Results 181 to 190 of about 242,283 (275)

Artificial intelligence modelling of tyrosine kinase inhibitors at risk of malabsorption and bioavailability‐enhancing strategies

British Journal of Clinical Pharmacology, EarlyView.
Aims The study aims to predict and improve the absorption of tyrosine kinase inhibitors (TKIs) in patients with malabsorption issues, particularly those who have undergone bariatric surgery or are using proton‐pump inhibitors. The research involves 2 main components: the development of an artificial intelligence (AI) model to identify TKIs that are ...
Daan W. Huntjens, Olivier J. M. Béquignon, Stefanie D. Krens, Mark Löwenberg, Martine E. D. Chamuleau, Remco J. Molenaar, Anita M. G. Kramers, Marianne A. Kuijvenhoven, Imke H. Bartelink   +8 more
wiley   +1 more source

<i>miR-19-3p</i>/GRSF1/COX1 axis attenuates early brain injury via maintaining mitochondrial function after subarachnoid haemorrhage. [PDF]

Stroke Vasc Neurol
Gao G, Sun X, Xu J, Yu J, Wang Y.
europepmc   +1 more source

Oxidative Phosphorylation in Uncoupled Mitochondria

BioEssays, EarlyView.
Brown adipose tissue (BAT) mediates non‐shivering thermogenesis (NST) through activation of uncoupling protein 1 (UCP1). Due to the uncoupled nature of BAT, oxidative phosphorylation is an underappreciated contributor to NST. Here, we discuss the implications of Inhibitory Factor 1 modulation, an endogenous inhibitor of ATP synthase, for BAT physiology.
Henver S. Brunetta, Marcelo A. Mori, Alexander Bartelt   +2 more
wiley   +1 more source

Toxic Effects of p-Chloroaniline on Cells of Fungus <i>Isaria fumosorosea</i> SP535 and the Role of Cytochrome P450. [PDF]

Toxics
Huang S, Gao J, Zhou L, Gao L, Song M, Zeng Q.   +5 more
europepmc   +1 more source

Complex Interplay of Metabolic Substrates, Points of Entry into the Mitochondrial Electron Chain, and ROS Generation

BioEssays, EarlyView.
Recently, Singh et al. studied the influence of reactive oxygen species (ROS) formation by the ETC on mitochondrial morphology in baker's yeast. Their findings highlight evolutionary constraints, important trade‐offs using different metabolic substrates, and connections with points of entry into the ETC, ROS production, the FADH2/NADH ratio concept ...
Dave Speijer
wiley   +1 more source

Mitochondrial DNA data allow distinguishing the subpopulations in the widespread Demoiselle crane (Anthropoides virgo). [PDF]

Vavilovskii Zhurnal Genet Selektsii
Mudrik ЕА, Ilyashenko ЕI, Kazimirov PA, Kondrakova KD, Archimaeva TP, Bazarov LD, Goroshko ОА, Dorzhiev TZ, Kuksin AN, Postelnykh КА, Shurkina VV, Ilyashenko VY, Shatokhina AV, Politov DV.   +13 more
europepmc   +1 more source

Exploring Multi‐Organ Crosstalk via the TissUse HUMIMIC Chip System: Lessons Learnt So Far

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Three‐dimensional (3D) in vitro cell culture models have revolutionized biomedical research by mimicking the complex 3D in vivo environment in the human body. Different types of 3D models have been established, including heterotypic systems such as, organ‐on‐a‐chips which have been further developed into multiorgan‐on‐chip systems that ...
Filsan Ahmed Abokor, Safiya Al Yazeedi, Janaeya Zuri Baher, Chung Cheung, Don D. Sin, Emmanuel Twumasi Osei   +5 more
wiley   +1 more source

Flexibility and Hydration of the Q_o Site Determine Multiple Pathways for Proton Transfer in Cytochrome <i>bc</i>₁. [PDF]

J Chem Inf Model
Camilo SRG, Arantes GM.
europepmc   +1 more source

A theoretical study on the acid‐catalyzed disproportionation reaction of a Mn(IV)‐oxo porphyrin complex

Bulletin of the Korean Chemical Society, EarlyView.
How do disproportionation reactions occur in high‐valent metal‐oxo species? We aim to describe the reaction mechanism of how a synthetic MnIVO‐porphyrin species disproportionates to a formal MnV and MnIII species, using density functional theory.
Steiny Russelisaac Premakumari, Yunhee Choi, Maggie Ng, Vandana Kardam, Wonwoo Nam, Kyung‐Bin Cho   +5 more
wiley   +1 more source

Adaptive evolution of cytochrome b in songbirds. [PDF]

Biol Open
Rottenberg H.
europepmc   +1 more source