Curcumin induces immunogenic cell death in murine colorectal carcinoma CT26 cells
Pharmacological Research - Modern Chinese Medicine, 2022 Different stressors of the endoplasmic reticulum (ER) can trigger immunogenic cell death (ICD), a modality of regulated cell death that can be therapeutically used to induce antitumor immune responses. Curcumin has been pointed out as an ER stressor, but
Rayane Ganassin +7 more
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The Role of C-Type Lectin Receptor Signaling in the Intestinal Microbiota-Inflammation-Cancer Axis
Frontiers in Immunology, 2022 As a subset of pattern recognition receptors (PRRs), C-type lectin-like receptors (CLRs) are mainly expressed by myeloid cells as both transmembrane and soluble forms.
Muhan Li +7 more
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Damage-Associated Molecular Patterns Control Neutrophil Recruitment [PDF]
Journal of Innate Immunity, 2013 Neutrophils are recruited to a site of infection or injury where they help initiate the acute inflammatory response. In instances of sterile inflammation, where no microbial threats are present, this neutrophil recruitment is mediated by the release of danger signals or damage-associated molecular patterns (DAMPs) from disrupted cells and tissues.
Keir, Pittman, Paul, Kubes
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Mechanisms of Immunothrombosis by SARS-CoV-2
Biomolecules, 2021 SARS-CoV-2 contains certain molecules that are related to the presence of immunothrombosis. Here, we review the pathogen and damage-associated molecular patterns.
María Teresa Hernández-Huerta +12 more
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Identification of CNS Injury-Related microRNAs as Novel Toll-Like Receptor 7/8 Signaling Activators by Small RNA Sequencing [PDF]
, 2020 Toll-like receptors (TLRs) belong to pattern recognition receptors, which respond to danger signals such as pathogen-associated molecular patterns or damage-associated molecular patterns.
Buonfiglioli, Alice +7 more
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Frontiers in Plant Science, 2021 In response to herbivore attack, plants release large amounts of volatiles that can serve as attractants for the natural enemies of the attacking herbivores. Such responses are typically triggered by damage- and insect-associated factors.
Carla M. Arce +3 more
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Damage-Associated Molecular Patterns in Inflammatory Diseases [PDF]
Immune Network, 2018 Damage-associated molecular patterns (DAMPs) are endogenous danger molecules that are released from damaged or dying cells and activate the innate immune system by interacting with pattern recognition receptors (PRRs). Although DAMPs contribute to the host's defense, they promote pathological inflammatory responses.
Roh, Jong Seong, Sohn, Dong Hyun
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Kawasaki Disease Following Severe Sunburn Injury
Frontiers in Pediatrics, 2020 Background: Although an etiology of Kawasaki disease (KD) is unknown, an aberrant innate immune system in predisposed individuals has been proposed to play a key role in the development of KD vasculitis.
Seigo Okada +7 more
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Danger signals in traumatic hemorrhagic shock and new lines for clinical applications
Frontiers in Physiology, 2023 Hemorrhage is the leading cause of death in severe trauma injuries. When organs or tissues are subjected to prolonged hypoxia, danger signals—known as damage-associated molecular patterns (DAMPs)—are released into the intercellular environment.
Frédérique Dufour-Gaume +3 more
doaj +1 more source
Tissue Microenvironments Define and Get Reinforced by Macrophage Phenotypes in Homeostasis or during Inflammation, Repair and Fibrosis [PDF]
, 2012 Current macrophage phenotype classifications are based on distinct in vitro culture conditions that do not adequately mirror complex tissue environments.
Weidenbusch, Marc, Anders, Hans-Joachim
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