Results 11 to 20 of about 59,000 (187)

Damage-Associated Molecular Patterns (DAMPs) in Retinal Disorders. [PDF]

Int J Mol Sci, 2022
Damage-associated molecular patterns (DAMPs) are endogenous danger molecules released from the extracellular and intracellular space of damaged tissue or dead cells. Recent evidence indicates that DAMPs are associated with the sterile inflammation caused by aging, increased ocular pressure, high glucose, oxidative stress, ischemia, mechanical trauma ...
Mahaling B, Low SWY, Beck M, Kumar D, Ahmed S, Connor TB, Ahmad B, Chaurasia SS.   +7 more
europepmc   +4 more sources

Role of Damage-Associated Molecular Patterns (DAMPS) in the Postoperative Period after Colorectal Surgery. [PDF]

Int J Mol Sci, 2023
Anastomotic leakage (AL) is a defect of the intestinal wall at the anastomotic site and is one of the most severe complications in colorectal surgery. Previous studies have shown that the immune system response plays a significant role in the development of AL.
Caballero-Herrero MJ, Jumilla E, Buitrago-Ruiz M, Valero-Navarro G, Cuevas S.   +4 more
europepmc   +3 more sources

Mitochondrial damage-associated molecular patterns (mito-DAMPs): Determinants of hepatopathy progression and therapeutic implications

Pharmacological Research
Liver diseases, as the primary representative disorders of the digestive tract, encompass metabolic dysfunction-associated steatotic liver disease (MASLD), liver fibrosis, and malignant liver or gallbladder cancers and pose a significant health challenge
Ranyi Luo, Yun Yang, Yinhao Zhang, Xiaoyong Xue, Mengyu Guo, Xiaojiaoyang Li   +5 more
doaj   +2 more sources

Damage-associated molecular patterns (DAMPs) in vascular diseases. [PDF]

J Biol Chem
Research into the role of chronic sterile inflammation (i.e. a prolonged inflammatory state not caused by an infectious agent), in vascular disease progression has continued to grow over the last few decades. DAMPs have a critical role in this research due to their ability to link stress-causing cardiovascular risk factors to inflammatory phenotypes ...
Antonello J, Roy P.
europepmc   +3 more sources

Mitochondrial dysfunction and damage associated molecular patterns (DAMPs) in chronic inflammatory diseases. [PDF]

Mitochondrion, 2018
Inflammation represents a comprehensive host response to external stimuli for the purpose of eliminating the offending agent, minimizing injury to host tissues and fostering repair of damaged tissues back to homeostatic levels. In normal physiologic context, inflammatory response culminates with the resolution of infection and tissue damage response ...
Dela Cruz CS, Kang MJ.
europepmc   +4 more sources

Damage-associated molecular patterns (DAMPs) released after burn are associated with inflammation and monocyte activation. [PDF]

Burns, 2017
Burns are associated with activation of the innate immunity that can contribute to complications. Damage-associated molecular patterns (DAMPs) released after tissue injury play a critical role in the activation of the innate immunity, which appears to be mediated via toll-like receptors (TLRs).
Rani M, Nicholson SE, Zhang Q, Schwacha MG.   +3 more
europepmc   +4 more sources

Neutrophil Extracellular Traps (NETs) and Damage-Associated Molecular Patterns (DAMPs): Two Potential Targets for COVID-19 Treatment. [PDF]

Mediators Inflamm, 2020
COVID-19 is a pandemic disease caused by the new coronavirus SARS-CoV-2 that mostly affects the respiratory system. The consequent inflammation is not able to clear viruses. The persistent excessive inflammatory response can build up a clinical picture that is very difficult to manage and potentially fatal.
Cicco S, Cicco G, Racanelli V, Vacca A.
europepmc   +7 more sources

Fas/CD95 Signaling Pathway in Damage-Associated Molecular Pattern (DAMP)-Sensing Receptors

Cells, 2022
Study of the initial steps of the CD95-mediated signaling pathways is a field of intense research and a long list of actors has been described in the literature. Nonetheless, the dynamism of protein-protein interactions (PPIs) occurring in the presence or absence of its natural ligand, CD95L, and the cellular distribution where these PPIs take place ...
Galli, Gael, Vacher, Pierre, Ryffel, Bernhard, Blanco, Patrick, Legembre, Patrick   +4 more
openaire   +4 more sources

Bullatacin triggers immunogenic cell death of colon cancer cells by activating endoplasmic reticulum chaperones

Journal of Inflammation, 2021
Background It is well accepted that the immune system efficiently contributes to positive outcomes of chemotherapeutic cancer treatment by activating immunogenic cell death (ICD).
Fangtian Fan, Peiliang Shen, Yue Ma, Wangbo Ma, Hongyan Wu, Hao Liu, Qing An   +6 more
doaj   +1 more source

Molecular biology of autoinflammatory diseases

Inflammation and Regeneration, 2021
The long battle between humans and various physical, chemical, and biological insults that cause cell injury (e.g., products of tissue damage, metabolites, and/or infections) have led to the evolution of various adaptive responses.
Junya Masumoto, Wei Zhou, Shinnosuke Morikawa, Sho Hosokawa, Haruka Taguchi, Toshihiro Yamamoto, Mie Kurata, Naoe Kaneko   +7 more
doaj   +1 more source