In vitro Assay for Cytidine Deaminase Activity of APOBEC3 Protein
Bio-Protocol, 2014 Cytidine deaminases are enzymes that catalyze the removal of an amino group from cytidine, forming uridine. APOBEC3 (ApolipoproteinB mRNA editing enzyme, catalytic polypeptide like) proteins are cytidine deaminases that deaminate cytidines in ...
Smita Nair, Smita Nair
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Multiple gene substitution by Target-AID base-editing technology in tomato
Scientific Reports, 2020 The use of Target activation-induced cytidine deaminase (Target-AID) base-editing technology with the CRISPR-Cas 9 system fused with activation-induced cytidine deaminase (AID) resulted in the substitution of a cytidine with a thymine.
Johan Hunziker +5 more
doaj +1 more source
Adenosine to inosine editing by ADAR2 requires formation of a ternary complex on the GluR-B R/G site [PDF]
, 2002 RNA editing by members of the ADAR (adenosine deaminase that acts on RNA) enzyme family involves hydrolytic deamination of adenosine to inosine within the context of a double-stranded pre-mRNA substrate.
Collins, Cynthia H. +2 more
core +1 more source
The antilymphocytic activity of brequinar sodium and its potentiation by cytidine: Effects on lymphocyte proliferation and cytokine production [PDF]
, 1993 Based on its capacity to inhibit de novo pyrimidine biosynthesis by blocking dihydroorotate dehydrogenase activity, the antitumor agent brequinar sodium (BQR) has emerged as a new immunosuppressive agent.
Lemster, B +4 more
core +1 more source
The Immunoglobulins of Cold-Blooded Vertebrates [PDF]
, 2014 Peer reviewedPublisher ...
Chen +22 more
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Cytidine deaminases: AIDing DNA demethylation? [PDF]
Genes & Development, 2010 The presence of 5-methylcytosine (5-mC) in DNA is a vital epigenetic mark in vertebrates. While the enzymes responsible for methylating DNA in vertebrates have been identified, the means by which this mark can be removed are still unclear. Recently, it has been shown that activation-induced cytidine deaminase (AID) contributes to the demethylation of ...
Eric L, Fritz, F Nina, Papavasiliou
openaire +2 more sources
Mutant loxP vectors for selectable marker recycle and conditional knock-outs [PDF]
, 2001 BACKGROUND: Gene disruption by targeted integration of transfected constructs becomes increasingly popular for studies of gene function. The chicken B cell line DT40 has been widely used as a model for gene knock-outs due to its high targeted integration
Arakawa, Hiroshi +2 more
core +3 more sources
Characterization of Ovine A3Z1 Restriction Properties against Small Ruminant Lentiviruses (SRLVs) [PDF]
, 2017 Intrinsic factors of the innate immune system include the apolipoprotein B editing enzyme catalytic polypeptide-like 3 (APOBEC3) protein family. APOBEC3 inhibits replication of different virus families by cytosine deamination of viral DNA and a not fully
Amorena, Beatriz +7 more
core +2 more sources
Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID
Nature Communications, 2018 CRISPR-guided cytidine deaminases, including BE3 (Base Editor 3) and Target-AID (activation-induced cytidine deaminase), can covert C:G base pairs to T:A at target site.
Hiroki Sasaguri +9 more
doaj +1 more source
Nature Communications, 2021 The cytidine deaminase APOBEC3A is a main source of mutagenesis in many types of cancer. Here the authors reveal that transient up-regulation of APOBEC3A and other pro-inflammatory genes can occur due to viral infection and genotoxic stress via multiple ...
Sunwoo Oh +12 more
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