Results 111 to 120 of about 9,376 (189)

Ago-Tnrc6 Triggers Microrna-Mediated Decay By Promoting Two Deadenylation Steps

, 2009
MicroRNAs (miRNAs) silence the expression of their mRNA targets mainly by promoting mRNA decay. The mechanism, kinetics and participating enzymes for miRNA-mediated decay in mammalian cells remain largely unclear.
Shyu, Ann-Bin, Chen, Chyi-Ying A, Ann-Bin Shyu, Zheng, Dinghai, Zhenfang Xia, Xia, Zhenfang, Dinghai Zheng, Chyi-Ying A Chen   +7 more
core   +1 more source

Oskar allows nanos mRNA translation in Drosophila embryos by preventing its deadenylation by Smaug/CCR4.

, 2006
Anteroposterior patterning of the Drosophilaembryo depends on a gradient of Nanos protein arising from the posterior pole. This gradient results from both nanos mRNA translational repression in the bulk of the embryo and translational activation of nanos
Busseau, I., Zaessinger, S., Simonelig, M.   +2 more
core   +1 more source

Functions of Deadenylation Factors In Mrna Decay and Mrna Processing Body Formation [PDF]

, 1980
Most newly synthesized messenger RNAs possess a 5’ cap and a 3’ poly(A) tail. The process of poly(A) tail shortening, also termed deadenylation, is important for post-transcriptional gene regulation, because deadenylation not only leads to mRNA ...
Zheng, Dinghai
core   +1 more source

Mechanisms governing poly(A)-tail-length specificity of the human PAN2-PAN3 deadenylase complex

Cell Reports
Summary: The lifespan of most eukaryotic mRNAs is modulated by the gradual shortening of the poly(A) tail and removal of the associated poly(A)-binding protein.
Jana C. Albrecht, Timo Reitinger, Jérôme Basquin, Steffen Schüssler, Margot Riggi, Ingmar B. Schäfer, Elena Conti   +6 more
doaj   +1 more source

MARTRE family proteins negatively regulate CCR4-NOT activity to protect poly(A) tail length and promote translation of maternal mRNA

Nature Communications
The mammalian early embryo development requires translation of maternal mRNA inherited from the oocyte. While poly(A) tail length influences mRNA translation efficiency during the oocyte-to-embryo transition (OET), molecular mechanisms regulating ...
Jing Yang, Jiachen Bu, Bowen Liu, Yusheng Liu, Zhuqiang Zhang, Ziyi Li, Falong Lu, Bing Zhu, Yingfeng Li   +8 more
doaj   +1 more source

Haploinsufficiency of Cnot3 Aggravates Acid-Induced Acute Lung Injury Likely Through Transcriptional and Post-Transcriptional Upregulation of Pro-Inflammatory Genes

Journal of Inflammation Research
Tomokazu Yamaguchi,1,2,* Ryo Ozawa,2,3,* Takafumi Minato,2 Midori Hoshizaki,4 Yutaro Kammura,1,5 Kazuma Okawara,1,6 Yousef A Khalil,1 Masafumi Nakamura,6 Ken Yamaura,5 Masayuki Fukuda,3 Yumiko Imai,4 Keiji Kuba1,2 1Department of Pharmacology ...
Yamaguchi T, Ozawa R, Minato T, Hoshizaki M, Kammura Y, Okawara K, Khalil YA, Nakamura M, Yamaura K, Fukuda M, Imai Y, Kuba K   +11 more
doaj  

Deadenylation and decapping factors cooperatively stimulate biochemical activities of DEAD-box ATPase Dhh1. [PDF]

Nucleic Acids Res
Braun GA, Kumar R, Hinnebusch AG, Gross JD.   +3 more
europepmc   +1 more source

Enhancing mRNA stability and translational potential through tailored modifications at the 3' end. [PDF]

RSC Chem Biol
Perzanowska O, Kowalska J, Jemielity J.
europepmc   +1 more source

Pontocerebellar hypoplasia linked mutations of the deadenylase Target of EGR1 (TOE1) impair thermal stability, ribonuclease activity, and oligomerization. [PDF]

J Biol Chem
Zavala L, Sobien M, Hayne CK.
europepmc   +1 more source

Selective decay of interferon mRNAs controls antiviral immunity and innate memory. [PDF]

Mol Cell
Braun RM, Ferretti MB, Lee JS, Miller J, Castellana L, Acuña J, Whig K, Dohnalová L, Descamps HC, Huber AS, Muramatsu H, Hewins P, Li Y, Bhutda S, Etwebi Z, Dittmar M, Cook T, Schultz DC, Blackshear PJ, Jurado KA, Thaiss CA, Pardi N, Lynch KW, Cherry S.   +23 more
europepmc   +1 more source