Deaminase-independent inhibition of parvoviruses by the APOBEC3A cytidine deaminase.
PLoS Pathogens, 2009 The APOBEC3 proteins form a multigene family of cytidine deaminases with inhibitory activity against viruses and retrotransposons. In contrast to APOBEC3G (A3G), APOBEC3A (A3A) has no effect on lentiviruses but dramatically inhibits replication of the ...
Iñigo Narvaiza +7 more
doaj +4 more sources
Human APOBEC1 cytidine deaminase edits HBV DNA [PDF]
Retrovirology, 2009 Retroviruses, hepadnaviruses, and some other retroelements are vulnerable to editing by single stranded DNA cytidine deaminases. Of the eleven human genes encoding such enzymes, eight have demonstrable enzymatic activity.
Wain-Hobson Simon +5 more
doaj +3 more sources
Cytidine deaminase can deaminate fused pyrimidine ribonucleosides. [PDF]
Org Biomol Chem, 2021 Cytidine deaminase effectively deaminates three emissive fused cytidine analogues and the reactions can be monitored in real time by fluorescence.
Ludford PT, Li Y, Yang S, Tor Y.
europepmc +5 more sources
A genome-wide identification and analysis of the DYW-deaminase genes in the pentatricopeptide repeat gene family in cotton (Gossypium spp.). [PDF]
PLoS ONE, 2017 The RNA editing occurring in plant organellar genomes mainly involves the change of cytidine to uridine. This process involves a deamination reaction, with cytidine deaminase as the catalyst.
Bingbing Zhang +11 more
doaj +1 more source
Prospectively defined patterns of APOBEC3A mutagenesis are prevalent in human cancers
Cell Reports, 2022 Summary: Mutational signatures defined by single base substitution (SBS) patterns in cancer have elucidated potential mutagenic processes that contribute to malignancy.
Rachel A. DeWeerd +7 more
doaj +1 more source
Nature Communications, 2023 APOBEC’s are a family of cytidine deaminases that induce mutations in viruses to inhibit their replication and maintain cell integrity. Here, Manjunath et al show that APOBEC3B also inhibits viral replication by stimulating the innate immune sensor ...
Lavanya Manjunath +12 more
doaj +1 more source
Precise base editing with CC context-specificity using engineered human APOBEC3G-nCas9 fusions
BMC Biology, 2020 Background Cytidine base editors (CBEs), composed of a cytidine deaminase fused to Cas9 nickase (nCas9), enable efficient C-to-T conversion in various organisms. However, current base editors can induce unwanted bystander C-to-T conversions when multiple
Zhiquan Liu +7 more
doaj +1 more source
Single-stranded DNA binding proteins influence APOBEC3A substrate preference
Scientific Reports, 2021 The cytidine deaminase, APOBEC3A (A3A), is a prominent source of mutations in multiple cancer types. These APOBEC-signature mutations are non-uniformly distributed across cancer genomes, associating with single-stranded (ss) DNA formed during DNA ...
Amber L. Brown +5 more
doaj +1 more source
Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system. [PDF]
, 2017 Precise genetic modifications in model animals are essential for biomedical research. Here, we report a programmable "base editing" system to induce precise base conversion with high efficiency in zebrafish. Using cytidine deaminase fused to Cas9 nickase,
Bai, Haipeng +7 more
core +1 more source
Activation-induced deoxycytidine deaminase (AID) co-transcriptional scanning at single-molecule resolution [PDF]
, 2015 Activation-induced deoxycytidine deaminase (AID) generates antibody diversity in B cells by initiating somatic hypermutation (SHM) and class-switch recombination (CSR) during transcription of immunoglobulin variable (IgV) and switch region (IgS) DNA ...
Bertram, JG +7 more
core +1 more source