Results 141 to 150 of about 3,096 (155)
Cytoplasmic regulation of the poly(A) tail length as a potential therapeutic target. [PDF]
RNAFernandez M, Mendez R.
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Haploinsufficiency of Cnot3 Aggravates Acid-Induced Acute Lung Injury Likely Through Transcriptional and Post-Transcriptional Upregulation of Pro-Inflammatory Genes. [PDF]
J Inflamm ResYamaguchi T +11 more
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Multifunctional deadenylase complexes diversify mRNA control
Nature Reviews Molecular Cell Biology, 2008Dynamic changes of the lengths of mRNA poly(A) tails are catalysed by diverse deadenylase enzymes. Modulating the length of the poly(A) tail of an mRNA is a widespread means of controlling protein production and mRNA stability. Recent insights illuminate the specialized activities, biological functions and regulation of deadenylases.
Aaron C, Goldstrohm, Marvin, Wickens
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Biophysical and biochemical characterization of recombinant human Pop2 deadenylase
Protein Expression and Purification, 2008Pop2, a component of the Ccr4-Not complex, functions as a deadenylase both in vitro and in vivo. In this research, we found that the recombinant human Pop2 (hPop2) mainly existed in a compact monomeric state with a a + b tertiary structure type. The percentages of the secondary structures evaluated from the CD spectrum were about 37% a-helix, 14% b ...
Wei-Feng, Liu, Yong-Bin, Yan
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Activity and Function of Deadenylases
2012Shortening of the poly(A) tail is the first and often rate-limiting step in mRNA degradation. Three poly(A)-specific 3' exonucleases have been described that can carry out this reaction: PAN, composed of two subunits; PARN, a homodimer; and the CCR4-NOT complex, a heterooligomer that contains two catalytic subunits and may have additional functions in ...
Christiane, Harnisch +4 more
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PAN-orama: three convergent views of a eukaryotic deadenylase
Nature Structural & Molecular Biology, 2014Post-transcriptional mRNA regulation is often attained by lengthening or shortening the 3′ poly(A) tail of a transcript. Eukaryotic mRNAs show a spectrum of deadenylation rates, thus allowing intricate control of gene expression, but the mechanisms that determine such rates are unclear.
Sophie, Martin, Jeff, Coller
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2023
Deadenylase enzymes play a key role in mRNA degradation and RNA processing. In this chapter, we describe two activity assays for the quantitative biochemical analysis of deadenylase enzymes, which can easily be adapted for other nuclease enzymes. The assays use distinct principles of detection, which are based on differential annealing of a probe ...
Blessing, Airhihen +3 more
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Deadenylase enzymes play a key role in mRNA degradation and RNA processing. In this chapter, we describe two activity assays for the quantitative biochemical analysis of deadenylase enzymes, which can easily be adapted for other nuclease enzymes. The assays use distinct principles of detection, which are based on differential annealing of a probe ...
Blessing, Airhihen +3 more
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Diverse functions of deadenylases in DNA damage response and genomic integrity
WIREs RNA, 2020AbstractDNA damage response (DDR) is a coordinated network of diverse cellular processes including the detection, signaling, and repair of DNA lesions, the adjustment of metabolic network and cell fate determination. To deal with the unavoidable DNA damage caused by either endogenous or exogenous stresses, the cells need to reshape the gene expression ...
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Characterization of the ubiquitin binding properties of the deadenylase Pan2
The FASEB Journal, 2016Messenger RNA (mRNA) stability plays an important role in regulating gene expression in eukaryotic cells. While a number of endo‐ and exo‐nucleolytic enzymes act on mRNA, removal of the poly(A) tail, or deadenylation, is often the first and rate‐limiting step in mRNA decay.
Zachary Swinney +3 more
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