Cyclophilin B serum levels present variations across the menstrual cycle [PDF]
Scientific Reports, 2023 Cyclophilins are a family of chaperones involved in inflammation and cell death. Cyclophilin B is released by inflammatory cells and acts through the receptor CD147, affecting matrix metalloproteases release, whilst cyclophilin D participates in hypoxia ...
Rebeca Alvariño +7 more
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Cyclophilin B facilitates the replication of Orf virus [PDF]
Virology Journal, 2017 Background Viruses interact with host cellular factors to construct a more favourable environment for their efficient replication. Expression of cyclophilin B (CypB), a cellular peptidyl-prolyl cis-trans isomerase (PPIase), was found to be significantly ...
Kui Zhao +7 more
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Accelerated Aging in Cyclophilin B–Deficient Mice Downstream of p21‐Cip1/Waf1 [PDF]
JBMR Plus, 2022 Loss of bone mass and strength is a common problem of advanced age in humans. Defective bone is also a primary finding in osteogenesis imperfecta (OI), a genetic condition most commonly caused by autosomal dominant mutations in the type I collagen genes.
Ying Zhang +2 more
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Sanglifehrin A mitigates multiorgan fibrosis by targeting the collagen chaperone cyclophilin B [PDF]
JCI InsightPathological deposition and crosslinking of collagen type I by activated myofibroblasts drives progressive tissue fibrosis. Therapies that inhibit collagen synthesis have potential as antifibrotic agents.
Hope A. Flaxman +13 more
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Cyclophilin B enhances HIV-1 infection. [PDF]
Virology, 2016 Cyclophilin B (CypB) is a member of the immunophilin family and intracellular chaperone. It predominantly localizes to the ER, but also contains a nuclear localization signal and is secreted from cells. CypB has been shown to interact with the Gag protein of human immunodeficiency type 1 (HIV-1). Several proteomic and genetic studies identified it as a
DeBoer J, Madson CJ, Belshan M.
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Feline coronavirus replication is affected by both cyclophilin A and cyclophilin B. [PDF]
J Gen Virol, 2017 Feline coronavirus (FCoV) causes the fatal disease feline infectious peritonitis, which is currently incurable by drug treatment, and no effective vaccines are available. Cyclosporin A (CsA), a cyclophilin (Cyp) inhibitor, inhibits the replication of FCoV in vitro and in vivo as well as the replication of human and animal coronaviruses.
Tanaka Y, Sato Y, Sasaki T.
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Severe osteogenesis imperfecta in cyclophilin B-deficient mice. [PDF]
PLoS Genetics, 2009 Osteogenesis Imperfecta (OI) is a human syndrome characterized by exquisitely fragile bones due to osteoporosis. The majority of autosomal dominant OI cases result from point or splice site mutations in the type I collagen genes, which are thought to ...
Jae Won Choi +8 more
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Cyclosporine A-sensitive, cyclophilin B-dependent endoplasmic reticulum-associated degradation. [PDF]
PLoS ONE, 2010 Peptidyl-prolyl cis/trans isomerases (PPIs) catalyze cis/trans isomerization of peptide bonds preceding proline residues. The involvement of PPI family members in protein refolding has been established in test tube experiments.
Riccardo Bernasconi +5 more
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Human Cyclophilin B Nuclease Activity Revealed via Nucleic Acid-Based Electrochemical Sensors. [PDF]
Angew Chem Int Ed Engl, 2022 AbstractHuman cyclophilin B (CypB) is oversecreted by pancreatic cancer cells, making it a potential biomarker for early‐stage disease diagnosis. Our group is motivated to develop aptamer‐based assays to measure CypB levels in biofluids. However, human cyclophilins have been postulated to have collateral nuclease activity, which could impede the use of
Clark V +7 more
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Mice lacking cyclophilin B, but not cyclophilin A, are protected from the development of NASH in a diet and chemical-induced model. [PDF]
PLoS ONECyclophilins are a diverse family of peptidyl-prolyl isomerases (PPIases) of importance in a variety of essential cellular functions. We previously reported that the pan-cyclophilin inhibitor drug reconfilstat (CRV431) decreased disease in mice under the
Winston T Stauffer +5 more
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