Host cell species-specific effect of cyclosporine A on simian immunodeficiency virus replication
Retrovirology, 2012 Background An understanding of host cell factors that affect viral replication contributes to elucidation of the mechanism for determination of viral tropism.
Takeuchi Hiroaki +5 more
doaj +1 more source
Modulation of autocrine TNF-α-stimulated matrix metalloproteinase 9 (MMP-9) expression by mitogenactivated protein kinases in THP-1 monocytic cells [PDF]
, 2006 Matrix metalloproteinase 9 (MMP-9) is implicated in various physiological processes by its ability to degrade the extracellular matrix (ECM) and process multiple regulatory proteins. Normally, MMP-9 expression is tightly controlled in cells. Sustained or
Bogoyevitch +13 more
core +1 more source
Legionella pneumophila strain 130b evades macrophage cell death independent of the effector SidF in the absence of flagellin [PDF]
, 2017 International audienceThe human pathogen Legionella pneumophila must evade host cell death signaling to enable replication in lung macrophages and to cause disease. After bacterial growth, however, L.
Abraham, Gilu +10 more
core +4 more sources
Expression and role of cyclophilin B in stomach cancer
Genetics and Molecular Research, 2015 We elucidated the expression of ciclosporin protein B (cyclophilin B) in stomach cancer tissue and the correlation between cyclophilin B and clinicopathological parameters, and determined the effect of cyclophilin B on growth and proliferation of stomach cancer cells.
D Q, Meng, P L, Li, M, Xie
openaire +2 more sources
Role of Cyclophilin B in Prolactin Signal Transduction and Nuclear Retrotranslocation [PDF]
Molecular Endocrinology, 2000 The pleiotropic actions of PRL are necessary for mammary growth and differentiation and in vitro lymphoid proliferation. The proximal action of this ligand is mediated by its cell surface receptor via associated networks. PRL action, however, is also associated with the internalization and translocation of this hormone into the nucleus.
M A, Rycyzyn +3 more
openaire +2 more sources
When life comes to an end : lessons from microbial aging models [PDF]
, 2010 Aging of biological systems ultimately leads to death of the individual. In humans, organ failure as the result of functional impairments after stroke, cardio-vascular disease, tumor development, neurodegeneration and other diseases are certainly crucial
Osiewacz, Heinz D.
core +1 more source
The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog [PDF]
, 2014 Chronic spinal cord dysfunction occurs in dogs as a consequence of diverse aetiologies, including long-standing spinal cord compression and insidious neurodegenerative conditions. One such neurodegenerative condition is canine degenerative myelopathy (DM)
A Brodbelt +39 more
core +1 more source
Role of Cyclophilin B in Activation of Interferon Regulatory Factor-3 [PDF]
Journal of Biological Chemistry, 2005 IRF-3 is a member of the interferon regulatory factors (IRFs) and plays a principal role in the induction of interferon-beta (IFN-beta) by virus infection. Virus infection results in the phosphorylation of IRF-3 by IkappaB kinase epsilon and TANK-binding kinase 1, leading to its dimerization and association with the coactivators CREB-binding protein ...
Yoko, Obata +5 more
openaire +2 more sources
Proteomic Alterations in B Lymphocytes of Sensitized Mice in a Model of Chemical-Induced Asthma. [PDF]
PLoS ONE, 2015 The role of B-lymphocytes in chemical-induced asthma is largely unknown. Recent work demonstrated that transferring B lymphocytes from toluene diisocyanate (TDI)-sensitized mice into naïve mice, B cell KO mice and SCID mice, triggered an asthma-like ...
Steven Haenen +6 more
doaj +1 more source
Ornithine Decarboxylase mRNA is Stabilized in an mTORC1-dependent Manner in Ras-transformed Cells [PDF]
, 2012 Upon Ras activation, ODC (ornithine decarboxylase) is markedly induced, and numerous studies suggest that ODC expression is controlled by Ras effector pathways. ODC is therefore a potential target in the treatment and prevention of Ras-driven tumours. In
Albig +51 more
core +2 more sources