Results 41 to 50 of about 30,295 (249)

Resistance of Cyclocytidine to Cytidine Deaminase

Chemical and Pharmaceutical Bulletin, 1973
Deamination of cytidine derivatives especially of cyclocytidine by mouse kidney cytidine deaminase was examined. Cyclocytidine was not deaminated at either pH6.5 or pH7.3 by the enzyme. Furthermore, cyclocytidine did not inhibit the deamination of aracytidine and ([I]/[S])0.5 value for cyclocytidine was over 100.
A, Hoshi, M, Iigo, M, Saneyoshi, K, Kuretani   +3 more
openaire   +3 more sources

DNA (Cytosine-C5) methyltransferase inhibition by oligodeoxyribonucleotides containing 2-(1H)-pyrimidinone (zebularine aglycon) at the enzymatic target site [PDF]

, 2009
20 pages, 7 figures, 1 table.-- PMID: 19467223 [PubMed].-- PMCID: PMC2756644.-- NIHMSID: NIHMS130041.-- Printed version published Sep 15, 2009.Aberrant cytosine methylation in promoter regions leads to gene silencing associated with cancer progression. A
Van Bemmel, Dana M., Brank, Adam S., Eritja Casadellà, Ramón, Márquez, Víctor E., Christman, Judith K.   +4 more
core   +1 more source

Human placenta cytidine deaminase: a zinc metalloprotein [PDF]

IUBMB Life, 1997
AbstractCytidine deaminase, a tetrameric enzyme purified from human placenta, was shown to contain a single atom of tightly bound zinc per subunit by Inductively Coupled Plasma Optical Emission Spectrometry analysis. The metal appears to be involved in catalysis, as suggested by the inhibition exerted by 1,10‐phenanthroline and dipicolinic acid.
VINCENZETTI, Silvia, A. CAMBI, BALDUCCI, Enrico, NATALINI, Paolo, VOLPINI, Rosaria, VITA, Alberto   +5 more
openaire   +3 more sources

Contribution of Cytidine Deaminase to Thymidylate Biosynthesis in Trypanosoma brucei: Intracellular Localization and Properties of the Enzyme

mSphere, 2019
Cytidine deaminase (CDA) is a pyrimidine salvage enzyme that catalyzes cytidine and deoxycytidine hydrolytic deamination to yield uridine and deoxyuridine.
Ana Moro-Bulnes, Víctor M. Castillo-Acosta, Maria Valente, Juana Carrero-Lérida, Guiomar Pérez-Moreno, Luis Miguel Ruiz-Pérez, Dolores González-Pacanowska   +6 more
doaj   +1 more source

Activation-Induced Cytidine Deaminase Does Not Impact Murine Meiotic Recombination [PDF]

, 2013
Activation-Induced Cytidine Deaminase (AID) was first described as the triggering enzyme of the B-cell-specific reactions that edit the immunoglobulin genes, namely somatic hypermutation, gene conversion and class switch recombination.
Barreto, V. M., Cortesao, C. S., Freitas, R. F.   +2 more
core   +1 more source

Structural features of antiviral DNA cytidine deaminases [PDF]

bchm, 2013
Abstract The APOBEC3 (A3) family of cytidine deaminases plays a vital role for innate defense against retroviruses. Lentiviruses such as HIV-1 evolved the Vif protein that triggers A3 protein degradation. There are seven A3 proteins, A3A-A3H, found in humans.
Vasudevan, Ananda Ayyappan Jaguva, Smits, Sander H. J., Höppner, Astrid, Häussinger, Dieter, Münk, Carsten, König, Bernd   +5 more
openaire   +3 more sources

Increasing fidelity and efficiency by modifying cytidine base-editing systems in rice

Crop Journal, 2020
The efficiency of plant cytidine base-editing systems is limited, and unwanted mutations frequently occur in transgenic plants. We increased the cytidine editing frequency and fidelity of the plant base editor 3 (BE3) and targeted activation-induced ...
Ruiying Qin, Shengxiang Liao, Juan Li, Hao Li, Xiaoshuang Liu, Jianbo Yang, Pengcheng Wei   +6 more
doaj   +1 more source

