Results 91 to 100 of about 14,150 (193)

Deadenylation-independent stage-specific mRNA degradation in Leishmania [PDF]

Nucleic Acids Research, 2008
The life cycle of Leishmania alternates between developmental forms residing within the insect vector (e.g. promastigotes) and the mammalian host (amastigotes). In Leishmania nearly all control of gene expression is post-transcriptional and involves sequences in the 3'-untranslated regions (3'UTRs) of mRNAs.
Haile, Simon, Dupé, Aurélien, Papadopoulou, Barbara   +2 more
openaire   +2 more sources

Progress in RNA‐Targeted Therapeutics for Human Diseases

MedComm, Volume 7, Issue 2, February 2026.
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang, Aimin Jiang, Bin‐Kui Jia, Yuming Jin, Yinghu Chen, Zhaoyu Li, Yan Liao, Haoling Zhang, Zhiheng Lin, Xiao Fang, Linhui Wang   +10 more
wiley   +1 more source

DEAD-box helicase eIF4A2 inhibits CNOT7 deadenylation activity [PDF]

Nucleic Acids Research, 2019
Abstract The CCR4–NOT complex plays an important role in the translational repression and deadenylation of mRNAs. However, little is known about the specific roles of interacting factors. We demonstrate that the DEAD-box helicases eIF4A2 and DDX6 interact directly with the MA3 and MIF domains of CNOT1 and compete for binding. Furthermore,
Hedda A Meijer, Tobias Schmidt, Sarah L Gillen, Claudia Langlais, Rebekah Jukes-Jones, Cornelia H de Moor, Kelvin Cain, Ania Wilczynska, Martin Bushell   +8 more
openaire   +3 more sources

The Legionella pneumophila effector PieF modulates mRNA stability through association with eukaryotic CCR4−NOT

mSphere
The eukaryotic CCR4−NOT deadenylase complex is a highly conserved regulator of mRNA metabolism that influences the expression of the complete transcriptome, representing a prime target for a generalist bacterial pathogen.
Harley O'Connor Mount, Malene L. Urbanus, Francesco Zangari, Anne-Claude Gingras, Alexander W. Ensminger   +4 more
doaj   +1 more source

The CAF1-NOT complex of trypanosomes

Frontiers in Genetics, 2014
In African trypanosomes, there is no control of transcription initiation by RNA polymerase II at the level of individual protein-coding genes. Transcription is polycistronic, and individual mRNAs are excised by trans splicing and polyadenylation.
Esteban eErben, Chaitali eChakraborty, Christine eClayton   +2 more
doaj   +1 more source

The ApaH-like phosphatase TbALPH1 is the major mRNA decapping enzyme of trypanosomes. [PDF]

PLoS Pathogens, 2017
5'-3' decay is the major mRNA decay pathway in many eukaryotes, including trypanosomes. After deadenylation, mRNAs are decapped by the nudix hydrolase DCP2 of the decapping complex and finally degraded by the 5'-3' exoribonuclease. Uniquely, trypanosomes
Susanne Kramer
doaj   +1 more source

BTG/TOB factors impact deadenylases. [PDF]

, 2009
BTG/TOB factors are a family of antiproliferative proteins whose expression is altered in numerous cancers. They have been implicated in cell differentiation, development and apoptosis.
Chen, Chyi-Ying A, Mauxion, Fabienne, Shyu, Ann-Bin, Séraphin, Bertrand   +3 more
core   +1 more source

State‐of‐the‐Art Strategies for Circular RNA in Cancers: Opportunity and Challenge

MedComm, Volume 7, Issue 2, February 2026.
Overview of circular RNA in tumors. ABSTRACT Circular RNAs (circRNAs) are characterized by their covalently closed structure, remarkable stability, and precise spatiotemporal regulation, evolving from once‐overlooked transcriptional byproducts to pivotal molecular regulators.
Zehao Ding, Zai Luo, Liao Zhang, Shaopeng Zhang, Renchao Zhang, Zhengjun Qiu, Chen Huang   +6 more
wiley   +1 more source

Evidence Providing New Insights into TOB-Promoted Deadenylation and Supporting a Link between TOB's Deadenylation-Enhancing and Antiproliferative Activities [PDF]

Molecular and Cellular Biology, 2012
The mammalian TOB1 and TOB2 proteins have emerged as key players in repressing cell proliferation. Accumulating evidence indicates that TOBs regulate mRNA deadenylation. A recruitment model was proposed in which TOBs promote deadenylation by recruiting CAF1-CCR4 deadenylase complex to the 3' end of mRNAs by simultaneously binding CAF1 and PABP. However,
Nader, Ezzeddine, Chyi-Ying A, Chen, Ann-Bin, Shyu   +2 more
openaire   +2 more sources

The roles of the exoribonucleases DIS3L2 and XRN1 in disease [PDF]

, 2016
RNA degradation is a vital post-transcriptional process which ensures that transcripts are maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved exoribonucleases which are critical for the degradation of cytoplasmic RNAs ...
Jones, Christopher I, Newbury, Sarah F, Pashler, Amy L, Towler, Ben   +3 more
core   +1 more source