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The Expanding Arsenal of Cytotoxic T Cells [PDF]
Frontiers in Immunology, 2022 Cytotoxic T cells (CTLs) are the main cellular mediators of the adaptive immune defenses against intracellular pathogens and malignant cells. Upon recognition of specific antigen on their cellular target, CTLs assemble an immunological synapse where they
Chiara Cassioli, Cosima T. Baldari
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Journal of Investigative Dermatology, 2006 The immune system is a complex arrangement of cells and molecules that preserve the integrity of the organism by elimination of all elements judged dangerous. Within the immune system, a humoral and a cellular as well as an innate and an adaptive arm can be differentiated.
Andersen, Mads Hald +3 more
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Frontiers in Immunology, 2022 Cytotoxic CD4+ T cells (CD4-CTLs) show the presence of cytolytic granules, which include the enzymes granzyme and perforin. The cells have a pathogenic and protective role in various diseases, including cancer, viral infection, and autoimmune disease. In
Shun Tanemoto +22 more
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Arginase-2-specific cytotoxic T cells specifically recognize functional regulatory T cells
Journal for ImmunoTherapy of Cancer, 2022 Background High expression of the metabolic enzyme arginase-2 (ARG2) by cancer cells, regulatory immune cells, or cells of the tumor stroma can reduce the availability of arginine (L-Arg) in the tumor microenvironment (TME).
Marco Donia +14 more
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The Era of Cytotoxic CD4 T Cells
Frontiers in Immunology, 2022 In 1986, Mosmann and Coffman identified 2 functionally distinct subsets of activated CD4 T cells, Th1 and Th2 cells, being key in distinct T cell mediated responses.
Mara Cenerenti +7 more
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Imbalance between subsets of CD8+ peripheral blood T cells in patients with chronic obstructive pulmonary disease [PDF]
PeerJ, 2016 Background. CD8+ T lymphocytes are known to play a critical role in the pathogenesis of chronic obstructive pulmonary disease (COPD). However, systematic analyses of CD8+ T cell (Cytotoxic T cells, Tc) subsets in COPD patients have yet to be well ...
Long Chen +9 more
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Impaired Cytotoxic CD8+ T Cell Response in Elderly COVID-19 Patients
mBio, 2020 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection induces a T cell response that most likely contributes to virus control in COVID-19 patients but may also induce immunopathology. Until now, the cytotoxic T cell response has not been
Jaana Westmeier +19 more
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The effect of SMAD4 on the prognosis and immune response in hypopharyngeal carcinoma
Frontiers in Medicine, 2023 ObjectivesIn malignant tumors, elevated infiltration of intratumoral CD8+ cytotoxic T cells predicts a beneficial prognosis, whereas high levels of CD15+ neutrophils in peritumor tissues indicate poor prognosis.
Juanjuan Song +5 more
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Медицинская иммунология, 2021 The aim of current study was to compare profiles of T cell subsets in the patients with ankylosing spondylitis (AS) who received different modes of genetically engineered biological therapy (GEBT).
A. A. Savchenko +6 more
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Cytotoxic CD4 T cells in the mucosa and in cancer
Frontiers in Immunology, 2023 CD4 T cells were initially described as helper cells that promote either the cellular immune response (Th1 cells) or the humoral immune response (Th2 cells).
Hrishi Venkatesh +5 more
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