Results 11 to 20 of about 490,775 (241)

Distinct Roles of Vav Family Members in Adaptive and Innate Immune Models of Arthritis

Biomedicines, 2021
Genetic evidence suggests that three members of the VAV family (VAV1, VAV2 and VAV3) of signal transduction proteins could play important roles in rheumatoid arthritis.
Javier Conde, Isabel Fernández-Pisonero, Myriam Cuadrado, Antonio Abad, Javier Robles-Valero, Xosé R. Bustelo   +5 more
doaj   +1 more source

Maintenance of Functional CD57+ Cytolytic CD4+ T Cells in HIV+ Elite Controllers

Frontiers in Immunology, 2019
Cytolytic CD4+ T cells play a prominent role in chronic viral infection. CD4+ CTLs clones specific for HIV-1 Nef and Gag are capable of killing HIV-1 infected CD4+ T cells and macrophages.
Chansavath Phetsouphanh, Daniel Aldridge, Emanuele Marchi, C. Mee Ling Munier, Jodi Meyerowitz, Lyle Murray, Cloete Van Vuuren, Dominique Goedhals, Sarah Fidler, Anthony Kelleher, Paul Klenerman, John Frater   +11 more
doaj   +1 more source

Diminished Frequencies of Cytotoxic Marker Expressing T- and NK Cells at the Site of Mycobacterium tuberculosis Infection

Frontiers in Immunology, 2020
Tuberculous lymphadenitis (TBL) individuals exhibit reduced frequencies of CD8+ T cells expressing cytotoxic markers in peripheral blood. However, the frequencies of cytotoxic marker expressing CD4+, CD8+ T cells, and NK cells at the site of infection is
Gokul Raj Kathamuthu, Gokul Raj Kathamuthu, Kadar Moideen, Rathinam Sridhar, Dhanaraj Baskaran, Subash Babu, Subash Babu   +6 more
doaj   +1 more source

CCR6 and CXCR6 Identify the Th17 Cells With Cytotoxicity in Experimental Autoimmune Encephalomyelitis

Frontiers in Immunology, 2022
Due to the plasticity of IL-17-producing CD4 T cells (Th17 cells), a long-standing challenge in studying Th17-driven autoimmune is the lack of specific surface marker to identify the pathogenic Th17 cells in vivo.
Lifei Hou, Lifei Hou, Koichi Yuki, Koichi Yuki   +3 more
doaj   +1 more source

Differential Cytotoxic Function of Resident and Non-resident CD8+ T Cells in the Human Female Reproductive Tract Before and After Menopause

Frontiers in Immunology, 2020
The functional characterization and regulation of tissue resident and non-resident CD8+ T cells in the human female reproductive tract (FRT) as women age remains a gap in our knowledge.
Marta Rodriguez-Garcia, Marta Rodriguez-Garcia, Zheng Shen, Jared M. Fortier, Charles R. Wira   +4 more
doaj   +1 more source

A20 controls macrophage to elicit potent cytotoxic CD4(+) T cell response. [PDF]

PLoS ONE, 2012
Emerging evidence indicates that CD4(+) T cells possess cytotoxic potential for tumor eradication and perforin/granzyme-mediated cytotoxicity functions as one of the important mechanisms for CD4(+) T cell-triggered cell killing.
Lifeng Wang, Bangxing Hong, Xiaoxia Jiang, Lindsey Jones, Si-Yi Chen, Xue F Huang   +5 more
doaj   +1 more source

Cytotoxic T cells and mycobacteria [PDF]

FEMS Microbiology Letters, 2001
How the immune system kills Mycobacterium tuberculosis is still a puzzle. The classical picture of killing due to phagocytosis by activated macrophages may be only partly correct. Based on recent evidence, we express here the view that cytotoxic T lymphocytes also make an important contribution and suggest that DNA vaccines might be a good way to ...
C L, Silva, V L, Bonato, K M, Lima, A A, Coelho-Castelo, L H, Faccioli, A, Sartori, A O, De Souza, S C, Leão   +7 more
openaire   +2 more sources

Adjuvant activity of ethanol extract of Hippophae rhamnoides leaves with inactivated rabies virus antigen

Pharmaceutical Biology, 2018
Context: Hippophae rhamnoides L. (Elaeagnaceae), commonly known as seabuckthorn (SBT), is known for its medicinal and nutritional properties. Objective: Evaluation of in vivo adjuvant activity of SBT leaf extract (SBTE) with inactivated rabies virus ...
D. Singh, B. Jayashankar, K. P. Mishra, H. Tanwar, S. N. Madhusudana, A. Y. Belludi, R. Tulsawani, S. B. Singh, L. Ganju   +8 more
doaj   +1 more source

Regulatory T-Cells Suppress Cytotoxic T Lymphocyte Responses against Microglia

Cells, 2022
Regulatory T-cells (Tregs) play pivotal roles during infection, cancer, and autoimmunity. In our previous study, we demonstrated a role for the PD-1:PD-L1 pathway in controlling cytolytic responses of CD8+ T lymphocytes against microglial cells ...
Priyanka Chauhan, Shuxian Hu, Wen S. Sheng, James R. Lokensgard   +3 more
doaj   +1 more source

Comparative Analysis of Extracellular Vesicles from Cytotoxic CD8⁺ αβ T Cells and γδ T Cells

Cells
Background: Although belonging to different branches of the immune system, cytotoxic CD8+ αβ T cells and γδ T cells utilize common cytolytic effectors including FasL, granzymes, perforin and granulysin.
Lisa Griesel, Patrick Kaleja, Andreas Tholey, Marcus Lettau, Ottmar Janssen   +4 more
doaj   +1 more source