Cytoskeletal Expression and Remodeling in Pluripotent Stem Cells. [PDF]
PLoS ONE, 2016 Many emerging cell-based therapies are based on pluripotent stem cells, though complete understanding of the properties of these cells is lacking. In these cells, much is still unknown about the cytoskeletal network, which governs the mechanoresponse ...
Liana C Boraas +3 more
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LRCH proteins: a novel family of cytoskeletal regulators. [PDF]
PLoS ONE, 2010 Comparative genomics has revealed an unexpected level of conservation for gene products across the evolution of animal species. However, the molecular function of only a few proteins has been investigated experimentally, and the role of many animal ...
Hélène Foussard +5 more
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Novel components of the Toxoplasma inner membrane complex revealed by BioID. [PDF]
, 2015 UNLABELLED:The inner membrane complex (IMC) of Toxoplasma gondii is a peripheral membrane system that is composed of flattened alveolar sacs that underlie the plasma membrane, coupled to a supporting cytoskeletal network. The IMC plays important roles in
Bell, Hannah N +11 more
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Reversal of aging-induced increases in aortic stiffness by targeting cytoskeletal protein-protein interfaces [PDF]
, 2018 BACKGROUND: The proximal aorta normally functions as a critical shock absorber that protects small downstream vessels from damage by pressure and flow pulsatility generated by the heart during systole.
Chiu, Joanna +10 more
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PI3K/AKT Signaling Tips the Balance of Cytoskeletal Forces for Cancer Progression
Cancers, 2022 Simple Summary The PI3K/AKT signaling pathway plays critical roles in regulating a series of cellular changes to promote tumor development and progression.
Shuo Deng +5 more
semanticscholar +1 more source
Inhibition of neurite outgrowth in differentiating mouse N2a neuroblastoma cells by phenyl saligenin phosphate: Effects on MAP kinase (ERK 1/2) activation, neurofilament heavy chain phosphorylation and neuropathy target esterase activity [PDF]
, 2006 Sub-lethal concentrations of the organophosphate phenyl saligenin phosphate (PSP) inhibited the outgrowth of axon-like processes in differentiating mouse N2a neuroblastoma cells (IC50 2.5 μM).
Abou-Donia +56 more
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The Emerging Role of the Cytoskeleton in Chromosome Dynamics
Frontiers in Genetics, 2017 Chromosomes underlie a dynamic organization that fulfills functional roles in processes like transcription, DNA repair, nuclear envelope stability, and cell division.
Maya Spichal, Emmanuelle Fabre
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Cytoskeletal disorganization underlies PABPN1-mediated myogenic disability
Scientific Reports, 2020 Muscle wasting and atrophy are regulated by multiple molecular processes, including mRNA processing. Reduced levels of the polyadenylation binding protein nucleus 1 (PABPN1), a multifactorial regulator of mRNA processing, cause muscle atrophy.
Cyriel Sebastiaan Olie +10 more
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The mechano-chemistry of cytoskeletal force generation [PDF]
, 2014 In this communication, we propose a model to study the non-equilibrium process by which actin stress fibers develop force in contractile cells. The emphasis here is on the non-equilibrium thermodynamics, which is necessary to address the mechanics as ...
Garikipati, Krishna, Maraldi, Mirko
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An ongoing role for structural sarcomeric components in maintaining Drosophila melanogaster muscle function and structure. [PDF]
PLoS ONE, 2014 Animal muscles must maintain their function while bearing substantial mechanical loads. How muscles withstand persistent mechanical strain is presently not well understood.
Alexander D Perkins, Guy Tanentzapf
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