Results 121 to 130 of about 30,295 (249)

Intratumoral bacteria may elicit chemoresistance by metabolizing anticancer agents

Molecular & Cellular Oncology, 2018
We recently reported that bacteria can be found within pancreatic ductal adenocarcinoma (PDAC) tumors. Some of these bacteria can metabolize and thereby inactivate the nucleoside analog gemcitabine.
Leore T. Geller, Ravid Straussman
doaj   +1 more source

Supplementary Figures and Tables 1-3 from Activation-Induced Cytidine Deaminase Accelerates Clonal Evolution in <i>BCR-ABL1</i>–Driven B-Cell Lineage Acute Lymphoblastic Leukemia

, 2023
Tanja A. Grüber, Mi Sook Chang, Richard Sposto, Markus Müschen   +3 more
openalex   +2 more sources

5'-nucleotidases, nucleosides and their distribution in the brain: pathological and therapeutic implications [PDF]

, 2013
Elements of the nucleoside system (nucleoside levels, 5'-nucleotidases (5'NTs) and other nucleoside metabolic enzymes, nucleoside transporters and nucleoside receptors) are unevenly distributed in the brain, suggesting that nucleosides have region ...
Dobolyi, Árpád, Juhász, Gábor, Kovács, Zsolt, Kékesi, Katalin A.   +3 more
core  

Supplementary Table S1 from Activation-Induced Cytidine Deaminase Contributes to Pancreatic Tumorigenesis by Inducing Tumor-Related Gene Mutations

, 2023
Yugo Sawai, Yuzo Kodama, Takahiro Shimizu, Yuji Ota, Takahisa Maruno, Yuji Eso, Akira Kurita, Masahiro Shiokawa, Yoshihisa Tsuji, Norimitsu Uza, Yuko Matsumoto, Toshihiko Masui, Shinji Üemoto, Hiroyuki Marusawa, Tsutomu Chiba   +14 more
openalex   +1 more source

B cell distribution and activation-induced cytidine deaminase expression in rheumatoid synovitis: clinical and bio-molecular correlates [PDF]

, 2011
Serena Bugatti, Antonio Manzo, B. Vitolo, Chiara Fusetti, F. Humby, Roberto Caporali, C. Pitzalis, Carlomaurizio Montecucco   +7 more
openalex   +1 more source

A circuitous route for in vitro multi-enzyme cascade production of cytidine triphosphate to overcome the thermodynamic bottleneck

Bioresources and Bioprocessing
Cytidine triphosphate (CTP), as a substance involved in the metabolism of phospholipids, proteins and nucleic acids, has precise drug effects and is a direct precursor for the synthesis of drugs such as citicoline.
Zonglin Li, Yahui Zhong, Zhoulei Qing, Zhimin Li   +3 more
doaj   +1 more source

Association of Cytidine Deaminase Polymorphism with Capecitabine Effectiveness in Breast Cancer Patients. [PDF]

Asian Pac J Cancer Prev, 2023
Aldeen Majeed AA, Salih Sahib A, Shakir Mahmood H, Kadhim Mohsin K, Fadhl Abbas R.   +4 more
europepmc   +1 more source

C-terminal region of activation-induced cytidine deaminase (AID) is required for efficient class switch recombination and gene conversion [PDF]

, 2014
Somayeh Sabouri, Maki Kobayashi, Nasim A. Begum, Jianliang Xu, Kouji Hirota, Tasuku Honjo   +5 more
openalex   +1 more source

Molecular mechanism for regulating APOBEC3G DNA editing function by the non-catalytic domain

Nature Communications
APOBEC3G, part of the AID/APOBEC cytidine deaminase family, is crucial for antiviral immunity. It has two zinc-coordinated cytidine-deaminase domains.
Hanjing Yang, Josue Pacheco, Kyumin Kim, Ayub Bokani, Fumiaki Ito, Diako Ebrahimi, Xiaojiang S. Chen   +6 more
doaj   +1 more source

De novo protein synthesis is required for activation-induced cytidine deaminase-dependent DNA cleavage in immunoglobulin class switch recombination

, 2004
Nasim A. Begum, Kazuo Kinoshita, Masamichi Muramatsu, Hitoshi Nagaoka, Reiko Shinkura, Tasuku Honjo   +5 more
openalex   +1 more source