Results 11 to 20 of about 390,147 (250)

Damage-associated molecular patterns (DAMPs) in diseases: implications for therapy

Molecular Biomedicine
Damage-associated molecular patterns (DAMPs) are endogenous danger signal molecules released by damaged, stressed or dead cells that bind to pattern recognition receptors (PRRs), activating immune responses and inflammatory signaling pathways to play ...
Heya Lin, Wei Xiong, Lili Fu, Jie Yi, Jiantang Yang   +4 more
doaj   +5 more sources

Mitochondria-Derived Damage-Associated Molecular Patterns in Neurodegeneration [PDF]

Frontiers in Immunology, 2017
Inflammation is increasingly implicated in neurodegenerative disease pathology. As no acquired pathogen appears to drive this inflammation, the question of what does remains.
Russell H. Swerdlow, Russell H. Swerdlow, Russell H. Swerdlow, Russell H. Swerdlow, Heather M. Wilkins, Heather M. Wilkins, Ian W. Weidling, Ian W. Weidling, Yan Ji, Yan Ji   +9 more
doaj   +3 more sources

Damage-Associated Molecular Patterns (DAMPs) in Retinal Disorders [PDF]

International Journal of Molecular Sciences, 2022
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules released from the extracellular and intracellular space of damaged tissue or dead cells. Recent evidence indicates that DAMPs are associated with the sterile inflammation caused by aging, increased ocular pressure, high glucose, oxidative stress, ischemia, mechanical trauma ...
Binapani Mahaling, Shermaine W. Y. Low, Molly Beck, Devesh Kumar, Simrah Ahmed, Thomas B. Connor, Baseer Ahmad, Shyam S. Chaurasia   +7 more
openaire   +2 more sources

Immune functions of pattern recognition receptors in Lepidoptera

Frontiers in Immunology, 2023
Pattern recognition receptors (PRRs), as the “sensors” in the immune response, play a prominent role in recognizing pathogen-associated molecular patterns (PAMPs) and initiating an effective defense response to pathogens in Lepidoptera.
Lin Zhao, Jinlan Niu, Disong Feng, Xialu Wang, Rong Zhang   +4 more
doaj   +1 more source

Damage associated molecular pattern molecules [PDF]

Clinical Immunology, 2007
Members of the Federation of Clinical Immunology Societies are invited to attend an exciting meeting on damage associated molecular pattern molecules [DAMPs] in acute and chronic inflammation including cancer. This day long interactive symposium is going to be held in San Diego June 7th, 2007 as part of the Annual FOCiS meeting. The Clinical Immunology
Michael T, Lotze, Albert, Deisseroth, Anna, Rubartelli   +2 more
openaire   +2 more sources

Damage-associated molecular patterns in trauma [PDF]

European Journal of Trauma and Emergency Surgery, 2019
AbstractIn 1994, the “danger model” argued that adaptive immune responses are driven rather by molecules released upon tissue damage than by the recognition of “strange” molecules. Thus, an alternative to the “self versus non-self recognition model” has been provided.
Relja, Borna, Land, Walter Gottlieb
openaire   +2 more sources

The Role of HMGB1 in Rheumatic Diseases

Frontiers in Immunology, 2022
HMGB1, a highly conserved non-histone nuclear protein, is widely expressed in mammalian cells. HMGB1 in the nucleus binds to the deoxyribonucleic acid (DNA) to regulate the structure of chromosomes and maintain the transcription, replication, DNA repair,
Yuanji Dong, Bingxia Ming, Lingli Dong
doaj   +1 more source

Ferroptosis becomes immunogenic: implications for anticancer treatments

OncoImmunology, 2021
Ferroptosis is an iron-dependent form of non-apoptotic cell death that has recently been attributed with antitumor immune effects. Thus, early ferroptotic cells underwent immunogenic cell death that was accompanied by the emission of damage-associated ...
Daolin Tang, Oliver Kepp, Guido Kroemer
doaj   +1 more source

Radiochemotherapy-induced elevations of plasma HMGB1 levels predict therapeutic responses in cancer patients

OncoImmunology, 2021
High mobility group B1 (HMGB1) is a protein that is released from dying cancer cells in the context of immunogenic cell death (ICD). A recent study performed on patients with head and neck squamous cell carcinomas (HNSCC) reports that a chemoradiotherapy-
Guido Kroemer, Oliver Kepp
doaj   +1 more source

Damage-Associated Molecular Patterns in Inflammatory Diseases [PDF]

Immune Network, 2018
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules that are released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors (PRRs). Although DAMPs contribute to the host's defense, they promote pathological inflammatory responses.
Roh, Jong Seong, Sohn, Dong Hyun
openaire   +2 more sources