Results 91 to 100 of about 9,376 (189)

RNA-binding proteins distinguish between similar sequence motifs to promote targeted deadenylation by Ccr4-Not

eLife, 2019
The Ccr4-Not complex removes mRNA poly(A) tails to regulate eukaryotic mRNA stability and translation. RNA-binding proteins contribute to specificity by interacting with both Ccr4-Not and target mRNAs, but this is not fully understood.
Michael W Webster, James AW Stowell, Lori A Passmore   +2 more
doaj   +1 more source

Critical role of deadenylation in regulating poly(A) rhythms and circadian gene expression.

PLoS Computational Biology, 2020
The mammalian circadian clock is deeply rooted in rhythmic regulation of gene expression. Rhythmic transcriptional control mediated by the circadian transcription factors is thought to be the main driver of mammalian circadian gene expression.
Xiangyu Yao, Shihoko Kojima, Jing Chen
doaj   +1 more source

Co‐translational protein targeting to mitochondria in the context of co‐translational protein maturation

Protein Science, Volume 35, Issue 7, July 2026.
Abstract Mitochondria import the majority of their proteins from the cytosol, creating a fundamental challenge: precursor proteins must be synthesized, maintained in an import‐competent state, and delivered to mitochondrial translocases without premature folding or aggregation. While mitochondrial protein import has been considered a post‐translational
Nikita A. Kvasov, Yury S. Bykov
wiley   +1 more source

Deadenylation Is Prerequisite For P-Body Formation and Mrna Decay In Mammalian Cells [PDF]

, 2008
Deadenylation is the major step triggering mammalian mRNA decay. One consequence of deadenylation is the formation of nontranslatable messenger RNA (mRNA) protein complexes (messenger ribonucleoproteins [mRNPs]). Nontranslatable mRNPs may accumulate in P-
Zhu, Wenmiao, Shyu, Ann-Bin, Xiangwei He, Chen, Chyi-Ying A, Ann-Bin Shyu, Zheng, Dinghai, Ezzeddine, Nader, He, Xiangwei, Dinghai Zheng, Wenmiao Zhu, Chyi-Ying A. Chen, Nader Ezzeddine   +11 more
core   +1 more source

Noncoding RNAs and the Architecture of Gene Regulation: Focus on Long and Small Regulatory RNAs

WIREs RNA, Volume 17, Issue 4, July/August 2026.
NcRNAs play fundamental roles in many facets of cellular homeostasis, systemic physiology and disease outcomes. Historical and current advancements have led to a deeper understanding of ncRNAs' roles, utilizing their diverse and tissue‐specific functions to drive the development of innovative therapeutic tools.
Samuel Z. Desind, Samira K. Bell, Carol S. Lutz   +2 more
wiley   +1 more source

The CCR4–NOT deadenylase complex safeguards thymic positive selection by down-regulating aberrant pro-apoptotic gene expression

Nature Communications, 2020
The CCR4-NOT complex catalyzes mRNA deadenylation and hence regulates protein translation. Here the authors show that CNOT3 regulation of this complex is needed for positive selection of thymocytes via a mechanism involving inhibition of pro-apoptotic ...
Taku Ito-Kureha, Takahisa Miyao, Saori Nishijima, Toru Suzuki, Shin-ichi Koizumi, Alejandro Villar-Briones, Akinori Takahashi, Nobuko Akiyama, Masahiro Morita, Isao Naguro, Hiroki Ishikawa, Hidenori Ichijo, Taishin Akiyama, Tadashi Yamamoto   +13 more
doaj   +1 more source

Stapled Peptides as Inhibitors of mRNA Deadenylation

Angewandte Chemie International Edition
AbstractTherapeutic intervention targeting mRNA typically aims at reducing the levels of disease‐causing sequences. Achieving the opposite effect of blocking the destruction of beneficial mRNA remains underexplored. The degradation of mRNA starts with the removal of poly(A) tails, reducing their stability and translational activity, which is mainly ...
Sunit Pal, Ilja Gordijenko, Stefan Schmeing, Somarghya Biswas, Yasemin Akbulut, Raphael Gasper, Peter 't Hart   +6 more
openaire   +3 more sources

Analysis of mRNA deadenylation by multi-protein complexes

Methods, 2017
Poly(A) tails are found at the 3' end of almost every eukaryotic mRNA and are important for the stability of mRNAs and their translation into proteins. Thus, removal of the poly(A) tail, a process called deadenylation, is critical for regulation of gene expression. Most deadenylation enzymes are components of large multi-protein complexes.
Webster, Michael W., Stowell, James A.W., Tang, Terence T.L., Passmore, Lori A.   +3 more
openaire   +3 more sources

Recycling of Uridylated mRNAs in Starfish Embryos

Biomolecules
In eukaryotes, mRNAs with long poly(A) tails are translationally active, but deadenylation and uridylation of these tails generally cause mRNA degradation. However, the fate of uridylated mRNAs that are not degraded quickly remains obscure.
Haruka Yamazaki, Megumi Furuichi, Mikoto Katagiri, Rei Kajitani, Takehiko Itoh, Kazuyoshi Chiba   +5 more
doaj   +1 more source

Estrogen receptor alpha (ERα) regulates PARN-mediated nuclear deadenylation and gene expression in breast cancer cells

RNA Biology
The estrogen signalling pathway is highly dynamic and primarily mediated by estrogen receptors (ERs) that transcriptionally regulate the expression of target genes.
Sophia Varriano, Amy Yu, Yu Qing Xu, Devorah M. Natelson, Anthony Ramadei, Frida E. Kleiman   +5 more
doaj   +1 more source