Aberrant Activation-Induced Cytidine Deaminase Gene Expression Links BCR/ABL1-Negative Classical Myeloproliferative Neoplasms

Haseki Tıp Bülteni, 2022
Aim:Activation-induced cytidine deaminase (AID) has been associated with tumor initiation and development because of its ability to generate DNA damage and somatic mutations that cause genomic instability. This study aimed to investigate the relationship
Hasan Dermenci, Aynur Daglar Aday, Aysegul Basak Akadam Teker, Veysel Sabri Hancer, Metin Yusuf Gelmez, Meliha Nalcaci, Akif Selim Yavuz   +6 more
doaj   +1 more source

DNA demethylation pathways: Additional players and regulators. [PDF]

, 2017
DNA demethylation can occur passively by "dilution" of methylation marks by DNA replication, or actively and independently of DNA replication. Direct conversion of 5-methylcytosine (5mC) to cytosine (C), as originally proposed, does not occur.
Abdouni, An, Arakawa, Barreto, Bellon, Bhutani, Bhutani, Blaschke, Boorstein, Bourc'his, Bransteitter, Brown, Buganim, Chakraborty, Chen, Chen, Chen, Chowdhury, Chung, Cortazar, Cortellino, Costa, Dai, Dai, Dang, Dawlaty, Dawlaty, Dawlaty, Delhommeau, Doege, Dominguez, Engel, Fortini, Foshay, Fousteri, Franchini, Fritz, Fritz, Gao, Ge, Gehring, Gjini, Grin, Gu, Guo, Guo, Habib, Hajkova, Hashimoto, Hashimoto, Hashimoto, Hashimoto, Hata, Hata, He, Henson, Hildrestrand, Hogenbirk, Hollander, Hon, Hu, Hu, Iiams, Inoue, Iqbal, Ito, Iyer, Jin, Jin, Jiricny, Jones, Kagiwada, Kaneda, Kellinger, Ko, Kosmider, Kou, Kriaucionis, Krokan, Kumar, Langemeijer, Larijani, Laukka, Lenz, Li, Li, Li, Li, Liu, Liutkeviciute, Lorsbach, Lu, Ma, Maiti, Maiti, Marusawa, Mayer, Moran-Crusio, Muller, Muramatsu, Muramatsu, Nabel, Nakanishi, Nemec, Niehrs, Nilsen, Ohno, Okano, Ooi, Pais, Pastor, Perez, Petersen-Mahrt, Pfaffeneder, Pollard, Popp, Rai, Raiber, Ramiro, Rangam, Revy, Rommel, Rusmintratip, Sabag, Sajadian, Santos, Schiesser, Schiesser, Schmitz, Schomacher, Sciacovelli, Sejersted, Shen, Shen, Shibutani, Shimamoto, Shimoda, Silverman, Spruijt, Stier, Szulik, Tahiliani, Tamura, Tan, Vartanian, Verdine, Wagner, Wang, Weber, Wijesinghe, Wojciechowski, Wu, Xiao, Xu, Xu, Xu, Xue, Yamazaki, Yin, Young, Zanotti, Zhao, Zhu   +162 more
core   +1 more source

Epigenetic targeting of activation-induced cytidine deaminase [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Activation-induced cytidine deaminase (AID) is a DNA modifying enzyme crucial for the generation of efficacious antibodies. AID also promiscuously introduces DNA lesions at cancer genes, leading to their chromosome translocation and lymphoma. However, how AID is recruited to these off targets is not well understood.
Qiao, Wang, Thiago, Oliveira, Mila, Jankovic, Israel T, Silva, Ofir, Hakim, Kaihui, Yao, Anna, Gazumyan, Christian T, Mayer, Rushad, Pavri, Rafael, Casellas, Michel C, Nussenzweig, Davide F, Robbiani   +11 more
openaire   +2 more sources