Results 181 to 190 of about 2,499,952 (347)

Tetrahydrocurcumin Ameliorates Homocysteinylated Cytochrome-c Mediated Autophagy in Hyperhomocysteinemia Mice after Cerebral Ischemia

Journal of Molecular Neuroscience, 2012
N. Tyagi, Natia Qipshidze, C. Munjal, Jonathan C. Vacek, Naira S. Metreveli, S. Givvimani, S. Tyagi   +6 more
semanticscholar   +1 more source

A Single‐Molecule Pleuripotent Scaffold for Combinational Therapy of Alzheimer's Disease via Intranasal Administration

Advanced Science, EarlyView.
Herein, guanidinium‐modified calix[5]arene (GC5AY) is developed featuring small size, positive charge, and desirable amphiphilicity, that can efficiently traverse the nasal mucosal barrier for brain drug delivery. Additionally, possessing inherent therapeutic functions, GC5AY can thus serve as a single‐molecule pleuripotent scaffold for multi‐target ...
Jian‐Mei Gao, Wen‐Bo Li, Na‐Na Chen, Yang Yi, Ze‐Han Wang, Xian Chen, Yang‐Yang Zhao, Ze‐Li Yuan, Jie Gao, Yu‐Chen Pan, Dong‐Sheng Guo, Qi‐Hai Gong   +11 more
wiley   +1 more source

Hepatocellular Early Apoptosis Associated with HES 130/0.4 Administration for Volume Replacement in Pigs After Severe Bleeding. [PDF]

Vet Sci
Vala H, Faustino-Rocha AI, Cruz R, Venâncio C, Silva A, Mesquita JR, Ortiz AL, Ferreira DA.   +7 more
europepmc   +1 more source

MacA is a second cytochrome c peroxidase of Geobacter sulfurreducens.

Biochemistry, 2012
J. Seidel, M. Hoffmann, Katie E Ellis, A. Seidel, T. Spatzal, S. Gerhardt, S. Elliott, O. Einsle   +7 more
semanticscholar   +1 more source

Nortriptyline Inhibits Lysosomal Exocytosis‐Mediated SASP During Gastric Cancer Progression via Targeting HOXA1‐PITX2 Phase Separation

Advanced Science, EarlyView.
This study identifies that HOXA1 facilitates transcriptional activity of PITX2 in liquid condensates, resulting in up‐regulation of MCOLN1 and RAB3A followed by lysosomal exocytosis of LGALS1 and IGFBP7 from senescent cells, thus activating AKT signaling and EMT.
Yi Zhou, Chunhui Yang, Xinyue Li, Xiaojing Wang, Wanju Jiao, Xiaolin Wang, Jiaying Qu, Bosen Zhao, Shunchen Zhou, Qiangsong Tong, Liduan Zheng   +10 more
wiley   +1 more source

Molecular phylogeny of some Carangid species from the Egyptian Red Sea using cytochrome c oxidase subunit I (<i>COI</i>) and small (<i>12S rRNA</i>) mitochondrial rRNA genes. [PDF]

Open Vet J
Allam M, Eisa SGAA, Almaaty AHA, Hassan MK.   +3 more
europepmc   +1 more source

An Engineered Probiotic Consortium Based on Quorum‐Sensing for Colorectal Cancer Immunotherapy

Advanced Science, EarlyView.
This work develops an engineered probiotic consortium sensing pH, hypoxia, and lactate in the tumor microenvironment. It releases a lactate‐depleting enzyme (LdhA) and a PD‐L1 nanobody. In humanized mouse models (MC38 and HT‐29 tumors), it achieves durable oscillations, suppresses tumors, activates CD8+, CD4+, IFN‐γ+ T cells, and reduces Foxp3 ...
Yufei Guo, Mengxue Gao, Lina Wang, Haibin Yuan, Jianan Yin, Jiahao Wu, Xinran Gao, Zhixin Zhu, Yan Zhang, Zichen Wang, He Huang, Guangbo Kang   +11 more
wiley   +1 more source

Electron shuttling promotes denitrification and mitigates nitrous oxide emissions in lakes. [PDF]

Nat Commun
Song K, Xiao Y, Wang Y, Deng M, Zhou S, Huang Y, Yeerken S, Li L, Wu F.   +8 more
europepmc   +1 more source

Interconversions between RNS Revealed by Transient Voltammetry with Porphyrin‐Modified Carbon Nanopipettes in Single Living Cells

Advanced Science, EarlyView.
By using porphyrin modified conductive nanopipettes, transient voltammetry can be directly applied to reveal the dynamic and complex electrochemical reactions between the reactive nitrogen species inside the single living cells. Abstract Reactive nitrogen species (RNS) play crucial roles in cellular signaling, but their quantification is very ...
Hongli Cao, Dehui Yu, Yingjie Zhao, Xiaoyue Shen, Rujia Liu, Dengchao Wang   +5 more
wiley   +1 more source

All-trans-retinal as a modulator of metabolic and mitochondrial signatures in non-tumorigenic and malignant breast cells: a Raman-based approach. [PDF]

Mikrochim Acta
Jarczewska K, Kopeć M, Surmacki JM.
europepmc   +1 more source