Targeting mutagenesis in B cells: Phosphorylation goes beyond AID association
Molecular & Cellular Oncology, 2018 The mutations induced by activation-induced cytidine deaminase (AID) trigger antibody diversification but can cause genome instability. We find that AID phosphorylation is an important determinant of “off-target” mutagenesis and identify a drug that ...
Yunxiang Mu, Kevin M. McBride
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Engineered CBEs based on Macaca fascicularis A3A with improved properties for precise genome editing
Cell ReportsSummary: Cytidine deaminase defines the properties of cytosine base editors (CBEs) for C-to-T conversion. Replacing the cytidine deaminase rat APOBEC1 (rA1) in CBEs with a human APOBEC3A (hA3A) improves CBE properties.
Chun-Yan Ren +6 more
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Az aberráns hipermutáció okozta genetikai instabilitás szerepe a B-sejtes non-Hodgkin lymphomák kialakulásában és transzformációjában = The role of genetic instability caused by aberrant hypermutation in the development and transformation of B-cell non-Hodgkin lymphomas [PDF]
, 2008 A kutatás eredményeként bizonyítottuk, hogy a krónikus lymphocytás leukémia (CLL) és a follicularis lymphoma (FL) kifejezett malignitású lymphomába történő transzformációjában, valamint a mediastinalis nagy B-sejtes lymphoma (MLBL) kialakulásában ...
Bognár, Ágnes +5 more
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VH replacement in rearranged immunoglobulin genes [PDF]
, 2005 Examples suggesting that all or part of the V<sub>H</sub> segment of a rearranged V<sub>H</sub>DJ<sub>H</sub> may be replaced by all or part of another V<sub>H</sub> have been appearing since the 1980s ...
Brokaw JL +21 more
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Maize haplotype with a
BMC Genetics, 2006 Background Genetic maps are based on recombination of orthologous gene sequences between different strains of the same species. Therefore, it was unexpected to find extensive non-collinearity of genes between different inbred strains of maize ...
Messing Joachim, Xu Jian-Hong
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Naturally occurring mutation affecting the MyD88-binding site of TNFRSF13B impairs triggering of class switch recombination [PDF]
, 2013 Mutations in the transmembrane activator and calcium-modulating cyclophilin ligand interactor (TACI) were previously found to be associated with hypogammaglobulinemia in humans.
Almejún, María Belén +7 more
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AIDing Chromatin and Transcription-Coupled Orchestration of Immunoglobulin Class-Switch Recombination [PDF]
, 2014 Secondary diversification of the antibody repertoire upon antigenic challenge, in the form of immunoglobulin heavy chain (IgH) class-switch recombination (CSR) endows mature, naïve B cells in peripheral lymphoid organs with a limitless ability to mount ...
Bharat Vaidyanathan +3 more
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Effects of APOBEC3G's Cytidine Deaminase Activity on Retroviral Evolution
, 2021 Mary-Benedicta Obikili
openalex +2 more sources
APOBEC3G encapsidation into HIV-1 virions: which RNA is it?
Retrovirology, 2008 APOBEC3G is a cytidine deaminase with potent antiviral activity. The protein deaminates single-stranded DNA but is known to bind cellular and viral RNAs.
Khan Mohammad A, Strebel Klaus
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Elevated numbers of PD-L1 expressing B cells are associated with the development of AIDS-NHL. [PDF]
, 2019 The risk for non-Hodgkin lymphoma (NHL) is markedly increased in persons living with human immunodeficiency virus (HIV) infection, and remains elevated in those on anti-retroviral therapy (cART).
Conti, David V +5 more
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