Results 21 to 30 of about 390,147 (250)
Kinetics of Circulating Damage-Associated Molecular Patterns in Sepsis [PDF]
Journal of Immunology Research, 2015 Circulating levels of conventional biomarkers and damage-associated molecular patterns were examined in 30 severe sepsis patients (20 survivors and 10 nonsurvivors). Plasma levels of interleukin 6, CRP, and procalcitonin reached their peaks on Day 0 (onset of sepsis) or Day 1 and declined rapidly thereafter despite the persistent severity. In contrast,
Takahiro Miki, Toshiaki Iba
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Inflammaging as the basis of age-associated diseases
Медицинская иммунология, 2020 Aging is one of the most complex biological phenomena that affects all human physiological systems, including the immune system. Immunosenescence is understood as structural and functional changes in both adaptive and innate immunity systems.
O. V. Artemyeva, L. V. Gankovskaya
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Mitochondrial damage-associated molecular patterns and vascular function [PDF]
European Heart Journal, 2014 Immune system activation occurs not only due to foreign stimuli, but also due to endogenous molecules. As such, endogenous molecules that are released into the circulation due to cell death and/or injury alarm the immune system that something has disturbed homeostasis and a response is needed.
Camilla Ferreira, Wenceslau +5 more
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The Roles of Mitochondrial Damage-Associated Molecular Patterns in Diseases [PDF]
Antioxidants & Redox Signaling, 2015 Mitochondria, vital cellular power plants to generate energy, are involved in immune responses. Mitochondrial damage-associated molecular patterns (DAMPs) are molecules that are released from mitochondria to extracellular space during cell death and include not only proteins but also DNA or lipids.
Kiichi, Nakahira +2 more
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nflammation and damage-associated molecular patterns in major psychiatric disorders
Trends in Psychiatry and Psychotherapy, 2023 Emerging evidence indicates that inflammation plays an important role as a mechanism underlying mental disorders. However, most of the research on inflammatory mechanisms focuses on serum levels of interleukins and very few studies have investigated molecules that initiate and expand innate immune pathways such as damage-associated molecular patterns ...
Fernanda Endler Valiati +7 more
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Breaking Bad News: Dynamic Molecular Mechanisms of Wound Response in Plants
Frontiers in Plant Science, 2020 Recognition and repair of damaged tissue are an integral part of life. The failure of cells and tissues to appropriately respond to damage can lead to severe dysfunction and disease. Therefore, it is essential that we understand the molecular pathways of
Isaac Vega-Muñoz +11 more
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Damage-Associated Molecular Patterns Control Neutrophil Recruitment [PDF]
Journal of Innate Immunity, 2013 Neutrophils are recruited to a site of infection or injury where they help initiate the acute inflammatory response. In instances of sterile inflammation, where no microbial threats are present, this neutrophil recruitment is mediated by the release of danger signals or damage-associated molecular patterns (DAMPs) from disrupted cells and tissues.
Keir, Pittman, Paul, Kubes
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Identification and Biological Activity of Synthetic Macrophage Inducible C-Type Lectin Ligands
Frontiers in Immunology, 2018 The macrophage inducible C-type lectin (Mincle) is a pattern recognition receptor able to recognize both damage-associated and pathogen-associated molecular patterns, and in this respect, there has been much interest in determining the scope of ligands ...
Chriselle D. Braganza +7 more
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Pharmaceutics, 2023 The kinase activity of inhibitory κB kinase β (IKKβ) acts as a signal transducer in the activating pathway of nuclear factor-κB (NF-κB), a master regulator of inflammation and cell death in the development of numerous hepatocellular injuries.
Song-Hee Kim +9 more
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Transplantation and Damage-Associated Molecular Patterns (DAMPs)
American Journal of Transplantation, 2016 Upon solid organ transplantation and during cancer immunotherapy, cellular stress responses result in the release of damage-associated molecular patterns (DAMPs). The various cellular stresses have been characterized in detail over the last decades, but a unifying classification based on clinically important aspects is lacking.
Land, W.G. +4 more
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