Results 11 to 20 of about 45,384 (211)

High-fat diet induced cyclophilin B enhances STAT3/lncRNA-PVT1 feedforward loop and promotes growth and metastasis in colorectal cancer [PDF]

Cell Death and Disease, 2022
High-fat diet (HFD) has been implicated to promote colorectal cancer (CRC). Recently, oncogene Cyclophilin B (CypB) is reported to be induced by cholesterol.
Hanqing Guo, Kun Zhuang, Ning Ding, Rui Hua, Hailing Tang, Yue Wu, Zuyi Yuan, Ting Li, Shuixiang He   +8 more
doaj   +2 more sources

Human Cyclophilin B forms part of a multi-protein complex during erythrocyte invasion by Plasmodium falciparum [PDF]

Nature Communications, 2017
Invasion of red blood cells by Plasmodium falciparum is a complex process and relies on several receptor-ligand interactions. Here, the authors show that human cyclophilin B binds Plasmodium surface protein PfRhopH3 and that interruption of this ...
Prem Prakash, Mohammad Zeeshan, Ekta Saini, Azhar Muneer, Sachin Khurana, Bishwanath Kumar Chourasia, Arunaditya Deshmukh, Inderjeet Kaur, Surabhi Dabral, Niharika Singh, Zille Anam, Ayushi Chaurasiya, Shikha Kaushik, Pradeep Dahiya, Md. Kalamuddin, Jitendra Kumar Thakur, Asif Mohmmed, Anand Ranganathan, Pawan Malhotra   +18 more
doaj   +2 more sources

Elevated Serum Cyclophilin B Levels Are Associated with the Prevalence and Severity of Metabolic Syndrome [PDF]

Frontiers in Endocrinology, 2017
ObjectiveInflammation plays a central role in the pathogenesis of metabolic syndrome (MetS). Cyclophilin B (CypB) can be constitutively secreted in response to inflammatory stimuli and oxidative stress, participating in tissue or systemic inflammation ...
Hang Zhang, Hang Zhang, Qin Fan, Qin Fan, Hongyang Xie, Hongyang Xie, Lin Lu, Lin Lu, Rong Tao, Fang Wang, Rui Xi, Jian Hu, Qiujing Chen, Weifeng Shen, Ruiyan Zhang, Xiaoxiang Yan, Xiaoxiang Yan   +16 more
doaj   +2 more sources

Cyclophilin B control of lysine post-translational modifications of skin type I collagen. [PDF]

PLoS Genetics, 2019
Covalent intermolecular cross-linking of collagen is essential for tissue stability. Recent studies have demonstrated that cyclophilin B (CypB), an endoplasmic reticulum (ER)-resident peptidyl-prolyl cis-trans isomerase, modulates lysine (Lys ...
Masahiko Terajima, Yuki Taga, Wayne A Cabral, Ying Liu, Masako Nagasawa, Noriko Sumida, Yukako Kayashima, Prashant Chandrasekaran, Lin Han, Nobuyo Maeda, Irina Perdivara, Shunji Hattori, Joan C Marini, Mitsuo Yamauchi   +13 more
doaj   +2 more sources

Implication of the whitefly Bemisia tabaci Cyclophilin B protein in the transmission of Tomato yellow leaf curl virus [PDF]

Frontiers in Plant Science, 2016
Tomato yellow leaf curl virus (TYLCV) is a single-stranded (ssDNA) begomoviruses that causes severe damage to tomato and several other crops worldwide.
Surapathrudu Kanakala, Murad Ghanim
doaj   +2 more sources

Cyclophilin B deficiency enhances myocardial energy synthesis and protects against heart failure in preclinical models [PDF]

BMC Medicine
Background Heart failure (HF) represents the end stage of cardiovascular diseases with high mortality and limited treatment options. Cyclophilin B (CypB), known mainly as an endoplasmic reticulum chaperone, has been implicated in cardiovascular diseases.
Xiao Zong, Xierenayi Tudi, Qian Yang, Lingfang Zhuang, Roubai Pan, Qin Fan, Rong Tao   +6 more
doaj   +2 more sources

Cyclophilin A facilitates influenza B virus replication by stabilizing viral proteins

iScience, 2023
Summary: Influenza B circulates annually and causes substantial disease burden in humans. However, little is known about the infection mechanisms of influenza B virus (IBV).
Huizi Li, Wenhui Fan, Jie Min, Xiaoyuan Bai, Wenxian Yang, Heqiao Li, Yuna Zhao, Runshan Lin, Xiaojuan Jia, Wenjun Liu, Lei Sun   +10 more
doaj   +3 more sources

Plant-Mediated Silencing of the Whitefly Bemisia tabaci Cyclophilin B and Heat Shock Protein 70 Impairs Insect Development and Virus Transmission [PDF]

Frontiers in Physiology, 2019
The whitefly B. tabaci is a global pest and transmits extremely important plant viruses especially begomoviruses, that cause substantial crop losses. B.
Surapathrudu Kanakala, Svetlana Kontsedalov, Galina Lebedev, Murad Ghanim   +3 more
doaj   +2 more sources

Optimization of Cyclophilin B-Targeted Tri-vector Inhibitors for Novel MASH Treatments. [PDF]

J Med Chem
Cyclophilins have been implicated in the pathophysiology of metabolic dysfunction-associated steatohepatitis (MASH). Pharmacological inhibition of the cyclophilin B isoform has the potential to attenuate liver fibrosis in MASH, but current cyclophilin inhibitors in clinical trials lack isoform selectivity.
Kouridaki ME, Gillespie J, Robinson J, Mathie T, Bain L, McArthur D, Morrison A, Greenslade DB, Papadourakis M, Maj K, Cameron K, Turner D, Webster SP, Wear MA, Doughty-Shenton D, Hulme AN, Michel J.   +16 more
europepmc   +3 more sources

Cyclophilin B is really a major growth factor in breast milk. [PDF]

J Biol Chem, 2022
Delmas O.
europepmc   +4 more sources