Results 111 to 120 of about 30,295 (249)

Data from Target Sequence Accessibility Limits Activation-Induced Cytidine Deaminase Activity in Primary Mediastinal B-Cell Lymphoma

, 2023
Sergey Popov, Gerhard Moldenhauer, Beate Wotschke, Silke Brüderlein, Thomas F.E. Barth, Karola Dorsch, Olga Ritz, Peter Mӧller, Frank Leithäuser   +8 more
openalex   +1 more source

Improving the DNA specificity and applicability of base editing through protein engineering and protein delivery

Nature Communications, 2017
Third-generation base editors consist of a catalytically disabled Cas9 fused to a cytidine deaminase and a base excision repair inhibitor, enabling efficient, precise editing of individual base pairs in DNA.
Holly A. Rees, Alexis C. Komor, Wei-Hsi Yeh, Joana Caetano-Lopes, Matthew Warman, Albert S. B. Edge, David R. Liu   +6 more
doaj   +1 more source

Salvage enzymes in nucleotide biosynthesis [PDF]

, 2007
Balanced pools of deoxyribonucleoside triphosphates (dNTPs), the building blocks of DNA, and ribonucleoside triphosphates (NTPs), the precursors of RNA, are crucial for a controlled cell proliferation.
Kosinska, Urszula
core  

Identification of two epitypes of IGHV unmutated chronic lymphocytic leukemia with distinct B‐cell‐related epigenetic imprinting and genetic alterations

HemaSphere, Volume 10, Issue 1, January 2026.
Stella Charalampopoulou, Silvia Ramos‐Campoy, Marti Duran‐Ferrer, Anna Puiggros, Joanna Kamaso, Florence Nguyen‐Khac, Gian Matteo Rigolin, Antonio Cuneo, Rosa Collado, Rocío García‐Serra, Claudia Haferlach, Margarita Ortega, Pau Abrisqueta, Francesc Bosch, Thorsten Zenz, María Laura Blanco, Rocío Salgado, Mª Dolores García‐Malo, Eva Gimeno, Armando Lopez‐Guillermo, Elias Campo, Laurence Etter, Jacqueline Schoumans, Blanca Espinet, Jose I. Martin‐Subero   +24 more
wiley   +1 more source

Activation-induced cytidine deaminase deficiency causes organ-specific autoimmune disease.

PLoS ONE, 2008
Activation-induced cytidine deaminase (AID) expressed by germinal center B cells is a central regulator of somatic hypermutation (SHM) and class switch recombination (CSR).
Koji Hase, Daisuke Takahashi, Masashi Ebisawa, Sayaka Kawano, Kikuji Itoh, Hiroshi Ohno   +5 more
doaj   +1 more source

Highly Efficient Base Editing in Viral Genome Based on Bacterial Artificial Chromosome Using a Cas9-Cytidine Deaminase Fused Protein [PDF]

, 2019
Ke Zheng, Fangfang Jiang, Le Su, Xin Wang, Yuxin Chen, Huanchun Chen, Zheng‐Fei Liu   +6 more
openalex   +1 more source

The SV40 virus enhancer functions as a somatic hypermutation-targeting element with potential tumorigenic activity

Tumour Virus Research
Simian virus 40 (SV40) is a monkey virus with tumorigenic potential in rodents and is associated with several types of human cancers, including lymphomas.
Filip Šenigl, Anni I. Soikkeli, Salomé Prost, David G. Schatz, Martina Slavková, Jiří Hejnar, Jukka Alinikula   +6 more
doaj   +1 more source

Determinants of Specificity for the Trypanosoma brucei A to I tRNA Editing Deaminase [PDF]

, 2008
Trypanosomatids are responsible for causing illness and death among millions of humans and animals worldwide. Two main genera of these unicellular flagellated parasites are Trypanosoma, which cause African sleeping sickness and Chagas disease, and ...
Tseng, Ashlie
core  

A Portable Hot Spot Recognition Loop Transfers Sequence Preferences from APOBEC Family Members to Activation-induced Cytidine Deaminase [PDF]

, 2009
Rahul M. Kohli, Shaun R. Abrams, Kiran S. Gajula, Robert W. Maul, Patricia J. Gearhart, James T. Stivers   +5 more
openalex   +1 more source

Construction of Mycobacterium tuberculosis cdd knockout and evaluation of invasion and growth in macrophages

Memorias do Instituto Oswaldo Cruz
Cytidine deaminase (MtCDA), encoded by cdd gene (Rv3315c), is the only enzyme identified in nucleotide biosynthesis pathway of Mycobacterium tuberculosis that is able to recycle cytidine and deoxycytidine. An M.
Anne Drumond Villela, Valnês S Rodrigues-Junior, Antônio Frederico Michel Pinto, Virgínia Carla de Almeida Falcão, Zilpa Adriana Sánchez-Quitian, Paula Eichler, Cristiano Valim Bizarro, Luiz Augusto Basso, Diógenes Santiago Santos   +8 more
doaj   +1 more source