Results 51 to 60 of about 763,623 (189)

Mitochondrial damage-associated molecular patterns trigger arginase-dependent lymphocyte immunoregulation

Cell Reports, 2022
Tissue damage leads to loss of cellular and mitochondrial membrane integrity and release of damage-associated molecular patterns, including those of mitochondrial origin (mitoDAMPs). Here, we describe the lymphocyte response to mitoDAMPs. Using primary cells from mice and human donors, we demonstrate that natural killer (NK) cells and T cells adopt ...
Lauren P, Westhaver, Sarah, Nersesian, Adam, Nelson, Leah K, MacLean, Emily B, Carter, Derek, Rowter, Jun, Wang, Boris L, Gala-Lopez, Andrew W, Stadnyk, Brent, Johnston, Jeanette E, Boudreau   +10 more
openaire   +2 more sources

Damage-Associated Molecular Patterns and Pattern Recognition Receptors in the Podocyte.

J Am Soc Nephrol
Podocytes possess immune system components allowing for a variety of innate responses to endogenous and exogenous stimuli. Recently, several groups have linked inappropriate innate immune signaling to podocyte injury, particularly chronic, sustained injury; however, the immune capabilities of podocytes have not been fully elucidated.
Myette RL, Trentin-Sonoda M, Landry C, Holterman CE, Lin T, Burger D, Kennedy CRJ.   +6 more
europepmc   +3 more sources

DNA methylation dynamics in aging: How far are we from understanding the mechanisms? [PDF]

, 2018
DNA methylation is currently the most promising molecular marker for monitoring aging and predicting life expectancy. However, the mechanisms underlying age-related DNA methylation changes remain mostly undiscovered.Here we discuss the current knowledge ...
Caiafa, Paola, Ciccarone, Fabio, Tagliatesta, Stefano, Zampieri, Michele   +3 more
core   +1 more source

Damage-associated molecular patterns in cancer: a double-edged sword [PDF]

Oncogene, 2016
Damage-associated molecular patterns (DAMPs) are released in response to cell death and stress, and are potent triggers of sterile inflammation. Recent evidence suggests that DAMPs may also have a key role in the development of cancer, as well as in the host response to cytotoxic anti-tumor therapy.
Hernandez, Celine, Huebener, Peter, Schwabe, Robert F.   +2 more
openaire   +2 more sources

Case Report: Kawasaki disease associated with acute generalized exanthematous pustulosis secondary to carbocysteine

Frontiers in Pediatrics
Acute generalized exanthematous pustulosis (AGEP) is an uncommon eruption characterized by sterile pustules on an erythematous background, which is usually associated with drugs. AGEP is described as a self-limiting disease with favorable prognosis.
Takashi Furuta, Hiroyuki Fukumoto, Mayu Fujiwara, Shinnosuke Fukunaga, Yuichi Ishikawa, Reiji Hirano   +5 more
doaj   +1 more source

One special question to start with: can HIF/NFkB be a target in inflammation? [PDF]

, 2015
Hypoxia and Inflammation are strictly interconnected with important consequences at clinical and therapeutic level. While cell and tissue damage due to acute hypoxia mostly leads to cell necrosis, in chronic hypoxia, cells that are located closer to ...
CARNEVALE, ILARIA, DE SANTIS, Elena, Limana, F, Perrone, Ga, POLLETTA, LUCIA, RUNCI, ALESSANDRA, RUSSO, Matteo Antonio, SANSONE, LUIGI, TAFANI, MARCO   +8 more
core   +1 more source

Enhancing acute inflammatory and sepsis treatment: superiority of membrane receptor blockade

Frontiers in Immunology
Conditions such as acute pancreatitis, ulcerative colitis, delayed graft function and infections caused by a variety of microorganisms, including gram-positive and gram-negative organisms, increase the risk of sepsis and therefore mortality.
Seok-Jun Mun, Seok-Jun Mun, Euni Cho, Euni Cho, Hyo Keun Kim, Hyo Keun Kim, Woo Jin Gil, Woo Jin Gil, Chul-Su Yang, Chul-Su Yang, Chul-Su Yang   +10 more
doaj   +1 more source

Therapeutic Opportunities in Damage-Associated Molecular Pattern-Driven Metabolic Diseases [PDF]

Antioxidants & Redox Signaling, 2015
Sterile inflammation is a common finding present in various metabolic disorders. This type of inflammation is mediated by damage-associated molecular patterns (DAMPs) that are released upon cellular injury to activate pattern recognition receptors on innate immune cells and amplify organ damage.In the last decade, DAMPs, such as high-mobility group ...
Irma, Garcia-Martinez, Mohamed E, Shaker, Wajahat Z, Mehal   +2 more
openaire   +2 more sources

Helicobacter Pylori Infection and Lung Cancer: 
New Insights and Future Challenges

Chinese Journal of Lung Cancer, 2018
Helicobacter pylori (H. pylori) is the causative agent of chronic gastritis and peptic ulcer diseases and is an important risk factor for the development functional dyspepsia, peptic ulceration, gastric adenocarcinoma and mucosa-associated lymphoid ...
Ileana GONZÁLEZ, Paulina ARAYA, Armando ROJAS   +2 more
doaj   +1 more source

Innate Immune Activity in Glomerular Podocytes [PDF]

, 2017
Glomerular podocytes are specialized in structure and play an essential role in glomerular filtration. In addition, podocyte stress can initiate glomerular damage by inducing the injury of other glomerular cell types.
Hong Xia, Shaolin Shi, Wenduona Bao
core   +1 more source