Results 1 to 10 of about 14,150 (193)

Modeling of mRNA deadenylation rates reveal a complex relationship between mRNA deadenylation and decay [PDF]

The EMBO Journal
Complete cytoplasmic polyadenosine tail (polyA-tail) deadenylation is thought to be essential for initiating mRNA decapping and subsequent degradation. To investigate this prevalent model, we conducted direct RNA sequencing of S. cerevisiae mRNAs derived
Agnieszka Czarnocka-Cieciura, Jarosław Poznański, Matti Turtola, Rafał Tomecki, Paweł S Krawczyk, Seweryn Mroczek, Wiktoria Orzeł, Upasana Saha, Torben Heick Jensen, Andrzej Dziembowski, Agnieszka Tudek   +10 more
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Rapid nuclear deadenylation of mammalian messenger RNA [PDF]

iScience, 2023
Summary: Poly(A) tails protect RNAs from degradation and their deadenylation rates determine RNA stability. Although poly(A) tails are generated in the nucleus, deadenylation of tails has mostly been investigated within the cytoplasm.
Jonathan Alles, Ivano Legnini, Maddalena Pacelli, Nikolaus Rajewsky   +3 more
doaj   +5 more sources

Multivalent interactions with CCR4–NOT and PABPC1 determine mRNA repression efficiency by tristetraprolin [PDF]

Nature Communications
Tristetraprolin family of proteins regulate mRNA stability by binding to specific AU-rich elements in transcripts. This binding promotes the shortening of the mRNA poly(A) tail, or deadenylation, initiating mRNA degradation.
Filip Pekovic, Wi S. Lai, Joshua Corbo, Stephanie N. Hicks, Keiko Luke, Perry J. Blackshear, Eugene Valkov   +6 more
doaj   +2 more sources

Preserving the Poly(A) Tail: Strategies Viruses Use to ‘CYA’ (Cover Your A’s) [PDF]

Viruses
The poly(A) tail on viral mRNAs plays an important role in gene expression, given the role of the 3′ mRNA tail in mRNA stability and translation. Viruses have developed several strategies to maintain the integrity of their poly(A) tails.
Jeffrey Wilusz
doaj   +2 more sources

RNA degradation triggered by decapping is largely independent of initial deadenylation [PDF]

The EMBO Journal
RNA stability, important for eukaryotic gene expression, is thought to depend on deadenylation rates, with shortened poly(A) tails triggering decapping and 5′ to 3′ degradation.
Léna Audebert, Frank Feuerbach, Mostafa Zedan, Alexandra P Schürch, Laurence Decourty, Abdelkader Namane, Emmanuelle Permal, Karsten Weis, Gwenaël Badis, Cosmin Saveanu   +9 more
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Maternal mRNA deadenylation is defective in in vitro matured mouse and human oocytes [PDF]

Nature Communications
Oocyte in vitro maturation is a technique in assisted reproductive technology. Thousands of genes show abnormally high expression in in vitro maturated metaphase II (MII) oocytes compared to those matured in vivo in bovines, mice, and humans.
Yusheng Liu, Wenrong Tao, Shuang Wu, Yiwei Zhang, Hu Nie, Zhenzhen Hou, Jingye Zhang, Zhen Yang, Zi-Jiang Chen, Jiaqiang Wang, Falong Lu, Keliang Wu   +11 more
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Recycling of Uridylated mRNAs in Starfish Embryos [PDF]

Biomolecules
In eukaryotes, mRNAs with long poly(A) tails are translationally active, but deadenylation and uridylation of these tails generally cause mRNA degradation. However, the fate of uridylated mRNAs that are not degraded quickly remains obscure.
Haruka Yamazaki, Megumi Furuichi, Mikoto Katagiri, Rei Kajitani, Takehiko Itoh, Kazuyoshi Chiba   +5 more
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Estrogen receptor alpha (ERα) regulates PARN-mediated nuclear deadenylation and gene expression in breast cancer cells [PDF]

RNA Biology
The estrogen signalling pathway is highly dynamic and primarily mediated by estrogen receptors (ERs) that transcriptionally regulate the expression of target genes.
Sophia Varriano, Amy Yu, Yu Qing Xu, Devorah M. Natelson, Anthony Ramadei, Frida E. Kleiman   +5 more
doaj   +2 more sources

MARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA [PDF]

Nature Communications
The mammalian early embryo development requires translation of maternal mRNA inherited from the oocyte. While poly(A) tail length influences mRNA translation efficiency during the oocyte-to-embryo transition (OET), molecular mechanisms regulating ...
Jing Yang, Jiachen Bu, Bowen Liu, Yusheng Liu, Zhuqiang Zhang, Ziyi Li, Falong Lu, Bing Zhu, Yingfeng Li   +8 more
doaj   +2 more sources

An extended wave of global mRNA deadenylation sets up a switch in translation regulation across the mammalian oocyte-to-embryo transition [PDF]

Cell Reports
Summary: Without new transcription, gene expression across the oocyte-to-embryo transition (OET) relies instead on regulation of mRNA poly(A) tails to control translation.
Katherine Lee, Kyucheol Cho, Robert Morey, Heidi Cook-Andersen   +3 more
doaj   +2 more sources