Results 61 to 70 of about 30,295 (249)
Endoglin Is Essential for the Maintenance of Self-Renewal and Chemoresistance in Renal Cancer Stem Cells. [PDF]
, 2017 Renal cell carcinoma (RCC) is a deadly malignancy due to its tendency to metastasize and resistance to chemotherapy. Stem-like tumor cells often confer these aggressive behaviors.
Dai, Jin +10 more
core +3 more sources
Advanced NanoBiomed Research, EarlyView.This review explains how biomaterials and nanoparticles can be used to induce or modulate tertiary lymphoid structures (TLSs), which are ectopic immune hubs that form in nonlymphoid tissues during chronic disease and cancer. By comparing different methods, the article highlights design principles for modeling TLSs or recapitulating specific TLS ...
Shaza Karaman, Mei ElGindi, Jeremy Teo
wiley +1 more source
Anatomical Distribution of Nucleoside System in the Human Brain and Implications for Therapy [PDF]
, 2013 Nucleosides have a wide range of physiological and pathophysiological roles in the human brain as modulators of a variety of neural functions. For example, adenosine, inosine, guanosine, and uridine participate in the mechanisms underlying memory ...
Dobolyi, Árpád, Kovács, Zsolt
core +1 more source
A Novel Cytidine Deaminase Affects Antibody Diversity [PDF]
Cell, 2000 It has not been determined whether AID normally acts as a DNA or RNA deaminase. In vitro, deamination of monomeric deoxycytidine was efficient (Muramatsu et al. 1999xMuramatsu, M, Sankaranand, V, Anant, S, Sugai, M, Kinoshita, K, Davidson, N, and Honjo, T. J. Biol. Chem.
Longacre, Angelika, Storb, Ursula
openaire +2 more sources
Arthritis &Rheumatology, EarlyView.Sjögren disease (SjD) is a common systemic autoimmune disorder characterized by inflammation of the exocrine glands, resulting in dryness. Patients frequently exhibit extraglandular manifestations affecting various organ systems. To date, there are no US Food and Drug Administration (FDA)‐approved disease‐modifying therapies for SjD. In this review, we
Rachael A. Gordon, Sara S. McCoy
wiley +1 more source
Control of Human Anelloviruses by Cytosine to Uracil Genome Editing
mSphere, 2022 Anelloviruses are the most common viruses infecting humans. Every human carries a nonpathogenic personal anellovirus virome (anellome), yet it is unknown which mechanisms contribute to its stability.
Anne L. Timmerman +4 more
doaj +1 more source
DNA replication stress mediates APOBEC3 family mutagenesis in breast cancer [PDF]
, 2016 BACKGROUND: The APOBEC3 family of cytidine deaminases mutate the cancer genome in a range of cancer types. Although many studies have documented the downstream effects of APOBEC3 activity through next-generation sequencing, less is known about their ...
Bartek, J +16 more
core +8 more sources
Cytidine Deaminase Activity Drives Cytotoxicity of Modified Cytidines [PDF]
Cancer Discovery, 2015 Abstract Cytidine deaminase (CDA) overexpression confers susceptibility to epigenetically modified cytidines.
openaire +1 more source
Restriction of Foamy Viruses by APOBEC Cytidine Deaminases [PDF]
Journal of Virology, 2006 ABSTRACT Foamy viruses (FVs) are nonpathogenic retroviruses infecting many species of mammals, notably primates, cattle, and cats. We have examined whether members of the apolipoprotein B-editing catalytic polypeptide-like subunit (APOBEC) family of antiviral cytidine deaminases restrict replication of simian FV.
Delebecque, Frédéric +9 more
openaire +4 more sources
CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling
Med Research, EarlyView.CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li +8 more
wiley +1 more source