Results 51 to 60 of about 59,000 (187)
A proteomic atlas of senescence-associated secretomes for aging biomarker development. [PDF]
, 2020 The senescence-associated secretory phenotype (SASP) has recently emerged as a driver of and promising therapeutic target for multiple age-related conditions, ranging from neurodegeneration to cancer.
Basisty, Nathan +11 more
core +1 more source
In silico selection of damage-associated molecular patterns (DAMPS) and their receptors in humans
Research, Society and Development, 2022 Damage-associated molecular patterns (DAMPs) are intracellular molecules released into the extracellular environment after injury. These are recognized by pattern recognition receptors (PRRs) and activate the innate immune system, triggering an inflammatory response.
Erika Aparecida Oliveira +6 more
openaire +2 more sources
Delivery of mixed-lineage kinase domain-like protein by vapor nanobubble photoporation induces necroptotic-like cell death in tumor cells [PDF]
, 2019 Modern molecular medicine demands techniques to efficiently deliver molecules directly into mammalian cells. As proteins are the final mediators of most cellular pathways, efficient intracellular protein delivery techniques are highly desired.
Braeckmans, Kevin +10 more
core +2 more sources
Tissue Microenvironments Define and Get Reinforced by Macrophage Phenotypes in Homeostasis or during Inflammation, Repair and Fibrosis [PDF]
, 2012 Current macrophage phenotype classifications are based on distinct in vitro culture conditions that do not adequately mirror complex tissue environments.
Weidenbusch, Marc, Anders, Hans-Joachim
core +1 more source
Damage‐associated molecular patterns (DAMPs) and mesenchymal stem cells: A matter of attraction and excitement [PDF]
European Journal of Immunology, 2011 AbstractNecrotic cell death is a typical feature of solid tumors leading to the release of necrotic products, also known as damage‐associated molecular patterns (DAMPs), that enhance angiogenesis and prime the immune response. Among the DAMPs, particular attention has been focused on the DNA‐binding molecule high‐mobility group box 1 (HMGB‐1) that can ...
Vito, Pistoia, Lizzia, Raffaghello
openaire +2 more sources
Alarmins, inflammasomes and immunity
Biomedical Journal, 2012 The elaboration of an effective immune response against pathogenic microbes such as viruses, intracellular bacteria or protozoan parasites relies on the recognition of microbial products called pathogen-associated molecular patterns (PAMPs) by pattern ...
Najwane Saïd-Sadier, David M Ojcius
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2022 Atherosclerosis is a chronic artery disease characterized by plaque formation and vascular inflammation, eventually leading to myocardial infarction and stroke.
Xuanzhi Zhu, Hanyao Huang, Lei Zhao
doaj +1 more source
DAMPening Inflammation by Modulating TLR Signalling
Mediators of Inflammation, 2010 Damage-associated molecular patterns (DAMPs) include endogenous intracellular molecules released by activated or necrotic cells and extracellular matrix (ECM) molecules that are upregulated upon injury or degraded following tissue damage.
A. M. Piccinini, K. S. Midwood
doaj +1 more source
Cell Reports, 2014 Cherubism is caused by mutations in SH3BP2. Studies of cherubism mice showed that tumor necrosis factor α (TNF-α)-dependent autoinflammation is a major cause of the disorder but failed to explain why human cherubism lesions are restricted to jaws and ...
Teruhito Yoshitaka +11 more
doaj +1 more source
How does an RNA selfie work? EV-associated RNA in innate immunity as self or danger
Journal of Extracellular Vesicles, 2020 Innate immunity is a first line of defence against danger. Exogenous pathogen- or microbe-associated molecular patterns (PAMPs or MAMPs) trigger innate immune responses through well-understood cellular pathways.
Yu Xiao +4 more
doaj +1 more source