Results 211 to 220 of about 375,454 (242)

Damage-Associated Molecular Patterns As Double-Edged Swords in Sepsis

Antioxidants & Redox Signaling, 2021
Significance: Sepsis is defined as a life-threatening organ dysfunction caused by dysregulated host response to infection. This leads to an uncontrolled inflammatory response at the onset of infection, followed by immunosuppression. The development of a specific treatment modality for sepsis is still challenging,
Mian, Zhou, Monowar, Aziz, Ping, Wang
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Elevated levels of damage-associated molecular patterns HMGB1 and S100A8/A9 coupled with toll-like receptor-triggered monocyte activation are associated with inflammation in patients with myelofibrosis [PDF]

Frontiers in Immunology
Paola R Lev, Moiraghi BEATRIZ
exaly   +2 more sources

Damage-Associated Molecular Patterns and Systemic Signaling

Phytopathology®
Cellular damage inflicted by wounding, pathogen infection, and herbivory releases a variety of host-derived metabolites, degraded structural components, and peptides into the extracellular space that act as alarm signals when perceived by adjacent cells.
Fiona M. Harris, Zhonglin Mou
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Extracellular histones as damage-associated molecular patterns in neuroinflammatory responses

Reviews in the Neurosciences, 2022
Abstract The four core histones H2A, H2B, H3, H4, and the linker histone H1 primarily bind DNA and regulate gene expression within the nucleus. Evidence collected mainly from the peripheral tissues illustrates that histones can be released into the extracellular space by activated or damaged cells. In this article, we first summarize the
Christy M. Richards, Seamus A. McRae, Athena L. Ranger, Andis Klegeris   +3 more
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Damage-associated molecular patterns and their pathological relevance in diabetes mellitus

Ageing Research Reviews, 2015
Diabetes, a group of metabolic and age-related diseases, is a major global health problem, the incidence of which has increased dramatically in recent decades. Type 1 diabetes mellitus (T1DM) is a complex, T cell-mediated autoimmune disease characterized by immune cell infiltration and chronic inflammation in the islets of Langerhans.
Shin, Jung Jae, Lee, Eun Kyung, Park, Tae Joo, Kim, Wook   +3 more
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Damage‐Associated Molecular Patterns in the Course of Lung Cancer – A Review

Scandinavian Journal of Immunology, 2015
AbstractMore than 20 years ago, the ‘danger theory’ was proposed which explains why potent immune responses with no microbial components are elicited against tissue transplants, injuries, tumours and autoimmune diseases. It states that the immune system can distinguish between dangerous and innocuous endogenous signals.
M, Łagiedo, J, Sikora, M, Kaczmarek
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Damage-associated molecular patterns and their receptors in upper airway pathologies

Cellular and Molecular Life Sciences, 2013
Inflammation of the nasal (rhinitis) and sinus mucosa (sinusitis) are prevalent medical conditions of the upper airways that are concurrent in many patients; hence the terminology "rhinosinusitis". The disease status is further defined to be "chronic" in case symptoms persist for more than 12 weeks without resolution.
Koen, Van Crombruggen, Fenila, Jacob, Nan, Zhang, Claus, Bachert   +3 more
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Preeclampsia and damage — associated molecular patterns

Rossiiskii vestnik akushera-ginekologa, 2021
V.I. Shcherbakov, I.M. Pozdnyakov, A.V. Shirinskaya   +2 more
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[Damage-associated molecular patterns and chronic diseases].

Sheng li ke xue jin zhan [Progress in physiology], 2012
Molecules of damage-associated molecular patterns (DAMPs) are a class of substances released to intercellular space or peripheral blood by tissues or cells which are stimulated by insults, ischemia or stress. DAMP molecules can be recognized by Toll like receptors, Nod1-like receptors, or Rig-I like receptors and induce autoimmunity or immune tolerance,
Hong-Zhen, Yang, Wen-Feng, Cai, Zhuo-Wei, Hu   +2 more
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[Damage-associated molecular patterns and liver failure].

Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology, 2017
Damage-associated molecular patterns (DAMPs) are a series of intracellular molecules with immunoregulatory activity which are released by the damaged or activated cells and can induce autoimmunity or immune tolerance via pattern recognition receptors.
Y Y, Yan, S, Lin, Y Y, Zhu
openaire   +1 more source