Results 111 to 120 of about 14,275 (206)

From the Understanding of Maternal Molecules and Mechanisms to Predicting Embryonic Development

Reproductive Medicine and Biology, Volume 25, Issue 1, January/December 2026.
ABSTRACT Background Embryo quality is a critical determinant of successful outcomes in assisted reproductive technology (ART). Various molecular and cellular mechanisms in oocytes influence embryo quality, and their understanding can lead to the establishment of selection criteria for enhancing implantation rates. Methods This review summarizes current
Yubao Wei, Akihiro Inoue, Kei Miyamoto
wiley   +1 more source

Critical role of deadenylation in regulating poly(A) rhythms and circadian gene expression.

PLoS Computational Biology, 2020
The mammalian circadian clock is deeply rooted in rhythmic regulation of gene expression. Rhythmic transcriptional control mediated by the circadian transcription factors is thought to be the main driver of mammalian circadian gene expression.
Xiangyu Yao, Shihoko Kojima, Jing Chen
doaj   +1 more source

T4 RNA Ligase 2 truncated active site mutants: improved tools for RNA analysis [PDF]

, 2011
Background T4 RNA ligases 1 and 2 are useful tools for RNA analysis. Their use upstream of RNA analyses such as high-throughput RNA sequencing and microarrays has recently increased their importance.
Sebastien Viollet, Ryan T Fuchs, Daniela B Munafo, Fanglei Zhuang, Gregory B Robb   +4 more
core   +1 more source

The Dual Role of the 16mer Motif Within the 3′ Untranslated Region of the Variant Surface Glycoprotein of Trypanosoma brucei

Molecular Microbiology, Volume 125, Issue 1, Page 67-79, January 2026.
A fully conserved 16mer motif is required in the silent VSG to trigger efficient silencing of the expression site (ES)‐resident VSG and a successful exchange of the VSG coat. ABSTRACT The variant surface glycoprotein (VSG) of African trypanosomes is essential for the survival of bloodstream form parasites.
Majeed Bakari‐Soale, Christopher Batram, Henriette Zimmermann, Nicola G. Jones, Markus Engstler   +4 more
wiley   +1 more source

Maturation of selected human mitochondrial tRNAs requires deadenylation

eLife, 2017
Human mitochondria contain a genome (mtDNA) that encodes essential subunits of the oxidative phosphorylation system. Expression of mtDNA entails multi-step maturation of precursor RNA. In other systems, the RNA life cycle involves surveillance mechanisms, however, the details of RNA quality control have not been extensively characterised in human ...
Sarah F Pearce, Joanna Rorbach, Lindsey Van Haute, Aaron R D’Souza, Pedro Rebelo-Guiomar, Christopher A Powell, Ian Brierley, Andrew E Firth, Michal Minczuk   +8 more
openaire   +4 more sources

The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression

Nature Communications, 2020
The CCR4-NOT complex catalyzes mRNA deadenylation and hence regulates protein translation. Here the authors show that CNOT3 regulation of this complex is needed for positive selection of thymocytes via a mechanism involving inhibition of pro-apoptotic ...
Taku Ito-Kureha, Takahisa Miyao, Saori Nishijima, Toru Suzuki, Shin-ichi Koizumi, Alejandro Villar-Briones, Akinori Takahashi, Nobuko Akiyama, Masahiro Morita, Isao Naguro, Hiroki Ishikawa, Hidenori Ichijo, Taishin Akiyama, Tadashi Yamamoto   +13 more
doaj   +1 more source

The roles of the exoribonucleases DIS3L2 and XRN1 in disease [PDF]

, 2016
RNA degradation is a vital post-transcriptional process which ensures that transcripts are maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved exoribonucleases which are critical for the degradation of cytoplasmic RNAs ...
Jones, Christopher I, Newbury, Sarah F, Pashler, Amy L, Towler, Ben   +3 more
core   +1 more source

Translational control in plants: from basic mechanisms to environmental and developmental responses

The Plant Journal, Volume 125, Issue 1, January 2026.
SUMMARY Protein synthesis is an essential process for all living organisms and is tightly regulated to ensure the proper production of proteins needed for growth, development, and stress responses. As sessile organisms, plants have evolved distinct mechanisms to regulate translation, allowing them to adapt to their environment.
Jade Lyons, Catharina Merchante, Anna N. Stepanova, Jose M. Alonso   +3 more
wiley   +1 more source

The enzyme activities of Caf1 and Ccr4 are both required for deadenylation by the human Ccr4-Not nuclease module [PDF]

, 2015
In eukaryotic cells, the shortening and removal of the poly(A) tail (deadenylation) of cytoplasmic mRNA is a key event in regulated mRNA degradation. A major enzyme involved in deadenylation is the Ccr4-Not deadenylase complex, which can be recruited to ...
Aslam, Basquin, Bhandari, Bianchin, Blessing Airhihen, Braun, Chang, Chekulaeva, Chen, Chen, Chen, Clark, Collart, Daugeron, Doidge, Dupressoir, Ezzeddine, Ezzeddine, Fabian, Fabian, Funakoshi, G. Sebastiaan Winkler, Garneau, Goldstrohm, Horiuchi, Maryati, Maryati Maryati, Mathys, Mauxion, Mauxion, Mittal, Morozov, Parker, Petit, Rouault, Sandler, Subtelny, Suzuki, Takahashi, Tucker, Tucker, Viswanathan, Wahle, Wang, Winkler, Xu, Yamashita, Yang   +47 more
core   +4 more sources

A SspI PCR-RFLP detecting a silent allele at the goat CSN2 locus [PDF]

, 2005
The comparison between the cDNA sequence obtained and the published sequences of the goat CSN2 alleles showed a new single nucleotide polymorphism (SNP) (transition C-T) at the 180th nucleotide of the ninth exon.
COSENZA, GIANFRANCO, DI BERARDINO D., GALLO, DANIELA, PAUCIULLO A., RAMUNNO L.   +4 more
core   +1 more source