Williams +5 more
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Cyclic Peptides for the Treatment of Cancers: A Review
Molecules, 2022 Cyclic peptides have been widely reported to have therapeutic abilities in the treatment of cancer. This has been proven through in vitro and in vivo studies against breast, lung, liver, colon, and prostate cancers, among others.
Dalifa Ramadhani +3 more
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Clinics, 2011 INTRODUCTION: Epstein-Barr virus exposure appears to be an environmental trigger for rheumatoid arthritis that interacts with other risk factors. Relationships among anti-cyclic citrullinated peptide antibodies, the shared epitope, and smoking status ...
Michel Alexandre Yazbek +5 more
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Anion recognition by cyclic peptides [PDF]
Chemical Communications, 2015 Cyclic peptides provide excellent scaffolds for anion recognition and improved binding affinity and selectivity has been achieved through peptide backbone rigidification and the introduction of side chains bearing anion recognition groups.
Elmes, Robert B. P. +1 more
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Peptide oligomers from ultra-short peptides using sortase
Biochemistry and Biophysics Reports, 2017 Sortase A catalyzed ligation of ultra-short peptides leads to inter/intra-molecular transpeptidation to form either linear or cyclic oligomers dependent upon the peptide length.
Natalya Voloshchuk +3 more
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Directed Evolution of Bicyclic Peptides for Therapeutic Application
CHIMIA, 2013 Many naturally occurring cyclic peptides or derivatives thereof are used as therapeutics such as the human hormones vasopressin and oxytocin or the antibiotics vancomycin and daptomycin.
Philippe Diderich, Christian Heinis
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